Lect. 6

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What is the function of Replicative recombination?

Generates a new copy of a DNA segment

What can be detected using the Recombination Detection Program (RDP)?

Recombination

Recombination of DNA always requires specific enzymatic machinery for each particular site.

False

Recombination allows nonfunctional alleles to be preserved in a population.

False

Advantages of genetic recombination include separation of alleles over time.

False

Without recombination, a deleterious mutant allele would cause an entire chromosome to be eliminated from the population.

True

Replicative recombination is catalyzed by a specific enzyme that recognizes a short sequence present in the target site in the bacterial chromosome.

True

Recombination can only occur at the DNA level for viruses.

False

Recombination by independent assortment can occur among viruses with non-segmented genomes.

False

Homologous recombination occurs between DNA with extensive sequence homology anywhere within the homology.

True

Site-specific recombination occurs between DNA with extensive sequence homology.

False

Recombination leads to the generation of viruses with new antigenic determinants through dependent assortment.

False

What is the outcome of genetic recombination in viruses?

A new genetic entity with non-parental genetic combinations

What is the difference between homologous and site-specific recombination?

Homologous recombination occurs between DNA with extensive sequence homology, while site-specific recombination occurs between DNA with no extensive homology

What type of recombination can lead to the generation of viruses with new antigenic determinants and new host ranges?

Recombination by independent assortment

Study Notes

Recombination of DNA: Types and Examples

  • Gene C is now located on the same chromosome as genes D and E
  • Two types of recombination: Homologous recombination and nonhomologous recombination
  • Site-specific recombination occurs between particular short sequences present on dissimilar parental molecules
  • Site-specific recombination requires specific enzymatic machinery for each particular site
  • Replicative recombination generates a new copy of a DNA segment
  • Recombination can be detected using the Recombination Detection Program (RDP)
  • Advantages of genetic recombination include DNA homogenization, new allele combinations, and separation of alleles over time
  • Disadvantages of genetic recombination include separation of advantageous traits and important gene combinations in offspring
  • Recombination allows nonfunctional alleles to be cleared from a population and rare beneficial alleles to be tested
  • Without recombination, a deleterious mutant allele would cause an entire chromosome to be eliminated from the population
  • Recombinational events can be detected in natural populations, such as a recombinant dengue virus type 1 with three recombination regions in Guangdong province, China
  • Replicative recombination is catalyzed by a specific enzyme that recognizes a short sequence present in the target site in the bacterial chromosome.

Recombination of DNA: Types and Examples

  • Gene C is now located on the same chromosome as genes D and E
  • Two types of recombination: Homologous recombination and nonhomologous recombination
  • Site-specific recombination occurs between particular short sequences present on dissimilar parental molecules
  • Site-specific recombination requires specific enzymatic machinery for each particular site
  • Replicative recombination generates a new copy of a DNA segment
  • Recombination can be detected using the Recombination Detection Program (RDP)
  • Advantages of genetic recombination include DNA homogenization, new allele combinations, and separation of alleles over time
  • Disadvantages of genetic recombination include separation of advantageous traits and important gene combinations in offspring
  • Recombination allows nonfunctional alleles to be cleared from a population and rare beneficial alleles to be tested
  • Without recombination, a deleterious mutant allele would cause an entire chromosome to be eliminated from the population
  • Recombinational events can be detected in natural populations, such as a recombinant dengue virus type 1 with three recombination regions in Guangdong province, China
  • Replicative recombination is catalyzed by a specific enzyme that recognizes a short sequence present in the target site in the bacterial chromosome.

Test your knowledge of DNA recombination with this quiz covering types, examples, and the impact of genetic recombination on populations. Explore concepts such as homologous recombination, site-specific recombination, replicative recombination, and the advantages and disadvantages of genetic recombination.

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