Dose Response Curve: Definition and Characteristics

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What is the characteristic of a drug that has a higher efficacy?

Having a wider therapeutic index

Giving a response that cannot be produced by another drug of a lower efficacy (correct)

Producing the same response with a higher dose

Having a steeper slope in the dose-response curve

Which of the following best describes the importance of efficacy for a physician and patient?

It is a more important drug characteristic than potency (correct)

It is a measure of the safety of the drug

It is a measure of the biological variation of the drug

It is a measure of the potency of the drug

What is the primary purpose of a dose response curve?

To determine the potency of a drug

To calculate the ED50 of a drug

To compare the efficacy of different drugs

To demonstrate the relationship between the doses of a drug and the responses produced by these doses (correct)

What is indicated by a steep slope in the dose-response curve?

A narrow margin of safety (D) Signup and view all the answers

What is the term for the variation in response to a drug among different individuals or in the same individual over time?

Biological variation (D) Signup and view all the answers

What is represented on the x-axis of a dose response curve?

Potency (A) Signup and view all the answers

Which of the following factors contributes to biological variation?

Age of the individual (A) Signup and view all the answers

What is the importance of potency in clinical practice?

It has little clinical significance, but low potency is a disadvantage if the dose is too large (D) Signup and view all the answers

What is the median effective dose (ED50)?

The dose at which 50% of the population or sample manifests a given effect (D) Signup and view all the answers

What is represented by the horizontal bracket in the expression of biological variation?

A certain response that can be achieved by a range of doses (D) Signup and view all the answers

What is efficacy in the context of a dose response curve?

The relative ability of a drug to produce a maximum functional response (B) Signup and view all the answers

What is the characteristic of a highly potent drug?

It produces a maximum functional response at low concentrations (C) Signup and view all the answers

What is the interval of time between doses in the preparation of a dose response curve for Epinephrine?

30 minutes (A) Signup and view all the answers

What is the primary purpose of preparing a dose response curve?

To determine the relationship between the dose of a drug and its response (A) Signup and view all the answers

Which of the following is a characteristic of a dose response curve?

The response increases with an increase in dose (D) Signup and view all the answers

What is the ED50 of a drug?

The dose of the drug that produces 50% of the maximum response (A) Signup and view all the answers

Which of the following is a measure of a drug's efficacy?

The maximum response produced by the drug (D) Signup and view all the answers