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Questions and Answers
Which type of DNA damage can be caused by replication errors?
Which type of DNA damage can be caused by replication errors?
- Abasic sites
- Single strand break
- Insertion/Deletion (correct)
- UV radiation
Which DNA repair mechanism is responsible for repairing single strand breaks?
Which DNA repair mechanism is responsible for repairing single strand breaks?
- Nucleotide Excision Repair
- Base Excision Repair
- Photoreactivation
- Mismatch Repair (correct)
Which type of DNA damage can be caused by ionizing radiation?
Which type of DNA damage can be caused by ionizing radiation?
- Double strand break (correct)
- UV radiation
- Single strand break
- Replication error
Which DNA repair mechanism is responsible for repairing UV radiation-induced DNA damage?
Which DNA repair mechanism is responsible for repairing UV radiation-induced DNA damage?
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Which type of DNA damage can be caused by oxidative stress?
Which type of DNA damage can be caused by oxidative stress?
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Study Notes
Types of DNA Damage
- Replication errors can cause mismatch repair, which results in incorrect base pairing
- Ionizing radiation can cause double-strand breaks in DNA
- UV radiation can cause thymine-thymine dimers, which are a type of DNA lesion
DNA Repair Mechanisms
- Single-strand breaks are repaired by the base excision repair (BER) pathway
- UV radiation-induced DNA damage is repaired by the nucleotide excision repair (NER) pathway
- Oxidative stress can cause oxidative lesions, such as 8-oxoG, which are repaired by the base excision repair (BER) pathway
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