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Questions and Answers
What is the focus of the article?
What is the focus of the article?
- Direct organocatalytic aldol reactions (correct)
- Prebiotic route to sugars
- Stereoselective construction
- Enzyme mechanism in nature
What is the significance of the aldol reaction in nature?
What is the significance of the aldol reaction in nature?
- It only occurs in aqueous media
- It is a key carbon–carbon bond-forming reaction (correct)
- It produces absolute stereocontrol
- It is exclusively catalyzed by enzymes
What do Class I aldolases utilize to catalyze the reaction in nature?
What do Class I aldolases utilize to catalyze the reaction in nature?
- Organocatalysts
- Zinc cofactor
- Enamine mechanism (correct)
- Acidic media
Why have the features of nature's aldol reaction been difficult to mimic chemically?
Why have the features of nature's aldol reaction been difficult to mimic chemically?
What does the article suggest about organocatalytic cross-aldol reactions?
What does the article suggest about organocatalytic cross-aldol reactions?
What is the potential significance of the organocatalytic cross-aldol reactions?
What is the potential significance of the organocatalytic cross-aldol reactions?
What is the main focus of the passage?
What is the main focus of the passage?
What was found to be beneficial as an additive to PBS-buffer in accelerating the aldol reactions?
What was found to be beneficial as an additive to PBS-buffer in accelerating the aldol reactions?
What did the addition of SDS to the mixture do to the uncatalyzed reaction?
What did the addition of SDS to the mixture do to the uncatalyzed reaction?
What did the proline-catalyzed reaction in PBS/SDS completely inhibit by addition of sodium cyanide?
What did the proline-catalyzed reaction in PBS/SDS completely inhibit by addition of sodium cyanide?
What was effective for 2-butanone affording aldol adducts 3 and 4 in good yield with modest regio- and diastereoselectivity?
What was effective for 2-butanone affording aldol adducts 3 and 4 in good yield with modest regio- and diastereoselectivity?
What was not a donor under L-proline catalysis?
What was not a donor under L-proline catalysis?
What did the study of amines, amino acids, and small peptides as biomimetic catalysts long intrigue?
What did the study of amines, amino acids, and small peptides as biomimetic catalysts long intrigue?
What has been reported capable of catalyzing intermolecular aldol reactions with acetone as the donor under physiological conditions?
What has been reported capable of catalyzing intermolecular aldol reactions with acetone as the donor under physiological conditions?
What did the synthesis of polyhydroxylated products under environmentally benign reaction conditions provide for?
What did the synthesis of polyhydroxylated products under environmentally benign reaction conditions provide for?
What was the focus of the study aside from synthesizing polyhydroxylated products under environmentally benign conditions?
What was the focus of the study aside from synthesizing polyhydroxylated products under environmentally benign conditions?
What is the focus of the study mentioned in the passage?
What is the focus of the study mentioned in the passage?
What is typically used by Class I aldolases to catalyze the aldol reaction in nature?
What is typically used by Class I aldolases to catalyze the aldol reaction in nature?
What has been particularly difficult to mimic chemically, as mentioned in the passage?
What has been particularly difficult to mimic chemically, as mentioned in the passage?
What did the organocatalytic cross-aldol reactions in aqueous media provide a direct route to?
What did the organocatalytic cross-aldol reactions in aqueous media provide a direct route to?
What was found to be beneficial as an additive to PBS-buffer in accelerating the aldol reactions?
What was found to be beneficial as an additive to PBS-buffer in accelerating the aldol reactions?
What was found to be beneficial as an additive to PBS-buffer in accelerating the aldol reactions?
What was found to be beneficial as an additive to PBS-buffer in accelerating the aldol reactions?
What did the proline-catalyzed reaction in PBS/SDS completely inhibit by addition of sodium cyanide?
What did the proline-catalyzed reaction in PBS/SDS completely inhibit by addition of sodium cyanide?
What was not a donor under L-proline catalysis?
What was not a donor under L-proline catalysis?
Why have synthetically useful aldol reactions in aqueous media been rare?
Why have synthetically useful aldol reactions in aqueous media been rare?
What did the synthesis of polyhydroxylated products under environmentally benign reaction conditions provide for?
What did the synthesis of polyhydroxylated products under environmentally benign reaction conditions provide for?
What was effective for 2-butanone affording aldol adducts 3 and 4 in good yield with modest regio- and diastereoselectivity?
What was effective for 2-butanone affording aldol adducts 3 and 4 in good yield with modest regio- and diastereoselectivity?
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