Podcast
Questions and Answers
Which medication is known for its selective inhibition of cyclooxygenase 2 and is associated with fewer gastrointestinal side effects compared to nonselective agents?
Which medication is known for its selective inhibition of cyclooxygenase 2 and is associated with fewer gastrointestinal side effects compared to nonselective agents?
What is the most significant adverse effect associated with the use of infliximab in patients with inflammatory bowel disease?
What is the most significant adverse effect associated with the use of infliximab in patients with inflammatory bowel disease?
Which medication can cause extrapyramidal manifestations such as tardive dyskinesia and should be managed with Benadryl?
Which medication can cause extrapyramidal manifestations such as tardive dyskinesia and should be managed with Benadryl?
Which medication is a derivative of prostaglandin E1 and is used to prevent peptic ulcer disease in patients on chronic NSAIDs?
Which medication is a derivative of prostaglandin E1 and is used to prevent peptic ulcer disease in patients on chronic NSAIDs?
Signup and view all the answers
What is the most common side effect associated with gadolinium contrast?
What is the most common side effect associated with gadolinium contrast?
Signup and view all the answers
Which medication is known to cause metabolic alkalosis, hypokalemia, and ototoxicity as side effects due to over-diuresis?
Which medication is known to cause metabolic alkalosis, hypokalemia, and ototoxicity as side effects due to over-diuresis?
Signup and view all the answers
Which medication is an antibody to TNF-alpha given intravenously and is used in the treatment of inflammatory bowel disease?
Which medication is an antibody to TNF-alpha given intravenously and is used in the treatment of inflammatory bowel disease?
Signup and view all the answers
What is the most common side effect associated with iodine contrast?
What is the most common side effect associated with iodine contrast?
Signup and view all the answers
Which medication inhibits aldosterone and can cause metabolic acidosis and hyperkalemia as side effects due to over-diuresis?
Which medication inhibits aldosterone and can cause metabolic acidosis and hyperkalemia as side effects due to over-diuresis?
Signup and view all the answers
What is the first acid-base disorder that occurs in a patient with ASA poisoning?
What is the first acid-base disorder that occurs in a patient with ASA poisoning?
Signup and view all the answers
Which route of drug administration bypasses the liver and has higher bioavailability compared to oral drugs?
Which route of drug administration bypasses the liver and has higher bioavailability compared to oral drugs?
Signup and view all the answers
What is largely responsible for binding drugs such as penicillins and warfarin?
What is largely responsible for binding drugs such as penicillins and warfarin?
Signup and view all the answers
Which drug can displace unconjugated bilirubin from albumin in newborns and should be avoided in this population?
Which drug can displace unconjugated bilirubin from albumin in newborns and should be avoided in this population?
Signup and view all the answers
Which type of drug kinetics involves a constant amount of drug being eliminated regardless of the dose?
Which type of drug kinetics involves a constant amount of drug being eliminated regardless of the dose?
Signup and view all the answers
How many half-lives does it take for a drug to reach steady state?
How many half-lives does it take for a drug to reach steady state?
Signup and view all the answers
What does the volume of distribution of a drug represent?
What does the volume of distribution of a drug represent?
Signup and view all the answers
Which route of administration involves drug absorption based on lipid solubility through the epidermis?
Which route of administration involves drug absorption based on lipid solubility through the epidermis?
Signup and view all the answers
Which type of drug is restricted to nonionized, lipid-soluble drugs for absorption into the cerebrospinal fluid (CSF)?
Which type of drug is restricted to nonionized, lipid-soluble drugs for absorption into the cerebrospinal fluid (CSF)?
Signup and view all the answers
Which drug is stored in bone and follows zero-order kinetics for elimination?
Which drug is stored in bone and follows zero-order kinetics for elimination?
Signup and view all the answers
Which drug has the potential to cause kernicterus in newborns due to displacement of unconjugated bilirubin from albumin?
Which drug has the potential to cause kernicterus in newborns due to displacement of unconjugated bilirubin from albumin?
Signup and view all the answers
What is the fraction of unchanged drug reaching the systemic circulation known as?
What is the fraction of unchanged drug reaching the systemic circulation known as?
Signup and view all the answers
Which drug level is defined as the level at which death occurs in 50% of patients?
Which drug level is defined as the level at which death occurs in 50% of patients?
Signup and view all the answers
What effect is seen at an unusually low dose of a drug?
What effect is seen at an unusually low dose of a drug?
Signup and view all the answers
Which phase of drug metabolism involves demethylation, oxidation, reduction, and hydrolysis reactions?
Which phase of drug metabolism involves demethylation, oxidation, reduction, and hydrolysis reactions?
Signup and view all the answers
Which of the following is an inhibitor of P-450 system?
Which of the following is an inhibitor of P-450 system?
Signup and view all the answers
What is the most important organ for eliminating most drugs?
What is the most important organ for eliminating most drugs?
Signup and view all the answers
What is the end product of purine metabolism that causes gout?
What is the end product of purine metabolism that causes gout?
Signup and view all the answers
What medication binds tubulin and inhibits migration of white blood cells?
What medication binds tubulin and inhibits migration of white blood cells?
Signup and view all the answers
Which lipid-lowering agent binds bile acids in the gut, forcing the body to resynthesize bile acids from cholesterol?
Which lipid-lowering agent binds bile acids in the gut, forcing the body to resynthesize bile acids from cholesterol?
Signup and view all the answers
Which drug is used to treat torsades de pointes (ventricular tachycardia)?
Which drug is used to treat torsades de pointes (ventricular tachycardia)?
Signup and view all the answers
