Drug Development: Formulation & Biopharmaceutical Considerations Quiz

Dissolution is the loss of cohesion of a solid within a liquid leading to division in the molecular or ionic state, where the solid-solvent attraction forces are greater than the solid-solid cohesion forces.

Generally, a drug substance must be in solution in order to be absorbed by the body.

Solubility is the maximum concentration of a substance that may be completely dissolved in a given solvent at a given temperature and pressure, representing a stationary equilibrium.

<p>Miscibility is the term used to describe the affinity between liquids in the context of solubility.</p> Signup and view all the answers

<p>A substance that requires 10,000 parts of solvent for 1 part of solute is classified as 'very soluble' according to the USP terms of solubility.</p> Signup and view all the answers

<p>The concentration of a saturated solution of glucose at 25°C is 909 g/L.</p> Signup and view all the answers

<p>The partition coefficient, which measures the distribution of a substance in a lipophilic/hydrophilic system, influences the ability of an API to diffuse across biological membranes (composed of proteins and lipids) that act as lipophilic barriers.</p> Signup and view all the answers

<p>An unsaturated solution contains less solute than the maximum amount that can be dissolved in the solvent at a given temperature and pressure, while a saturated solution contains the maximum amount of solute that can be dissolved under those conditions.</p> Signup and view all the answers

<p>The three key steps involved in the absorption of a drug substance by the body are dissolution, diffusion, and absorption.</p> Signup and view all the answers

<p>The active ingredient being in solution is significant because it allows for dissolution, diffusion, and absorption, which are necessary steps for the drug substance to have a pharmacological response in the body.</p> Signup and view all the answers