Drug Discovery and Pre-Clinical Development
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Questions and Answers

What is a drug?

Any substance, other than food, used in the prevention, diagnosis, or treatment of a disease.

What is drug discovery?

The process through which new chemical entities are discovered as potential therapeutic agents.

What is drug development?

The process of bringing a lead compound to the market by testing safety and efficacy in humans with a suitable formulation.

What makes a good drug? (Select all that apply)

<p>Targets an unmet medical need</p> Signup and view all the answers

Drug discovery and development is a low-risk undertaking.

<p>False</p> Signup and view all the answers

A drug should not cause any serious adverse side effects or long-term ______.

<p>toxicity</p> Signup and view all the answers

Study Notes

Drug Discovery and Development Overview

  • A drug is any substance, excluding food, used for disease prevention, diagnosis, or treatment.
  • Drug discovery involves finding new chemical entities that can act as therapeutic agents.
  • Drug development is the process of bringing a discovered compound to market by evaluating its safety and efficacy in humans.

Characteristics of a Good Drug

  • Targets an unmet medical need effectively.
  • Capable of curing diseases or alleviating symptoms.
  • Stops disease progression promptly without complex dosing.
  • Safe for use, with minimal serious side effects or long-term toxicity.
  • Does not interfere with the pharmacology of other medications.
  • Economically viable for manufacturing and distribution.

Drug Discovery and Development Challenges

  • Characterized by high risk and high attrition rates during development.
  • The process is expensive with low success rates.

Pre-Clinical Development

  • Involves extensive testing of potential drugs before human clinical trials.
  • Evaluates safety, efficacy, and formulation of lead compounds derived from drug discovery.

Project Milestones and Governance at Novartis

  • Milestones are essential checkpoints during drug development to assess progress and make decisions.
  • Governance board oversees project milestones, ensuring alignment with company strategies and regulatory compliance.

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Description

Explore the essential concepts of drug discovery and pre-clinical development presented by Jayant Sancheti from PK Sciences. This educational quiz focuses on the key stages and methodologies used in the pharmaceutical industry, enhancing your understanding of the field.

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