Drug Classification Quiz: Antihistamines and their Effects
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Questions and Answers

What is the mechanism of action of histamine on H1 receptors?

  • Bronchodilatation (correct)
  • Vasodilation
  • Vasoconstriction
  • Increased cardiac contractility
  • Which receptor subtype does epinephrine act on to induce vasoconstriction in anaphylaxis?

  • Beta2-adrenoceptors
  • Histamine receptors
  • Alpha-adrenoceptors (correct)
  • Beta1-adrenoceptors
  • Why is epinephrine considered life-saving in the treatment of anaphylaxis?

  • It stimulates vasoconstriction (correct)
  • It induces bronchospasm
  • It inhibits histamine release
  • It increases vascular leakage
  • How are allergic diseases diagnosed according to the text?

    <p>Skin prick testing</p> Signup and view all the answers

    Which drug is administered to inhibit vasodilation, vascular leakage, and bronchospasm during anaphylaxis?

    <p>Diphenhydramine</p> Signup and view all the answers

    What is the primary function of beta2 adrenoceptor agonists during anaphylaxis?

    <p>Bronchodilation</p> Signup and view all the answers

    Which receptor type is responsible for causing bronchoconstriction in hypersensitivity type I reactions?

    <p>H1 receptors</p> Signup and view all the answers

    In allergic reactions, which molecule stored in mast cell granules acts on specific histamine receptors?

    <p>Histamine</p> Signup and view all the answers

    Anaphylactic reactions are mediated by which type of antibodies?

    <p>IgE antibodies</p> Signup and view all the answers

    What is the central role of histamine in mild allergic reactions?

    <p>Increasing capillary permeability and vasodilatation</p> Signup and view all the answers

    Which symptom is NOT commonly associated with anaphylaxis?

    <p>Myocardial infarction</p> Signup and view all the answers

    What happens when allergen cross-links IgE on mast cells during hypersensitivity type I reactions?

    <p>Mediator release from mast cells is triggered</p> Signup and view all the answers

    Which of the following is a characteristic of 'inverse agonists'?

    <p>They induce a pharmacological response opposite to that of the agonist.</p> Signup and view all the answers

    Which type of anti-histamines are known for exhibiting additional anti-inflammatory effects?

    <p>Second generation anti-histamines</p> Signup and view all the answers

    What is a common adverse effect associated with topical calcineurin inhibitors like Tacrolimus?

    <p>Burning sensation in the skin</p> Signup and view all the answers

    Which of the following statements about Terfenadine is true?

    <p>It can be subject to a clinically significant drug-drug interaction.</p> Signup and view all the answers

    Which of the following anti-histamines is NOT a second-generation type?

    <p>Diphenhydramine</p> Signup and view all the answers

    What makes Loratadine distinct from other anti-histamines in terms of crossing the blood-brain barrier?

    <p>It is lipophobic and hence does not cross the blood-brain barrier.</p> Signup and view all the answers

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