Diseases Linked to Organelle Dysfunction

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Questions and Answers

Match the following diseases with their associated organelles:

Tay-Sachs Disease = Lysosomes McArdle Disease = Mitochondria Kearns-Sayre Disease = Mitochondria Amyotrophic Lateral Sclerosis = Intermediate filaments

Match the following organelles with their primary functions in disease context:

Lysosomes = Contain hydrolytic enzymes Mitochondria = Energy production Intermediate filaments = Structural support Hydrolytic enzymes = Degradation of biomolecules

Match the following diseases with their descriptions:

Tay-Sachs Disease = Associated with lysosomal dysfunction McArdle Disease = Mitochondrial myopathy Kearns-Sayre Disease = Mitochondrial disorder affecting muscles and eyes Amyotrophic Lateral Sclerosis = Degeneration of motor neurons

Match the following disease categories with their specific diseases:

<p>Lysosomal Storage Disorders = Tay-Sachs Disease Mitochondrial Disorders = McArdle Disease Neuromuscular Disorders = Kearns-Sayre Disease Motor Neuron Diseases = Amyotrophic Lateral Sclerosis</p> Signup and view all the answers

Match the following diseases with their symptoms or complications:

<p>Tay-Sachs Disease = Neurodegeneration leading to early mortality McArdle Disease = Exercise intolerance due to lack of energy Kearns-Sayre Disease = Heart block and eye problems Amyotrophic Lateral Sclerosis = Muscle weakness and atrophy</p> Signup and view all the answers

Flashcards

Tay-Sachs disease

A genetic disorder caused by the accumulation of a fatty substance called ganglioside GM2 in the brain due to a deficiency of the enzyme hexosaminidase A, which is involved in lysosome function.

McArdle disease

A rare genetic disorder characterized by the accumulation of glycogen in muscles due to a deficiency of the enzyme glycogen phosphorylase, which is involved in breaking down glycogen in mitochondria.

Kearns-Sayre Disease

A rare genetic disorder that affects the mitochondria, leading to a variety of symptoms including heart problems, vision loss, and muscle weakness.

Amyotrophic lateral sclerosis (ALS)

A neurodegenerative disease that affects motor neurons, leading to progressive muscle weakness, paralysis, and eventually death.

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Neurofilaments

Intermediate filaments that help to maintain the shape and stability of neurons.

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Study Notes

Diseases Associated with Organelle Dysfunction

Tay-Sachs Disease: Linked to lysosomes, which are membrane-bound sacs containing enzymes.
McArdle Disease: Stems from mitochondrial malfunction.
Kearns-Sayre Disease: Affects mitochondria.
Amyotrophic Lateral Sclerosis (ALS): Involves a problem with intermediate filaments, specifically neurofilaments.