Diuretics: Mechanism of Action Quiz
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Questions and Answers

What is the primary mechanism of action of thiazide diuretics?

  • Inhibit sodium reabsorption in the proximal tubules (correct)
  • Increase sodium and water reabsorption in the distal tubules
  • Have no effect on sodium reabsorption
  • Activate the Na-Cl cotransport system
  • Which thiazide diuretic also has calcium channel blocking activity?

  • Hydrochlorothiazide
  • Indapamide (correct)
  • Chlorthalidone
  • None of the above
  • What is the long-term antihypertensive effect of thiazide diuretics primarily attributed to?

  • Increased PVR (correct)
  • Activation of the renin-angiotensin-aldosterone system
  • Upregulation of vasopressor agents
  • Decreased sodium excretion
  • What is the main use of thiazide diuretics in the treatment of kidney stones?

    <p>Promoting the excretion of calcium stones</p> Signup and view all the answers

    Which side effect is commonly associated with thiazide diuretics?

    <p>Hypokalemia</p> Signup and view all the answers

    What is the primary mechanism through which thiazide diuretics decrease blood pressure?

    <p>Inhibition of sodium reabsorption in the distal tubules</p> Signup and view all the answers

    Which of the following is NOT a use of thiazide diuretics?

    <p>Heart failure</p> Signup and view all the answers

    How does Chlorthalidone differ from other thiazide diuretics?

    <p>It has a long duration of action</p> Signup and view all the answers

    What is the main side effect associated with thiazide diuretics?

    <p>Hypokalemia</p> Signup and view all the answers

    In addition to decreasing blood pressure, what is another long-term effect of thiazide diuretics related to their antihypertensive effect?

    <p>Decreased peripheral vascular resistance</p> Signup and view all the answers

    Which type of adrenergic receptor blockers is phenoxybenzamine classified as?

    <p>Nonselective α receptor blockers</p> Signup and view all the answers

    What is the primary long-term effect of phenoxybenzamine related to its antihypertensive action?

    <p>Peripheral vascular resistance</p> Signup and view all the answers

    In addition to decreasing blood pressure, what is another effect of phenoxybenzamine's action on adrenergic receptors?

    <p>Tachycardia</p> Signup and view all the answers

    What is the primary mechanism through which phenoxybenzamine decreases blood pressure?

    <p>Peripheral vascular resistance</p> Signup and view all the answers

    What is the main use of phenoxybenzamine in medical treatment?

    <p>Treatment of pheochromocytoma</p> Signup and view all the answers

    Study Notes

    Thiazide Diuretics

    • The primary mechanism of action of thiazide diuretics is to inhibit the Na-Cl symporter in the distal convoluted tubule, leading to increased excretion of sodium and water.
    • Hydrochlorothiazide is a thiazide diuretic that also has calcium channel blocking activity.
    • The long-term antihypertensive effect of thiazide diuretics is primarily attributed to their ability to reduce peripheral vascular resistance.
    • The main use of thiazide diuretics in the treatment of kidney stones is to reduce the excretion of calcium in the urine.
    • A common side effect associated with thiazide diuretics is hypokalemia (low potassium levels).
    • Thiazide diuretics decrease blood pressure primarily by reducing sodium reabsorption in the kidneys, leading to a decrease in blood volume and cardiac output.
    • Thiazide diuretics are not typically used to treat heart failure.
    • Chlorthalidone differs from other thiazide diuretics in its longer duration of action.
    • The main side effect associated with thiazide diuretics is hypokalemia (low potassium levels).
    • In addition to decreasing blood pressure, another long-term effect of thiazide diuretics related to their antihypertensive effect is to reduce the risk of cardiovascular disease.

    Phenoxybenzamine

    • Phenoxybenzamine is classified as a non-selective alpha-adrenergic receptor blocker.
    • The primary long-term effect of phenoxybenzamine related to its antihypertensive action is to reduce peripheral vascular resistance.
    • In addition to decreasing blood pressure, phenoxybenzamine's action on adrenergic receptors also leads to a decrease in cardiac output.
    • Phenoxybenzamine decreases blood pressure primarily by blocking alpha-1 receptors, leading to vasodilation.
    • The main use of phenoxybenzamine in medical treatment is to treat pheochromocytoma, a rare tumor of the adrenal gland.

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    Description

    Test your knowledge of diuretics and their mechanism of action with this quiz. Learn about how diuretics such as Thiazides decrease blood pressure by inhibiting sodium reabsorption in the distal tubules.

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