Dose-Response Curve

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Questions and Answers

Which of the following statements accurately describes the dose-response curve for the analgesic effect of morphine?

The curve represents the difference between the therapeutic and adverse effects of the drug.
The curve indicates the drug's margin of safety. (correct)
The curve shows the drug's therapeutic effects on respiration.
The curve shows the drug's adverse side effects on respiration.

What does a drug's margin of safety indicate?

The difference between the analgesic and depressant effects of the drug.
The measure of the drug's therapeutic index.
The ratio of the toxic dose to the effective dose of the drug.
The difference between the therapeutic and adverse effects of the drug. (correct)

What is the therapeutic index of a drug?

The difference between the dose-response curves for analgesic and depressant effects of the drug.
The difference between the toxic and effective doses of the drug.
The ratio of the dose that produces analgesia to the dose that depresses heart rate and respiration.
The ratio of the dose that produces desired effects to the dose that produces toxic effects in 50 percent of the animals. (correct)

Which of the following best describes the compensatory mechanisms discussed in the text?

They decrease the effectiveness of drug binding with receptors (A) Signup and view all the answers

What is the difference between tolerance and sensitization?

Tolerance occurs when larger doses of a drug are needed to achieve the same effect, while sensitization occurs when smaller doses of a drug are needed to achieve a larger effect (D) Signup and view all the answers

What is the purpose of using placebos in drug research?

To determine if a drug has a specific physiological effect (A) Signup and view all the answers

What is a withdrawal symptom?

The appearance of symptoms opposite to those produced by a drug when it is administered repeatedly (D) Signup and view all the answers

Which of the following best describes the therapeutic index of a drug?

The ratio between the dose that produces the desired effect in 50 percent of the animals and the dose that produces toxic effects in 50 percent of the animals. (C) Signup and view all the answers

Why is an accidental overdose of a barbiturate more likely to have tragic effects than a similar overdose of Valium?

Barbiturates have a lower therapeutic index than Valium. (D) Signup and view all the answers

What are the two reasons that drugs vary in their effectiveness?

Different drugs may have different sites of action and different affinities for their binding sites. (D) Signup and view all the answers

What is the difference between tolerance and sensitization?

Tolerance is a decrease in the effectiveness of a drug that is administered repeatedly, while sensitization is an increase in the effectiveness of a drug that is administered repeatedly. (C) Signup and view all the answers

Flashcards

Dose-response curve (morphine)

Shows how the analgesic effect of morphine changes with different doses.

Margin of safety

Difference between a drug's therapeutic effect and harmful effect.