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Questions and Answers
What is the difference between N-linked and O-linked glycosylation?
What is the difference between N-linked and O-linked glycosylation?
- N-linked glycosylation adds sugars sequentially to the polypeptide chain, while O-linked glycosylation adds sugars one at a time.
- N-linked glycosylation adds sugars one at a time to the polypeptide chain, while O-linked glycosylation adds a whole bunch of sugars. (correct)
- N-linked glycosylation adds a whole bunch of sugars to the polypeptide chain, while O-linked glycosylation adds sugars sequentially.
- N-linked glycosylation and O-linked glycosylation are the same process.
Which molecule is responsible for transferring sugars from the cytosol to the ER lumen?
Which molecule is responsible for transferring sugars from the cytosol to the ER lumen?
- Glucose
- Mannose
- Dolichol phosphate (correct)
- N-acetylglucosamine
What is the role of the protein that can flip the dolichol phosphate?
What is the role of the protein that can flip the dolichol phosphate?
- To transfer sugars from the cytosol to the ER lumen (correct)
- To break down the dolichol phosphate
- To transfer sugars from the ER lumen to the cytosol
- To attach the dolichol phosphate to the polypeptide chain
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Study Notes
Glycosylation Types
- N-linked glycosylation: occurs in the endoplasmic reticulum (ER) and involves the attachment of a carbohydrate molecule to an asparagine residue in a protein
- O-linked glycosylation: occurs in the Golgi apparatus and involves the attachment of a carbohydrate molecule to a serine or threonine residue in a protein
Glycosylation Process
- The molecule responsible for transferring sugars from the cytosol to the ER lumen is oligosaccharyltransferase (OST)
- Oligosaccharyltransferase (OST) transfers a pre-assembled oligosaccharide from dolichol phosphate to the asparagine residue of a protein
Dolichol Phosphate Function
- The protein that can flip dolichol phosphate is called flippase
- Flippase is responsible for flipping dolichol phosphate from the cytosolic side to the luminal side of the ER, allowing the transfer of sugars to occur
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