5 Questions
What is a disperse system?
A system where one substance is distributed in discrete units throughout a second substance
What can the phases in a disperse system exist as?
Solid, liquid, or gaseous
What is the internal phase in a pharmaceutical suspension?
Insoluble solid particles
What are the reasons for the formulation of a pharmaceutical suspension?
Pharmacokinetic modification, solubility and stability, liquid vs. solid dosage form, palatability
What is the range of size for insoluble solid particles in a pharmaceutical suspension?
0.5 to 5 microns
Study Notes
Disperse Systems
- A disperse system is a mixture in which one substance is dispersed in another substance, often in different phases.
Phases in Disperse Systems
- The phases in a disperse system can exist as: • Solid-in-liquid (suspension) • Liquid-in-liquid (emulsion) • Gas-in-liquid (foam) • Solid-in-gas (aerosol)
Pharmaceutical Suspensions
- In a pharmaceutical suspension, the internal phase is the insoluble solid particles of the active pharmaceutical ingredient (API).
Reasons for Formulation of Pharmaceutical Suspensions
- Pharmaceutical suspensions are formulated: • To improve bioavailability of insoluble drugs • To mask unpleasant taste or odor of the API • To provide a more efficient method of administration • To reduce the frequency of dosing
Particle Size in Pharmaceutical Suspensions
- The range of size for insoluble solid particles in a pharmaceutical suspension is typically between 0.1 μm and 100 μm.
Test your knowledge of disperse systems with this quiz. Explore the characteristics of dispersed and continuous phases, as well as the different states in which they can exist. Learn about suspensions and their composition.
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