Drug Biotransformation Quiz

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Questions and Answers

Which organ is the most important for biotransformation of drugs?

  • Lungs
  • Gut mucosa
  • Kidney
  • Liver (correct)

What is the primary purpose of biotransformation in the body?

  • To convert drugs into more polar, water-soluble compounds for easier excretion through the kidneys (correct)
  • To decrease excretion through the kidneys
  • To make drugs more lipid-soluble
  • To activate inactive drugs

Which drug is an example of being largely excreted unchanged in the urine?

  • Furosemide (correct)
  • Paracetamol
  • Enrofloxacin
  • Ciprofloxacin

What is the consequence of biotransformation for some drugs?

<p>Inactivation (D)</p> Signup and view all the answers

Where are biotransformation reactions catalyzed by enzymes located?

<p>Both in the liver microsomes and cytoplasm/mitochondria (C)</p> Signup and view all the answers

Flashcards

Main Biotransformation Organ

The liver is the primary organ responsible for the biotransformation of drugs in the body.

Purpose of Biotransformation

Biotransformation converts drugs into more polar, water-soluble compounds, facilitating their excretion via the kidneys.

Drug Excreted Unchanged

An example is Furosemide.

Consequence of Biotransformation

Biotransformation can lead to drug inactivation, reducing its pharmacological effect.

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Location of Biotransformation Enzymes

Biotransformation reactions are catalyzed by enzymes located in both the liver microsomes and cytoplasm/mitochondria.

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