Podcast
Questions and Answers
What is the mechanism of action of histamine on H1 receptors?
What is the mechanism of action of histamine on H1 receptors?
- Bronchodilatation (correct)
- Vasodilation
- Vasoconstriction
- Increased cardiac contractility
Which receptor subtype does epinephrine act on to induce vasoconstriction in anaphylaxis?
Which receptor subtype does epinephrine act on to induce vasoconstriction in anaphylaxis?
- Beta2-adrenoceptors
- Histamine receptors
- Alpha-adrenoceptors (correct)
- Beta1-adrenoceptors
Why is epinephrine considered life-saving in the treatment of anaphylaxis?
Why is epinephrine considered life-saving in the treatment of anaphylaxis?
- It stimulates vasoconstriction (correct)
- It induces bronchospasm
- It inhibits histamine release
- It increases vascular leakage
How are allergic diseases diagnosed according to the text?
How are allergic diseases diagnosed according to the text?
Which drug is administered to inhibit vasodilation, vascular leakage, and bronchospasm during anaphylaxis?
Which drug is administered to inhibit vasodilation, vascular leakage, and bronchospasm during anaphylaxis?
What is the primary function of beta2 adrenoceptor agonists during anaphylaxis?
What is the primary function of beta2 adrenoceptor agonists during anaphylaxis?
Which receptor type is responsible for causing bronchoconstriction in hypersensitivity type I reactions?
Which receptor type is responsible for causing bronchoconstriction in hypersensitivity type I reactions?
In allergic reactions, which molecule stored in mast cell granules acts on specific histamine receptors?
In allergic reactions, which molecule stored in mast cell granules acts on specific histamine receptors?
Anaphylactic reactions are mediated by which type of antibodies?
Anaphylactic reactions are mediated by which type of antibodies?
What is the central role of histamine in mild allergic reactions?
What is the central role of histamine in mild allergic reactions?
Which symptom is NOT commonly associated with anaphylaxis?
Which symptom is NOT commonly associated with anaphylaxis?
What happens when allergen cross-links IgE on mast cells during hypersensitivity type I reactions?
What happens when allergen cross-links IgE on mast cells during hypersensitivity type I reactions?
Which of the following is a characteristic of 'inverse agonists'?
Which of the following is a characteristic of 'inverse agonists'?
Which type of anti-histamines are known for exhibiting additional anti-inflammatory effects?
Which type of anti-histamines are known for exhibiting additional anti-inflammatory effects?
What is a common adverse effect associated with topical calcineurin inhibitors like Tacrolimus?
What is a common adverse effect associated with topical calcineurin inhibitors like Tacrolimus?
Which of the following statements about Terfenadine is true?
Which of the following statements about Terfenadine is true?
Which of the following anti-histamines is NOT a second-generation type?
Which of the following anti-histamines is NOT a second-generation type?
What makes Loratadine distinct from other anti-histamines in terms of crossing the blood-brain barrier?
What makes Loratadine distinct from other anti-histamines in terms of crossing the blood-brain barrier?
Flashcards
Histamine's effect on H1 receptors
Histamine's effect on H1 receptors
Causes bronchodilation through action on H1 receptors.
Epinephrine in anaphylaxis
Epinephrine in anaphylaxis
Induces vasoconstriction via alpha-adrenoceptors during anaphylaxis.
Why Epinephrine is life-saving
Why Epinephrine is life-saving
It stimulates vasoconstriction, which raises blood pressure and improves circulation.
Diagnosing allergic diseases
Diagnosing allergic diseases
Diagnosis involves skin prick testing to identify specific allergens.
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Diphenhydramine use in anaphylaxis
Diphenhydramine use in anaphylaxis
Used to inhibit vasodilation, vascular leakage, and bronchospasm during anaphylaxis.
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Beta2 adrenoceptor agonists
Beta2 adrenoceptor agonists
Promote bronchodilation, opening up the airways for easier breathing.
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H1 receptors in hypersensitivity
H1 receptors in hypersensitivity
H1 receptors cause bronchoconstriction, narrowing the airways.
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Role of histamine
Role of histamine
Histamine, stored in mast cell granules, acts on specific histamine receptors.
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Antibodies in anaphylaxis
Antibodies in anaphylaxis
Anaphylactic reactions are primarily mediated by IgE antibodies.
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Histamine in mild allergic reactions
Histamine in mild allergic reactions
Increases capillary permeability and vasodilatation.
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Not a symptom of anaphylaxis
Not a symptom of anaphylaxis
Myocardial infarction (heart attack)
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Allergen cross-linking IgE
Allergen cross-linking IgE
Triggers mediator release from mast cells, which can cause various allergic symptoms.
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Inverse agonists
Inverse agonists
Induce a pharmacological response opposite to that of the agonist.
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Anti-histamines with anti-inflammatory effects
Anti-histamines with anti-inflammatory effects
Second generation anti-histamines
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Adverse effect of topical calcineurin inhibitors
Adverse effect of topical calcineurin inhibitors
Burning sensation in the skin
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Statement about Terfenadine
Statement about Terfenadine
It can be subject to a clinically significant drug-drug interaction.
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NOT a second-generation anti-histamine
NOT a second-generation anti-histamine
Diphenhydramine
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Loratadine's unique feature
Loratadine's unique feature
It is lipophobic and hence does not cross the blood-brain barrier.
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