Podcast
Questions and Answers
Which neurotransmitter is identified as the primary inhibitory neurotransmitter in the brain?
Which neurotransmitter is identified as the primary inhibitory neurotransmitter in the brain?
- Acetylcholine
- Serotonin
- GABA (correct)
- Dopamine
What is the primary mechanism of termination of action of a bolus dose of an anesthetic induction agent?
What is the primary mechanism of termination of action of a bolus dose of an anesthetic induction agent?
- Activation of specific receptors
- Metabolism by the liver
- Excretion by the kidneys
- Redistribution to the vessel intermediate group (correct)
What is the definition of efficacy of a drug?
What is the definition of efficacy of a drug?
- The duration of action in the body
- The ability to produce side effects
- The maximal response when all receptor sites are occupied (correct)
- The ability to reach peak plasma concentration quickly
What does volume of distribution represent?
What does volume of distribution represent?
Which section in the pharmacology review focuses on Neuromuscular blockers?
Which section in the pharmacology review focuses on Neuromuscular blockers?
What is the cumulative percentage contribution of 'Inhaled Anesthetics' to the final exam?
What is the cumulative percentage contribution of 'Inhaled Anesthetics' to the final exam?
Which of the following is considered the best measure of renal function?
Which of the following is considered the best measure of renal function?
What is the primary inhibitory neurotransmitter in the brain?
What is the primary inhibitory neurotransmitter in the brain?
Which ion has a higher extracellular concentration and depolarizes the cell when it enters?
Which ion has a higher extracellular concentration and depolarizes the cell when it enters?
Which receptor type is associated with rapid synaptic transmission, synaptic plasticity, and long-term potentiation?
Which receptor type is associated with rapid synaptic transmission, synaptic plasticity, and long-term potentiation?
What are the primary targets of adenosine in the context of anesthesia-related drugs?
What are the primary targets of adenosine in the context of anesthesia-related drugs?
What effect do benzodiazepines have on the GABAA receptor?
What effect do benzodiazepines have on the GABAA receptor?
Which type of ion channels respond to changes in voltage across the cell membrane and play an important role in the transmission of impulses in neurons and skeletal muscle?
Which type of ion channels respond to changes in voltage across the cell membrane and play an important role in the transmission of impulses in neurons and skeletal muscle?
Which ion typically traverses the channel when depolarization occurs in voltage-gated ion channels?
Which ion typically traverses the channel when depolarization occurs in voltage-gated ion channels?
Which receptors are coupled to G protein-regulated inwardly rectifying potassium channels (GIRKs)?
Which receptors are coupled to G protein-regulated inwardly rectifying potassium channels (GIRKs)?
What is the term for the decreased postsynaptic firing following rapid, repetitive firing which is presumably due to exhaustion of neurotransmitters?
What is the term for the decreased postsynaptic firing following rapid, repetitive firing which is presumably due to exhaustion of neurotransmitters?
What is defined by the dose or concentration needed to produce a defined effect, such as ED50 or (EC50) in receptor theory?
What is defined by the dose or concentration needed to produce a defined effect, such as ED50 or (EC50) in receptor theory?
What term describes the existence of spare receptors in the presence of a maximal tissue response in the absence of 100% receptor binding by an agonist?
What term describes the existence of spare receptors in the presence of a maximal tissue response in the absence of 100% receptor binding by an agonist?
Which of the following statements regarding drug absorption is true?
Which of the following statements regarding drug absorption is true?
What is the primary mechanism of termination of action of a bolus dose of an induction agent?
What is the primary mechanism of termination of action of a bolus dose of an induction agent?
Which factor affects the volume of distribution of a drug?
Which factor affects the volume of distribution of a drug?
What is the main function of phase I drug metabolism reactions?
What is the main function of phase I drug metabolism reactions?
Which statement about hepatic clearance is accurate?
Which statement about hepatic clearance is accurate?
How does concentration of plasma proteins affect drug binding and distribution?
How does concentration of plasma proteins affect drug binding and distribution?
What is the most reliable measure of glomerular filtration rate (GFR)?
What is the most reliable measure of glomerular filtration rate (GFR)?
Which process involves the measurement of drug concentration in multiple tissues over time?
Which process involves the measurement of drug concentration in multiple tissues over time?
In pharmacokinetic models, what is assumed to occur only from the central compartment?
In pharmacokinetic models, what is assumed to occur only from the central compartment?
What is the equation for a two compartment model following IV injection of a dose A+B?
What is the equation for a two compartment model following IV injection of a dose A+B?
Which model describes the pharmacokinetics of most anesthetic drugs with assumptions of linear first-order processes and time invariance?
Which model describes the pharmacokinetics of most anesthetic drugs with assumptions of linear first-order processes and time invariance?
What does the context-sensitive half-time refer to?
What does the context-sensitive half-time refer to?
Which drug delivery method is experimental and not available commercially for anesthetic purposes?
Which drug delivery method is experimental and not available commercially for anesthetic purposes?
What is the ratio used to determine the safety of a drug?
What is the ratio used to determine the safety of a drug?
Which factor is identified as the most important determinant of metabolic rate in interpatient variability?
Which factor is identified as the most important determinant of metabolic rate in interpatient variability?
What is the equation for Target Controlled Infusions dependent on?
What is the equation for Target Controlled Infusions dependent on?
Which section in the pharmacology review focuses on the net effect of combining two drugs, which may be additive, synergistic, or antagonistic?
Which section in the pharmacology review focuses on the net effect of combining two drugs, which may be additive, synergistic, or antagonistic?
What does MACAWAKE represent?
What does MACAWAKE represent?
What does the Context-Sensitive Decrement-Time allow the substitution for?
What does the Context-Sensitive Decrement-Time allow the substitution for?
Which factor can cause variation in plasma concentrations using the same dosing regimen up to 2-fold?
Which factor can cause variation in plasma concentrations using the same dosing regimen up to 2-fold?
What are probability isoboles typically at?
What are probability isoboles typically at?
