8 Questions
Isolation and purification is the final step in the drug discovery process
True
Choosing a disease is the first step in the drug discovery process
True
Structure determination is part of the drug discovery process
True
What is reverse pharmacology?
Reverse pharmacology is the process of using high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease-modifying.
What are the traditional sources of new candidate medications in drug discovery?
Traditional sources of new candidate medications in drug discovery include identifying the active ingredient from traditional remedies or serendipitous discovery.
What is the historical method of drug discovery?
Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery.
What is the role of high throughput screening in modern drug discovery?
In modern drug discovery, high throughput screening is used to screen large compounds libraries against isolated biological targets to identify substances with a desirable therapeutic effect.
How has the sequencing of the human genome impacted drug discovery?
The sequencing of the human genome has allowed rapid cloning and synthesis of large quantities of purified proteins, enabling the common practice of using high throughput screening of large compounds libraries against isolated biological targets.
Study Notes
Drug Discovery Process
- Isolation and purification is the final step in the process
- Choosing a disease is the initial step in the process
- Structure determination is a part of the process
Reverse Pharmacology
- Reverse pharmacology is a method of drug discovery
Traditional Sources of Medications
- Traditional sources of new candidate medications include natural products, such as plants, animals, and microorganisms, and synthesis of new compounds based on existing medications
Historical Method of Drug Discovery
- The historical method of drug discovery is based on serendipity, where a compound is tested for a particular disease, and if it shows a positive effect, it is further developed and optimized
High Throughput Screening
- High throughput screening is a method used in modern drug discovery to rapidly test a large number of compounds for their potential as medications
Impact of Human Genome Sequencing
- The sequencing of the human genome has impacted drug discovery by providing a better understanding of the genetic basis of diseases, allowing for the development of more targeted and effective medications
Test your knowledge of drug discovery and development with this quiz. Explore the steps involved in identifying a drug target, isolating and purifying compounds, and determining their structure. Learn about bioassays, lead compounds, and the role of herbal medicine in the process.
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