Drug Development: Formulation & Biopharmaceutical Considerations Quiz

Dissolution is the loss of cohesion of a solid within a liquid leading to division in the molecular or ionic state, where the solid-solvent attraction forces are greater than the solid-solid cohesion forces.

Generally, a drug substance must be in solution in order to be absorbed by the body.

Solubility is the maximum concentration of a substance that may be completely dissolved in a given solvent at a given temperature and pressure, representing a stationary equilibrium.

Miscibility is the term used to describe the affinity between liquids in the context of solubility.

A substance that requires 10,000 parts of solvent for 1 part of solute is classified as 'very soluble' according to the USP terms of solubility.

The concentration of a saturated solution of glucose at 25°C is 909 g/L.

The partition coefficient, which measures the distribution of a substance in a lipophilic/hydrophilic system, influences the ability of an API to diffuse across biological membranes (composed of proteins and lipids) that act as lipophilic barriers.

An unsaturated solution contains less solute than the maximum amount that can be dissolved in the solvent at a given temperature and pressure, while a saturated solution contains the maximum amount of solute that can be dissolved under those conditions.

The three key steps involved in the absorption of a drug substance by the body are dissolution, diffusion, and absorption.

The active ingredient being in solution is significant because it allows for dissolution, diffusion, and absorption, which are necessary steps for the drug substance to have a pharmacological response in the body.