Questions and Answers
What effect does smoking have on metabolism?
What is the drug classification of Doxepin (Sinequan)?
Which of the following is an indication for Doxepin (Sinequan)?
What are some common side effects of Doxepin (Sinequan)?
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What nursing responsibility is associated with Doxepin (Sinequan) in older adults?
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What is the primary action of Doxepin (Sinequan)?
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In which situations is Doxepin (Sinequan) contraindicated?
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What caution should be taken when prescribing Doxepin (Sinequan)?
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What may happen if Doxepin (Sinequan) is used with MAOIs?
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Study Notes
Doxepin (Sinequan) Overview
- Doxepin is marketed under the name Sinequan.
- Smoking can increase the metabolism of Doxepin.
Drug Classification
- Classified as an antidepressant, anti-anxiety medication, and antihistamine.
- Falls under Category C for pregnancy classification.
- Administered orally (PO).
Indications
- Used to treat depression, anxiety, and insomnia.
Side Effects
- Common side effects include fatigue, sedation, agitation, confusion, blurry vision, and hallucinations.
- Potential complications: increased intraocular pressure, lower blood pressure, arrhythmias, and ECG abnormalities.
- Gastrointestinal side effects such as constipation, dry mouth, and weight gain with increased appetite.
- Other risks include paralytic ileus, urinary retention, reduced libido, photosensitivity, rashes, blood dyscrasias, and hypersensitivity reactions.
Nursing Responsibilities
- For geriatric patients, consider dose reduction.
- Not deemed safe for pediatric patients.
- Monitor for suicidal thoughts and assess cardiovascular history.
- Conduct regular checks on ECG, BP, pulse, weight, BMI, fasting blood sugar, cholesterol, and electrolytes.
- Advise patients to avoid alcohol consumption.
Drug Action
- Doxepin works by potentiating norepinephrine and serotonin levels.
- Exhibits antihistamine and anticholinergic properties.
Contraindications
- Contraindicated in patients with hypersensitivity, angle closure glaucoma, recent myocardial infarction, history of QT prolongation, heart failure, and cardiac arrhythmias.
Caution
- Use with caution in individuals with cardiovascular disease, prostatic enlargement, and history of seizures.
Drug Interactions
- May require dose adjustments when taken with antidepressants, antipsychotics, carbamazepine, and class 1C antiarrhythmics.
- Co-administration with MAOIs can lead to dangerously low blood pressure and increased heart rate.
- Clonidine can precipitate a hypersensitivity crisis.
- Levodopa may reduce Doxepin absorption.
- Increased CNS depression may occur with concurrent use of other depressants.
- Phenothiazines or hormonal contraceptives may raise Doxepin levels.
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Description
Test your knowledge about Doxepin (Sinequan) with these flashcards. Covering key points such as drug classification, indications, and side effects, this quiz is designed for students and healthcare professionals alike. Enhance your understanding of this medication's uses and effects.
