Drug Delivery Challenges Quiz
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Questions and Answers

What are the main objectives of Novel Drug Delivery Systems (DDSs)?

Increasing solubility and efficacy, minimizing toxic effects, optimizing duration of drug effect

How do Targeted Drug Delivery Systems differ from conventional drug delivery systems?

They aim to accumulate therapeutic agents at the target site instead of nontarget sites.

What is Passive Targeting in drug delivery systems and how does it work?

It involves drug delivery vehicles accumulating at the target site due to leaky vasculature around the diseased site as a result of the enhanced permeability and retention (EPR) effect.

What is the key factor for the success of Passive Targeting in drug delivery?

<p>Particle size and circulation time</p> Signup and view all the answers

How does Active Targeting in drug delivery systems differ from Passive Targeting?

<p>Active targeting involves specific ligands or antibodies to target drug delivery vehicles to particular receptors or markers on cells, while passive targeting relies on the EPR effect.</p> Signup and view all the answers

What is the role of Physical Targeting in drug delivery systems?

<p>Physical targeting uses physical stimuli like temperature, ultrasound, or magnetic fields to trigger drug release at the target site.</p> Signup and view all the answers

How does Targeted Drug Delivery help minimize the systemic concentration of therapeutic agents?

<p>By delivering therapeutic agents primarily to the target site, reducing exposure to nontarget sites.</p> Signup and view all the answers

What are some common strategies used in Targeted Drug Delivery Systems?

<p>Active targeting, passive targeting, physical targeting, etc.</p> Signup and view all the answers

How do Targeted Drug Delivery Systems improve drug efficacy and reduce side effects?

<p>By delivering therapeutic agents directly to the target site, increasing effectiveness and minimizing exposure to healthy tissues.</p> Signup and view all the answers

What is the significance of particle size in Passive Targeting?

<p>Particle size affects the accumulation of drug delivery vehicles at the target site.</p> Signup and view all the answers

Study Notes

Limitations of Conventional Drug Delivery Systems

  • Delivering drugs to the desired site of action in the body remains a major challenge
  • Poor bioavailability is a limitation due to low solubility, stability, or permeability in the gastrointestinal tract
  • Non-specific distribution of drugs throughout the body can cause unwanted side effects in healthy organs and tissues
  • Some drugs may not reach the target site at a sufficient concentration to exert their therapeutic effect, especially in poorly vascularized or protected areas
  • Lack of control over the timing, duration, and intensity of drug release can result in suboptimal drug exposure
  • Patient compliance can be affected by invasive, painful, or uncomfortable conventional delivery methods

Novel Drug Delivery Systems (DDSs)

  • Controlled release DDSs are required to maintain constant plasma drug levels within the therapeutic window
  • Targeting the drug to the site of intended pharmacological activity is crucial to prevent unwanted effects on other organs
  • Particles should be able to penetrate fenestrations in tumor vessels (200-800nm) and have sufficient circulation time to accumulate

Targeted Delivery

  • Most common types: active, passive, and physical targeting
  • Passive targeting uses the enhanced permeability and retention (EPR) effect to accumulate high-molecular weight drugs in tissues with increased vascular permeability
  • Physical targeting methods include:
    • Using devices (e.g., catheters) to position drugs at the target site
    • Direct accessibility to most organs requires open surgical procedures or guiding devices
    • Using magnetic fields to attract drug delivery vehicles with magnetic properties to the target

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Description

Test your knowledge on the challenges faced in drug delivery, including poor bioavailability, non-specific distribution, and difficulties reaching the desired site of action in the body. Explore the factors that impact drug effectiveness and safety.

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