18 Questions
What is the mechanism of action of histamine on H1 receptors?
Bronchodilatation
Which receptor subtype does epinephrine act on to induce vasoconstriction in anaphylaxis?
Alpha-adrenoceptors
Why is epinephrine considered life-saving in the treatment of anaphylaxis?
It stimulates vasoconstriction
How are allergic diseases diagnosed according to the text?
Skin prick testing
Which drug is administered to inhibit vasodilation, vascular leakage, and bronchospasm during anaphylaxis?
Diphenhydramine
What is the primary function of beta2 adrenoceptor agonists during anaphylaxis?
Bronchodilation
Which receptor type is responsible for causing bronchoconstriction in hypersensitivity type I reactions?
H1 receptors
In allergic reactions, which molecule stored in mast cell granules acts on specific histamine receptors?
Histamine
Anaphylactic reactions are mediated by which type of antibodies?
IgE antibodies
What is the central role of histamine in mild allergic reactions?
Increasing capillary permeability and vasodilatation
Which symptom is NOT commonly associated with anaphylaxis?
Myocardial infarction
What happens when allergen cross-links IgE on mast cells during hypersensitivity type I reactions?
Mediator release from mast cells is triggered
Which of the following is a characteristic of 'inverse agonists'?
They induce a pharmacological response opposite to that of the agonist.
Which type of anti-histamines are known for exhibiting additional anti-inflammatory effects?
Second generation anti-histamines
What is a common adverse effect associated with topical calcineurin inhibitors like Tacrolimus?
Burning sensation in the skin
Which of the following statements about Terfenadine is true?
It can be subject to a clinically significant drug-drug interaction.
Which of the following anti-histamines is NOT a second-generation type?
Diphenhydramine
What makes Loratadine distinct from other anti-histamines in terms of crossing the blood-brain barrier?
It is lipophobic and hence does not cross the blood-brain barrier.
Test your knowledge on antihistamines, focusing on their classification, effects, and uses. Explore concepts like lipophilic and lipophobic drugs, BBB penetration, adverse effects, and anti-inflammatory properties. Identify different generations of antihistamines and their respective examples.
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