Diuretics: Thiazide and Loop

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Questions and Answers

A client with heart failure is prescribed furosemide. Which parameter should the nurse prioritize monitoring to prevent a potential adverse effect of this medication?

  • Blood glucose levels
  • Serum potassium levels (correct)
  • Intracranial pressure
  • Uric acid levels

A patient with a history of asthma is prescribed albuterol. The nurse should educate the patient to recognize and report which potential adverse effect indicating excessive sympathetic stimulation?

  • Tremors and palpitations (correct)
  • Muscle weakness and polyuria
  • Bradycardia and hypotension
  • Lethargy and constipation

A patient with COPD is prescribed ipratropium. Which assessment finding would warrant caution by the nurse before administering this medication?

  • Presence of clear sputum production
  • Reports of occasional dry mouth
  • History of glaucoma (correct)
  • Complaints of mild constipation

A client with asthma is prescribed budesonide via inhalation. What instruction should the nurse provide to minimize the risk of a common adverse effect?

<p>Rinse mouth with water after each use. (B)</p> Signup and view all the answers

A patient is prescribed theophylline for chronic bronchitis. The nurse understands that which substance can significantly alter the drug's therapeutic level, potentially leading to toxicity?

<p>Cigarette smoke (D)</p> Signup and view all the answers

A patient taking spironolactone for heart failure should be educated to limit the intake of foods high in potassium to prevent which potential adverse effect?

<p>Hyperkalemia (B)</p> Signup and view all the answers

A patient with cerebral edema is prescribed mannitol. Which assessment finding would indicate a therapeutic effect of this medication?

<p>Decreased intracranial pressure (D)</p> Signup and view all the answers

A patient with nasal congestion due to a cold is considering using pseudoephedrine. The nurse should advise caution in patients with which coexisting condition?

<p>Hypertension (C)</p> Signup and view all the answers

A patient with allergic rhinitis is prescribed diphenhydramine. The nurse should include which instruction in the patient's education to address a common adverse effect?

<p>Increase fluid intake and use frequent mouth care. (B)</p> Signup and view all the answers

A patient with a persistent cough is prescribed guaifenesin. The nurse assesses the patient understands that guaifenesin helps with their cough by which mechanism?

<p>Reducing the viscosity of mucus (B)</p> Signup and view all the answers

A nurse is teaching a client who is starting on hydrochlorothiazide for hypertension. What important dietary consideration should the nurse include in the teaching?

<p>Increase potassium intake (C)</p> Signup and view all the answers

Which of the following assessment findings would be most concerning in a patient receiving mannitol?

<p>New onset of pulmonary congestion (C)</p> Signup and view all the answers

A patient with asthma is using albuterol inhaler. After administering the medication, the nurse assesses the patient and finds an increased heart rate and feelings of anxiety. What is the appropriate nursing intervention?

<p>Instruct the patient that these are expected side effects and will subside (C)</p> Signup and view all the answers

A female client taking spironolactone reports increased facial hair and breast tenderness. What is the nurse's best response?

<p>“These are possible side effects of the medication and should be reported to your doctor but are not life threatening.” (C)</p> Signup and view all the answers

A patient is prescribed zafirlukast for asthma. What important instruction should the nurse provide regarding when to take this medication?

<p>Take it on an empty stomach, 1 hour before or 2 hours after meals (C)</p> Signup and view all the answers

A patient is receiving theophylline intravenously for severe bronchospasm. Which sign or symptom would indicate the patient is experiencing theophylline toxicity?

<p>Nausea, vomiting and restlessness (D)</p> Signup and view all the answers

Which diuretic is most likely to cause ototoxicity if administered at high doses or in conjunction with other ototoxic medications?

<p>Furosemide (C)</p> Signup and view all the answers

A patient with a history of heart failure and renal dysfunction is prescribed a diuretic. Which diuretic would be contraindicated or require careful monitoring due to its potassium-sparing effect?

<p>Spironolactone (D)</p> Signup and view all the answers

A patient reports using an over-the-counter decongestant containing pseudoephedrine. Which pre-existing condition should prompt the nurse to advise the patient to discontinue using the medication?

<p>Uncontrolled hypertension (D)</p> Signup and view all the answers

A patient receiving mannitol reports headache and nausea. The nurse should assess the patient for other signs and symptoms of which potential complication?

<p>Fluid and electrolyte imbalance (D)</p> Signup and view all the answers

A patient with chronic bronchitis is prescribed theophylline. What specific dietary instruction should the nurse provide to the patient to prevent potential complications?

<p>Avoid caffeine-containing beverages and foods (B)</p> Signup and view all the answers

A patient with asthma is prescribed both albuterol and budesonide inhalers. How should the nurse instruct the patient to use these medications?

<p>Use albuterol first, then budesonide after 5 minutes (B)</p> Signup and view all the answers

A patient taking diphenhydramine for allergic rhinitis reports experiencing significant drowsiness. What safety measure should the nurse emphasize to this patient?

<p>Avoid alcohol and other CNS depressants (A)</p> Signup and view all the answers

A patient with a productive cough is prescribed guaifenesin. The nurse should emphasize which non-pharmacological measure to enhance the effectiveness of this medication?

<p>Increase fluid intake to help liquefy secretions (A)</p> Signup and view all the answers

The nurse is caring for a client who is administered mannitol. What is the primary mechanism by which mannitol reduces intracranial pressure?

<p>By drawing fluid from the brain tissue into the bloodstream (A)</p> Signup and view all the answers

Flashcards

Thiazide Diuretics Action

Inhibits Na+ and Cl- reabsorption in distal tubules, increasing excretion of Na+, Cl-, and H2O.

Thiazide Diuretics Indications

Edema with HF, cirrhosis, hypertension, and renal dysfunction.

Thiazide Diuretics: Adverse Effects

Dizziness, orthostatic hypotension, hypokalemia, dehydration, muscle cramps.

Loop Diuretics Action

Inhibits Na+ and Cl- reabsorption in the loop of Henle, causing Na+-rich diuresis.

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Loop Diuretics Indications

Edema with HF and acute pulmonary edema

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Loop Diuretics: Adverse Effects

Orthostatic hypotension, hypokalemia, hyperuricemia, dehydration, ototoxicity.

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Potassium-Sparing Diuretics Action

Competitively blocks aldosterone, causing Na+ and H2O loss while retaining K+.

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Potassium-Sparing Diuretics Indications

Edema with HF, nephrotic syndrome, and ascites with cirrhosis.

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Potassium-Sparing Diuretics: Adverse Effects

Hyperkalemia, hirsutism/gynecomastia.

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Osmotic Diuretics Action

Elevates filtrate osmolarity, leading to Na+, H2O, and Cl- loss.

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Osmotic Diuretics Indications

Oliguria in renal failure and reducing ICP and cerebral edema.

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Osmotic Diuretics: Adverse Effects

Hypotension, fluid/electrolyte imbalances, acute HF, acute pulmonary edema.

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Decongestants Action

Vasoconstriction in nasal mucous membranes improving drainage and ventilation.

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Decongestants Indications

Nasal congestion, sinusitis, colds, hay fever, eustachian tube congestion.

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Decongestants: Adverse Effects

Seizures, HTN, arrhythmias, urinary retention, respiratory difficulty.

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Antihistamines Action

Blocks histamine at H1 receptor sites.

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Antihistamines Indications

Rhinitis, urticaria, angioedema, parkinsonism.

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Antihistamines: Adverse Effects

Sedation, thick bronchial secretions, urinary retention, bradycardia.

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Expectorants Action

Enhances respiratory tract fluid output, reducing adhesiveness of mucus.

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Expectorants Indications

Relief of respiratory conditions by thinning mucus secretions.

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Expectorants: Adverse Effects

Nausea, vomiting, dizziness.

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Xanthines Action

Relaxes bronchial smooth muscle causing bronchodilation.

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Xanthines Indications

Bronchospasm in asthma, bronchitis, and emphysema.

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Xanthines: Adverse Effects

Palpitations, arrhythmias, proteinuria, respiratory arrest.

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Sympathomimetics Action

Reacts at beta-receptor sites causing bronchodilation, increased HR, RR, BP.

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Study Notes

  • Diuretics increase the excretion of water from the body

Thiazide/Thiazide-Like Diuretics (Hydrochlorothiazide)

  • Inhibits sodium and chloride reabsorption in distal renal tubules.
  • Increases excretion of sodium, chloride, and water.
  • Treats edema with heart failure, cirrhosis, hypertension, and renal dysfunction.
  • Be cautious with allergies to thiazide or sulfa medications, hypovolemia, severe renal disease, lupus, glucose abnormalities, and gout.
  • Adverse effects: dizziness, orthostatic hypotension, hypokalemia, nausea, vomiting, diarrhea, dehydration, polyuria/nocturia, muscle cramps/spasms.
  • Drug interaction: increases digoxin toxicity due to potassium loss.

Loop Diuretics (Furosemide)

  • Acts on the loop of Henle.
  • Inhibits sodium and chloride reabsorption in distal renal tubules and the loop of Henle, resulting in sodium-rich diuresis.
  • Treats edema with heart failure and acute pulmonary edema.
  • Use cautiously in patients with electrolyte depletion and anuria.
  • Adverse effects: orthostatic hypotension, hypokalemia, hyperuricemia, dehydration, ototoxicity.

Potassium-Sparing Diuretics (Spironolactone)

  • Blocks aldosterone effects in the renal tubule, causing sodium and water loss while retaining potassium.
  • Treats edema in heart failure, nephrotic syndrome, and ascites with cirrhosis.
  • Be cautious with severe renal disease, anuria, and hyperkalemia.
  • Adverse effects: hyperkalemia, hirsutism/gynecomastia.
  • Avoid foods high in potassium.
  • High potassium foods include avocados, bananas, broccoli, cantaloupe, dried fruits, grapefruit, lima beans, nuts, navy beans, orange, peaches, potatoes, prunes, decaffeinated coffee, spinach, sunflower seeds, tomatoes, watermelon, and rhubarb.

Osmotic Diuretics (Mannitol)

  • Elevates the similarity of the glomerular filtration, leading to loss of sodium, water, and chloride.
  • Treats the oliguria phase in renal failure, reduces intracranial pressure, and treats cerebral edema.
  • Be cautious with allergies, severe renal disease, anuria, pulmonary congestion, intracranial bleeding, dehydration, and heart failure.
  • Adverse effects: hypotension, fluid and electrolyte imbalances, acute heart failure, acute pulmonary edema.
  • Administer via IV infusion only, using a filter.
  • Keep vials warm to prevent crystallization.

Nursing Management and Implications for Diuretics

  • Obtain thorough patient history and conduct a physical exam.
  • Monitor baseline fluid status daily, including input/output.
  • Monitor baseline chemistry and electrolyte values regularly during treatment.
  • Administer diuretics in the morning.
  • Patients may need to increase protein intake, except with potassium-sparing diuretics.
  • Monitor for digitalis toxicity if the patient is also taking digitalis for heart disease.
  • Teach patients to change positions slowly to avoid orthostatic hypotension.
  • Encourage patients to keep a log of their daily weights every morning.
  • Remind patients to attend follow-up visits and lab work.
  • Instruct patients to notify their healthcare provider if they experience nausea, vomiting, or diarrhea due to the risk of fluid and electrolyte imbalances.
  • Signs and symptoms of hypokalemia include muscle weakness, constipation, irregular pulse rate, and lethargy.
  • Instruct patients to notify their healthcare provider immediately if they experience a rapid heart rate.

Decongestants (Pseudoephedrine)

  • Has sympathomimetic effects, causing vasoconstriction in the mucous membranes of the nasal passages to improve drainage and ventilation.
  • Treats nasal congestion, sinusitis, colds, hay fever, and eustachian tube congestion.
  • Be cautious with conditions exacerbated by sympathetic activity (hypertension/cardiac disease).
  • Adverse effects: seizures, hypertension, arrhythmias, urinary retention, respiratory difficulty.

Antihistamines (Diphenhydramine)

  • Competitively blocks histamine effects at H1 receptor sites.
  • Treats rhinitis, urticaria, angioedema, and parkinsonism.
  • Use cautiously in renal/hepatic impairment, history of arrhythmias, and prolonged QT intervals.
  • Adverse effects: sedation, thick bronchial secretions, urinary retention, bradycardia.
  • Administer IV for angioedema and IM.
  • Assess the condition or reaction and drug allergies.
  • Contraindicated in acute asthma attacks or lower respiratory diseases like pneumonia.
  • Use cautiously in cardiac/hypertension, renal disease, COPD, or pregnancy.
  • Assess and educate about excessive sedation.
  • Avoid driving, alcohol, and CNS depressants.
  • Best taken with meals.
  • Frequent mouth care is needed due to dry mouth.

Expectorants (Guaifenesin)

  • Enhances respiratory tract fluid output by reducing the adhesiveness of the fluid, which removes viscous mucus.
  • Provides relief from respiratory conditions by thinning mucous secretions, allowing them to be cleared.
  • Use cautiously in older adults and patients with asthma and respiratory insufficiency.
  • Caution for allergy, persistent cough.
  • Adverse effects: nausea, vomiting, dizziness.
  • Patients taking expectorants should increase fluid intake to help liquefy secretions.
  • Report fever, cough, or other symptoms lasting longer than one week.
  • Monitor for the intended therapeutic effect.

Xanthines (Theophylline)

  • Relaxes bronchial smooth muscle, causing bronchodilation.
  • Provides relief and prevention of bronchospasm in asthma, chronic bronchitis, and emphysema (COPD).
  • Be cautious with GI problems, coronary disease, and alcoholism.
  • Adverse effects: palpitations, life-threatening arrhythmias, proteinuria, respiratory arrest.
  • Toxicity can lead to life-threatening arrhythmias, seizures, and hypotension.
  • Drug interaction: cigarette smoking reduces levels of theophylline.
  • Administered acutely via IV.
  • Therapeutic levels: 10-20 mcg/mL.

Sympathomimetics (Albuterol)

  • Acts as an agonist at beta-receptor sites in the SNS, causing bronchodilation and increased heart rate, respiratory rate, and blood pressure.
  • Treats bronchospasm and prevents exercise-induced bronchospasm.
  • Cautious use depends on the severity of underlying conditions aggravated by sympathetic stimulation.
  • Adverse effects: fear, anxiety, restlessness, headache, sore throat, paradoxical bronchospasm, arrhythmias, hypertension, angina.
  • Administered via inhalation.

Anticholinergics (Ipratropium)

  • Blocks acetylcholine action, causing smooth muscle relaxation and bronchodilation.
  • Provides maintenance for bronchospasm in COPD.
  • Be cautious with conditions aggravated by anticholinergic or atropine-like effects, such as bladder obstruction and glaucoma.
  • Adverse effects: dizziness, palpitations, ocular changes, urinary changes, urinary retention, paradoxical bronchospasm, dry mouth.

Inhaled Steroids (Budesonide)

  • Decreases the inflammatory response in the airway.
  • Used for the prevention and treatment of asthma.
  • NOT for emergency use; avoid in active infections of the respiratory system.
  • Adverse effects: fungal infections (pharyngeal and laryngeal), so patients need to rinse their mouth after use.

Leukotriene Receptor Antagonist (Zafirlukast)

  • Blocks receptors for leukotrienes, preventing airways edema.
  • Used for the prevention and treatment of asthma.
  • NOT for emergency use; use cautiously in hepatic/renal impairment.
  • Adverse effects: headache, dizziness, nausea, fever/pain, infection, hepatotoxicity, rash, kidney and liver issues, neuropsychiatric events.

Nursing Management for Respiratory Medications

  • Assess for improved air movement, medication or environmental allergies (triggers), and contraindications (cardiac concerns).
  • Assess for cough symptoms and knowledge of the underlying issue and medications being used.
  • Implement monitoring, such as pulse oximetry.
  • Teach patients about avoiding triggers, the treatment plan, and medication information.
  • Provide patient teaching on the proper use of inhalers, spacers, or nebulizers.
  • Collaborate with respiratory therapy colleagues.
  • Avoid caffeine.

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