Diuretic Medications Overview
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Questions and Answers

Which diuretic inhibits the action of aldosterone and leads to the excretion of Na and H?

  • Mercaptomerin
  • Dextrose
  • Caffeine
  • Amiloride (correct)
  • What is the potential drawback of arteriolar vasodilation mentioned in the text?

  • Pooling of blood in the veins (correct)
  • Increased blood pressure
  • Veins constricting excessively
  • Decreased blood flow to organs
  • Which aquaporins facilitate the movement of water from the tubule lumen into the bloodstream?

  • Aquaporin-4
  • Aquaporin-1
  • Aquaporin-3
  • Aquaporin-2 (correct)
  • Which compound resembles progesterone and inhibits aldosterone while promoting potassium retention?

    <p>Spironolactone</p> Signup and view all the answers

    Which of the following is classified as an osmotic diuretic?

    <p>Mannose</p> Signup and view all the answers

    What is the main effect of imidazoline-1 receptor agonists like Clonidine?

    <p>Antihypertensive effect</p> Signup and view all the answers

    What is the main effect of high ceiling diuretics on the body?

    <p>Cause hypokalemia</p> Signup and view all the answers

    Which part of the body is affected by ototoxicity caused by high ceiling diuretics?

    <p>Cochlea</p> Signup and view all the answers

    Which type of diuretic is considered obsolete due to its potential to rupture the ear?

    <p>Phenoxyacetic acid derivatives</p> Signup and view all the answers

    What is the typical onset of action for high ceiling diuretics?

    <p>30 minutes</p> Signup and view all the answers

    Which ion reabsorption is inhibited by thiazide diuretics?

    <p>Na+, K+, Mg2+, Ca2+, and Cl-</p> Signup and view all the answers

    How can ineffective pumping by the right heart lead to fluid leakage into lung tissues?

    <p>By causing increased blood pressure in the blood vessels of the lungs</p> Signup and view all the answers

    Which part of the ECG records the ventricular depolarization?

    <p>QRS complex</p> Signup and view all the answers

    During which phase of the cardiac cycle does rapid depolarization occur?

    <p>Phase 0</p> Signup and view all the answers

    Which class of antiarrhythmic drugs includes Amiodarone?

    <p>Class III (K+ channel blockers)</p> Signup and view all the answers

    What does the T wave in the ECG represent?

    <p>Ventricular repolarization</p> Signup and view all the answers

    Which phase of the cardiac cycle is characterized by the closure of Ca channels and outward K flow?

    <p>Phase 3</p> Signup and view all the answers

    Which type of channel blockers belong to Class IV antiarrhythmic drugs?

    <p>Ca2+ channel blockers</p> Signup and view all the answers

    What is the consequence of blood pooling in the venous system without adequate return to the heart?

    <p>Fluid accumulation in tissues</p> Signup and view all the answers

    How do nitrovasodilators primarily cause vasodilation?

    <p>By inhibiting PDEV and increasing dGMP levels</p> Signup and view all the answers

    What side effect can occur from overuse of nitroglycerin?

    <p>Priapism</p> Signup and view all the answers

    Which of the following is a common nitrovasodilator used for angina and stroke?

    <p>Isosorbide Dinitrate</p> Signup and view all the answers

    What is the 'Monday Syndrome' associated with the overuse of nitroglycerin?

    <p>Triggering or exacerbation of migraine headaches</p> Signup and view all the answers

    What is the primary pharmacological action of nitroglycerin in terms of vasodilation?

    <p>Inhibiting PDEV activity</p> Signup and view all the answers

    What is the function of carbonic anhydrase in the proximal convoluted tubule?

    <p>To catalyze the interconversion of carbon dioxide and water to bicarbonate and protons</p> Signup and view all the answers

    What is the consequence of inhibiting carbonic anhydrase in the proximal convoluted tubule?

    <p>Increased excretion of Na+, K+, and HCO3</p> Signup and view all the answers

    Which group is considered essential for the diuretic activity of carbonic anhydrase inhibitors?

    <p>A free sulfamoyl nitrogen attached to an aromatic system</p> Signup and view all the answers

    Which part of the nephron is targeted by loop diuretics according to the text?

    <p>Thick ascending loop of Henle</p> Signup and view all the answers

    What is the role of the SO2NH2 group at position 5 according to the text?

    <p>It is essential for diuretic activity in loop diuretics</p> Signup and view all the answers

    Why does inhibiting carbonic anhydrase lead to increased excretion of Na+, K+, and HCO3?

    <p>Because Na+ absorption is disrupted as water follows Na+</p> Signup and view all the answers

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