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Questions and Answers
What role does helicase play in DNA replication?
What role does helicase play in DNA replication?
Which enzyme is responsible for preventing the overwinding of DNA during replication?
Which enzyme is responsible for preventing the overwinding of DNA during replication?
In what manner is the leading strand synthesized during DNA replication?
In what manner is the leading strand synthesized during DNA replication?
What are Okazaki fragments?
What are Okazaki fragments?
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What describes semi-conservative replication?
What describes semi-conservative replication?
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Study Notes
DNA Replication
- DNA replication is the process of duplicating DNA.
- It occurs during the S phase of the cell cycle.
- It requires 5 key enzymes.
Enzymes in DNA Replication
- Helicase: Unwinds the DNA double helix.
- Topoisomerase: Prevents the recoiling of DNA strands.
- Primase: Adds RNA primers to initiate DNA synthesis.
- DNA Polymerase: Synthesizes new DNA strands in the 5' to 3' direction.
- Ligase: Joins Okazaki fragments on the lagging strand.
Leading and Lagging Strands
- Leading strand: Synthesized continuously from the 5' to 3' direction.
- Lagging strand: Synthesized discontinuously in short fragments (Okazaki fragments) from the 3' to 5' direction.
Origin of Replication
- Replication starts at specific sites called origins of replication.
Semi-Conservative Replication
- Each new DNA molecule consists of one original strand and one new strand. This is called semi-conservative replication.
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Description
Explore the intricate process of DNA replication, including the key enzymes involved and the distinction between leading and lagging strands. Understand the significance of semi-conservative replication and the origins of replication necessary for DNA synthesis.
