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Questions and Answers
What is a disperse system?
What is a disperse system?
- A system where one substance is dissolved in a second substance
- A system where two substances are completely mixed together
- A system where one substance is distributed in discrete units throughout a second substance (correct)
- A system where two substances are separated by a barrier
What can the phases in a disperse system exist as?
What can the phases in a disperse system exist as?
- Solid only
- Solid, liquid, or gaseous (correct)
- Liquid only
- Gaseous only
What is the internal phase in a pharmaceutical suspension?
What is the internal phase in a pharmaceutical suspension?
- Dissolved solid particles
- Gaseous particles
- Insoluble solid particles (correct)
- Soluble liquid particles
What are the reasons for the formulation of a pharmaceutical suspension?
What are the reasons for the formulation of a pharmaceutical suspension?
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What is the range of size for insoluble solid particles in a pharmaceutical suspension?
What is the range of size for insoluble solid particles in a pharmaceutical suspension?
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Study Notes
Disperse Systems
- A disperse system is a mixture in which one substance is dispersed in another substance, often in different phases.
Phases in Disperse Systems
- The phases in a disperse system can exist as: • Solid-in-liquid (suspension) • Liquid-in-liquid (emulsion) • Gas-in-liquid (foam) • Solid-in-gas (aerosol)
Pharmaceutical Suspensions
- In a pharmaceutical suspension, the internal phase is the insoluble solid particles of the active pharmaceutical ingredient (API).
Reasons for Formulation of Pharmaceutical Suspensions
- Pharmaceutical suspensions are formulated: • To improve bioavailability of insoluble drugs • To mask unpleasant taste or odor of the API • To provide a more efficient method of administration • To reduce the frequency of dosing
Particle Size in Pharmaceutical Suspensions
- The range of size for insoluble solid particles in a pharmaceutical suspension is typically between 0.1 μm and 100 μm.
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