Diuretic Medications Overview

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Questions and Answers

Which diuretic inhibits the action of aldosterone and leads to the excretion of Na and H?

  • Mercaptomerin
  • Dextrose
  • Caffeine
  • Amiloride (correct)

What is the potential drawback of arteriolar vasodilation mentioned in the text?

  • Pooling of blood in the veins (correct)
  • Increased blood pressure
  • Veins constricting excessively
  • Decreased blood flow to organs

Which aquaporins facilitate the movement of water from the tubule lumen into the bloodstream?

  • Aquaporin-4
  • Aquaporin-1
  • Aquaporin-3
  • Aquaporin-2 (correct)

Which compound resembles progesterone and inhibits aldosterone while promoting potassium retention?

<p>Spironolactone (B)</p> Signup and view all the answers

Which of the following is classified as an osmotic diuretic?

<p>Mannose (B)</p> Signup and view all the answers

What is the main effect of imidazoline-1 receptor agonists like Clonidine?

<p>Antihypertensive effect (C)</p> Signup and view all the answers

What is the main effect of high ceiling diuretics on the body?

<p>Cause hypokalemia (B)</p> Signup and view all the answers

Which part of the body is affected by ototoxicity caused by high ceiling diuretics?

<p>Cochlea (B)</p> Signup and view all the answers

Which type of diuretic is considered obsolete due to its potential to rupture the ear?

<p>Phenoxyacetic acid derivatives (C)</p> Signup and view all the answers

What is the typical onset of action for high ceiling diuretics?

<p>30 minutes (D)</p> Signup and view all the answers

Which ion reabsorption is inhibited by thiazide diuretics?

<p>Na+, K+, Mg2+, Ca2+, and Cl- (B)</p> Signup and view all the answers

How can ineffective pumping by the right heart lead to fluid leakage into lung tissues?

<p>By causing increased blood pressure in the blood vessels of the lungs (A)</p> Signup and view all the answers

Which part of the ECG records the ventricular depolarization?

<p>QRS complex (D)</p> Signup and view all the answers

During which phase of the cardiac cycle does rapid depolarization occur?

<p>Phase 0 (C)</p> Signup and view all the answers

Which class of antiarrhythmic drugs includes Amiodarone?

<p>Class III (K+ channel blockers) (B)</p> Signup and view all the answers

What does the T wave in the ECG represent?

<p>Ventricular repolarization (A)</p> Signup and view all the answers

Which phase of the cardiac cycle is characterized by the closure of Ca channels and outward K flow?

<p>Phase 3 (B)</p> Signup and view all the answers

Which type of channel blockers belong to Class IV antiarrhythmic drugs?

<p>Ca2+ channel blockers (B)</p> Signup and view all the answers

What is the consequence of blood pooling in the venous system without adequate return to the heart?

<p>Fluid accumulation in tissues (A)</p> Signup and view all the answers

How do nitrovasodilators primarily cause vasodilation?

<p>By inhibiting PDEV and increasing dGMP levels (D)</p> Signup and view all the answers

What side effect can occur from overuse of nitroglycerin?

<p>Priapism (B)</p> Signup and view all the answers

Which of the following is a common nitrovasodilator used for angina and stroke?

<p>Isosorbide Dinitrate (D)</p> Signup and view all the answers

What is the 'Monday Syndrome' associated with the overuse of nitroglycerin?

<p>Triggering or exacerbation of migraine headaches (C)</p> Signup and view all the answers

What is the primary pharmacological action of nitroglycerin in terms of vasodilation?

<p>Inhibiting PDEV activity (C)</p> Signup and view all the answers

What is the function of carbonic anhydrase in the proximal convoluted tubule?

<p>To catalyze the interconversion of carbon dioxide and water to bicarbonate and protons (D)</p> Signup and view all the answers

What is the consequence of inhibiting carbonic anhydrase in the proximal convoluted tubule?

<p>Increased excretion of Na+, K+, and HCO3 (B)</p> Signup and view all the answers

Which group is considered essential for the diuretic activity of carbonic anhydrase inhibitors?

<p>A free sulfamoyl nitrogen attached to an aromatic system (D)</p> Signup and view all the answers

Which part of the nephron is targeted by loop diuretics according to the text?

<p>Thick ascending loop of Henle (C)</p> Signup and view all the answers

What is the role of the SO2NH2 group at position 5 according to the text?

<p>It is essential for diuretic activity in loop diuretics (C)</p> Signup and view all the answers

Why does inhibiting carbonic anhydrase lead to increased excretion of Na+, K+, and HCO3?

<p>Because Na+ absorption is disrupted as water follows Na+ (A)</p> Signup and view all the answers

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