Dose-Response Curve
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Questions and Answers

Which of the following statements accurately describes the dose-response curve for the analgesic effect of morphine?

  • The curve represents the difference between the therapeutic and adverse effects of the drug.
  • The curve indicates the drug's margin of safety. (correct)
  • The curve shows the drug's therapeutic effects on respiration.
  • The curve shows the drug's adverse side effects on respiration.

    • What does a drug's margin of safety indicate?

  • The difference between the analgesic and depressant effects of the drug.
  • The measure of the drug's therapeutic index.
  • The ratio of the toxic dose to the effective dose of the drug.
  • The difference between the therapeutic and adverse effects of the drug. (correct)

    • What is the therapeutic index of a drug?

  • The difference between the dose-response curves for analgesic and depressant effects of the drug.
  • The difference between the toxic and effective doses of the drug.
  • The ratio of the dose that produces analgesia to the dose that depresses heart rate and respiration.
  • The ratio of the dose that produces desired effects to the dose that produces toxic effects in 50 percent of the animals. (correct)

    • Which of the following best describes the compensatory mechanisms discussed in the text?

    <p>They decrease the effectiveness of drug binding with receptors</p> Signup and view all the answers

    What is the difference between tolerance and sensitization?

    <p>Tolerance occurs when larger doses of a drug are needed to achieve the same effect, while sensitization occurs when smaller doses of a drug are needed to achieve a larger effect</p> Signup and view all the answers

    What is the purpose of using placebos in drug research?

    <p>To determine if a drug has a specific physiological effect</p> Signup and view all the answers

    What is a withdrawal symptom?

    <p>The appearance of symptoms opposite to those produced by a drug when it is administered repeatedly</p> Signup and view all the answers

    Which of the following best describes the therapeutic index of a drug?

    <p>The ratio between the dose that produces the desired effect in 50 percent of the animals and the dose that produces toxic effects in 50 percent of the animals.</p> Signup and view all the answers

    Why is an accidental overdose of a barbiturate more likely to have tragic effects than a similar overdose of Valium?

    <p>Barbiturates have a lower therapeutic index than Valium.</p> Signup and view all the answers

    What are the two reasons that drugs vary in their effectiveness?

    <p>Different drugs may have different sites of action and different affinities for their binding sites.</p> Signup and view all the answers

    What is the difference between tolerance and sensitization?

    <p>Tolerance is a decrease in the effectiveness of a drug that is administered repeatedly, while sensitization is an increase in the effectiveness of a drug that is administered repeatedly.</p> Signup and view all the answers

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