10 Questions
What are the main objectives of Novel Drug Delivery Systems (DDSs)?
Increasing solubility and efficacy, minimizing toxic effects, optimizing duration of drug effect
How do Targeted Drug Delivery Systems differ from conventional drug delivery systems?
They aim to accumulate therapeutic agents at the target site instead of nontarget sites.
What is Passive Targeting in drug delivery systems and how does it work?
It involves drug delivery vehicles accumulating at the target site due to leaky vasculature around the diseased site as a result of the enhanced permeability and retention (EPR) effect.
What is the key factor for the success of Passive Targeting in drug delivery?
Particle size and circulation time
How does Active Targeting in drug delivery systems differ from Passive Targeting?
Active targeting involves specific ligands or antibodies to target drug delivery vehicles to particular receptors or markers on cells, while passive targeting relies on the EPR effect.
What is the role of Physical Targeting in drug delivery systems?
Physical targeting uses physical stimuli like temperature, ultrasound, or magnetic fields to trigger drug release at the target site.
How does Targeted Drug Delivery help minimize the systemic concentration of therapeutic agents?
By delivering therapeutic agents primarily to the target site, reducing exposure to nontarget sites.
What are some common strategies used in Targeted Drug Delivery Systems?
Active targeting, passive targeting, physical targeting, etc.
How do Targeted Drug Delivery Systems improve drug efficacy and reduce side effects?
By delivering therapeutic agents directly to the target site, increasing effectiveness and minimizing exposure to healthy tissues.
What is the significance of particle size in Passive Targeting?
Particle size affects the accumulation of drug delivery vehicles at the target site.
Test your knowledge on the challenges faced in drug delivery, including poor bioavailability, non-specific distribution, and difficulties reaching the desired site of action in the body. Explore the factors that impact drug effectiveness and safety.
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