Digestive System: Anatomy and Function
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Which of the following characteristics accurately describe the epithelium found in the stomach?

  • Stratified squamous epithelium with goblet cells.
  • Pseudostratified ciliated columnar epithelium.
  • Simple columnar epithelium specialized for absorption.
  • Simple columnar epithelium with mucous-secreting cells. (correct)

Brunner's glands are a distinctive feature of which gastrointestinal structure, and in which layer are they primarily located?

  • Duodenum; submucosa (correct)
  • Appendix; muscularis externa
  • Esophagus; adventitia
  • Stomach; mucosa

What is the primary function of the gastric pits found in the stomach's mucosa?

  • To house glands that secrete gastric juices. (correct)
  • To increase the surface area for nutrient absorption.
  • To produce bile for fat emulsification.
  • To facilitate peristaltic movements.

Villi and intestinal crypts are prominent mucosal structures in the duodenum. What is the main purpose of villi?

<p>Increase surface area for absorption. (A)</p> Signup and view all the answers

Pyloric glands are found within the mucosa of a specific gastrointestinal organ. Which of the following organs contains pyloric glands?

<p>Stomach (B)</p> Signup and view all the answers

Which of the following characteristics correctly differentiate serosa from adventitia in the GI tract?

<p>Serosa is covered by mesothelium, whereas adventitia lacks a mesothelium layer. (C)</p> Signup and view all the answers

A pathologist is examining a tissue sample from the tongue and notes numerous projections on the dorsal epithelium. These projections are small, cone-shaped, and heavily keratinized. Which type of papillae are they MOST likely observing?

<p>Filiform papillae (C)</p> Signup and view all the answers

During a physical examination, a doctor observes a patient's tongue and notices several mushroom-shaped structures, primarily on the anterior region. These structures appear reddish due to underlying blood vessels. Which specific structures are MOST likely being observed?

<p>Fungiform papillae (A)</p> Signup and view all the answers

A surgeon is operating on a section of the GI tract that is freely floating within the peritoneal cavity. Which type of tissue covering is MOST likely present on the outer surface of this section?

<p>Serosa, covered by mesothelium (B)</p> Signup and view all the answers

Which of the following best describes the PRIMARY function of saliva within the oral cavity regarding the initial stages of digestion?

<p>To provide lubrication for swallowing and begin carbohydrate digestion (D)</p> Signup and view all the answers

A tissue sample taken from the outer layer of a GI tract segment shows no distinct mesothelium and appears directly connected to the abdominal wall. This sample MOST likely came from a region covered by which structure?

<p>Adventitia (C)</p> Signup and view all the answers

What is a key structural difference between filiform and fungiform papillae that relates to their function?

<p>Filiform papillae are heavily keratinized, providing texture, while fungiform papillae have a thinner epithelial covering, often containing taste buds. (D)</p> Signup and view all the answers

If a surgeon needs to mobilize a segment of the small intestine during a procedure, which tissue layer MUST be carefully handled to minimize friction and potential damage to surrounding structures?

<p>The serosal layer, responsible for secreting fluid to reduce friction (D)</p> Signup and view all the answers

Which gastric cell type is primarily responsible for the production of hydrochloric acid (HCl) in the stomach?

<p>Parietal/Oxyntic Cells (B)</p> Signup and view all the answers

Why is intrinsic factor, secreted by parietal cells, essential for normal physiological function?

<p>It facilitates the absorption of Vitamin B12 in the terminal ileum. (B)</p> Signup and view all the answers

How do surface mucous cells protect the stomach lining from damage?

<p>By producing a thick layer of mucus and secreting bicarbonate ions. (B)</p> Signup and view all the answers

If a patient undergoes a total gastrectomy (removal of the stomach), which of the following nutritional deficiencies is most likely to develop long-term?

<p>Vitamin B12 Deficiency (B)</p> Signup and view all the answers

What is the primary function of the pyloric sphincter, formed by the thickening of the middle circular layer of the muscularis externa?

<p>To regulate the release of chyme into the duodenum. (D)</p> Signup and view all the answers

Which layer of the gastric wall contains dense connective tissue, lymph vessels, and a network of blood vessels essential for nutrient absorption?

<p>Submucosa (C)</p> Signup and view all the answers

The myenteric (Auerbach's) plexus, found between the muscle layers of the muscularis externa, is primarily responsible for what function?

<p>Propelling food through the digestive tract. (B)</p> Signup and view all the answers

Pepsinogen is secreted by chief cells and is converted into pepsin in the stomach. What is the importance of secreting pepsinogen in an inactive form?

<p>To prevent auto-digestion of the stomach lining by pepsin. (C)</p> Signup and view all the answers

What is the role of soluble mucus, manufactured by neck mucous cells, in the stomach?

<p>Lubricating the alimentary canal and becoming part of chyme. (C)</p> Signup and view all the answers

Which hormone is produced by the 'I' cell and what is its primary function?

<p>Cholecystokinin; stimulates release of pancreatic enzymes (C)</p> Signup and view all the answers

Which layer of the muscularis externa is NOT present in all areas of the stomach?

<p>Inner Oblique (D)</p> Signup and view all the answers

If a patient's gastric motility is significantly reduced, which of the following hormones might be deficient?

<p>Gastrin (B)</p> Signup and view all the answers

Which cell type, when stimulated, leads to an increase in stomach acid production?

<p>ECL cell (A)</p> Signup and view all the answers

A drug that inhibits the action of which hormone would likely be prescribed to alleviate symptoms of excessive intestinal peristalsis?

<p>Motilin (C)</p> Signup and view all the answers

A patient is experiencing difficulty with fat digestion due to impaired gallbladder contraction. Which hormone level is most likely affected?

<p>Cholecystokinin (B)</p> Signup and view all the answers

If a researcher aims to study a substance that decreases intestinal peristalsis, which hormone should they focus on?

<p>Neurotensin (B)</p> Signup and view all the answers

Which hormone directly inhibits the secretion of hydrochloric acid (HCl)?

<p>Gastric inhibitory peptide (D)</p> Signup and view all the answers

Which hormone stimulates the release of pancreatic buffer?

<p>Secretin (A)</p> Signup and view all the answers

Which of the following pairs correctly matches a hormone to its primary effect on blood glucose levels?

<p>Glucagon and increase blood glucose (C)</p> Signup and view all the answers

If chief cells aren't releasing enzymes effectively, supplementing which hormone might help?

<p>Pancreatic polypeptide (D)</p> Signup and view all the answers

Which structural feature is responsible for the characteristic sacculated appearance (haustra) of the colon?

<p>The presence of the taeniae coli, which are three longitudinal bands of muscle. (C)</p> Signup and view all the answers

In the large intestine, what is the primary function of the abundant goblet cells found within the epithelium?

<p>Producing mucus to lubricate the passage of feces. (A)</p> Signup and view all the answers

If a patient has damage to the Auerbach/Myenteric nerve plexus in their large intestine, which function would be most directly affected?

<p>Contractions of the muscularis externa for peristalsis. (B)</p> Signup and view all the answers

How does the absorptive function of the large intestine differ from that of the small intestine?

<p>The large intestine primarily absorbs water, whereas the small intestine primarily absorbs nutrients. (A)</p> Signup and view all the answers

Which histological feature is characteristic of the appendix?

<p>Numerous lymphoid nodules in the mucosa and submucosa. (A)</p> Signup and view all the answers

What is the significance of germinal centers within the lymphoid nodules of the appendix?

<p>They are active sites of B-lymphocyte production. (A)</p> Signup and view all the answers

How do primary and secondary follicles differ within the lymphoid tissue of the appendix?

<p>Primary follicles are homogenous, while secondary follicles have pale, active germinal centers. (C)</p> Signup and view all the answers

A surgeon is operating on a patient and needs to identify the transverse colon. Which characteristic of the transverse colon would assist in its identification?

<p>It is covered by serosa and is intraperitoneal. (D)</p> Signup and view all the answers

What is a key feature that distinguishes the large intestine from the small intestine at the macroscopic level?

<p>The presence of taeniae coli and haustra in the large intestine. (D)</p> Signup and view all the answers

Which of the following best describes the muscularis externa of the large intestine?

<p>Two complete layers (inner circular and outer longitudinal) plus the taeniae coli. (A)</p> Signup and view all the answers

What is the primary function of lacteals found within the lamina propria of the small intestine?

<p>Absorbing lipids and transporting them to the cisterna chyli via the thoracic ducts. (A)</p> Signup and view all the answers

The plicae circulares, villi, and microvilli collectively function to:

<p>Increase the surface area available for nutrient absorption in the small intestine. (C)</p> Signup and view all the answers

The muscularis mucosae, composed of smooth muscle fibers, extends into the core of individual villi. What is its primary role?

<p>To facilitate movement of the villi, increasing contact with digested food products. (C)</p> Signup and view all the answers

In cases of acute gastroenteritis caused by a virus attacking microvilli, which of the following is the most likely consequence?

<p>Severe malabsorption due to the reduced surface area for nutrient uptake. (B)</p> Signup and view all the answers

If the flow of nutrients from the enterocytes to the liver is blocked, what would happen?

<p>Nutrient absorption is impaired as the nutrients cannot reach the circulation for distribution. (D)</p> Signup and view all the answers

Which component of the lamina propria is specifically responsible for absorbing lipids?

<p>Lacteals (D)</p> Signup and view all the answers

What is the primary function of the Crypts of Lieberkuhn?

<p>Openings for tubular glands (D)</p> Signup and view all the answers

Why does lactose intolerance often result in diarrhea and flatulence?

<p>Unabsorbed lactose attracts water into the large intestine, promoting bacterial fermentation and gas production. (D)</p> Signup and view all the answers

What is the function of Plicae circulares?

<p>Enhance nutrient absorption (B)</p> Signup and view all the answers

What is the role of lymphoid follicles in the lamina propria?

<p>Initiating immune responses. (D)</p> Signup and view all the answers

Flashcards

Filiform papillae

Projections on the tongue's dorsal epithelium, primarily for texture.

Fungiform papillae

Mushroom-shaped papillae, involved in taste sensation.

Serosa

Outer layer covering intraperitoneal segments of the GI tract; secretes fluid.

Adventitia

Connective tissue layer covering retroperitoneal segments of the GI tract.

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Mastication

Process of chewing food to break it down for swallowing.

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Tongue

Muscular organ in the oral cavity that manipulates ingested material.

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Simple squamous epithelium

Thin layer of flat cells, found in serosa and lining of cavities.

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Taste buds

Sensory structures located on tongue surfaces, involved in taste perception.

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Surface Mucous Cells

Mucosal cells producing mucus and bicarbonate to protect the stomach lining.

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Neck Mucous Cells

Cells found between parietal cells that manufacture soluble mucus for chyme.

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Parietal Cells

Cells that secrete gastric acid and intrinsic factor, crucial for digestion and B12 absorption.

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Intrinsic Factor

A glycoprotein secreted by parietal cells that binds Vitamin B12 for absorption.

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Chief Cells

Cells that secrete pepsinogen, which is converted to pepsin for protein digestion.

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Gastric Acid

Hydrochloric acid produced by parietal cells that maintains stomach acidity for digestion.

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Muscularis Externa

The muscular layer of the stomach composed of three muscle layers: inner oblique, middle circular, and outer longitudinal.

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Pyloric Sphincter

Thickened part of the middle circular muscle at the pylorus that controls flow to the duodenum.

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Submucosa

Layer beneath the mucosa containing connective tissue, blood vessels, and lymphatics important for nutrient absorption.

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Myenteric Nerve Plexus

Nerve network located between the muscle layers that controls gastrointestinal motility.

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Simple columnar epithelium

Single layer of tall, column-like cells, lining the stomach.

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Gastric pits

Invaginations in the stomach mucosa that house gastric glands.

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Pyloric glands

Glands located in the pyloric region of the stomach that secrete mucus and gastric juices.

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Brunner’s glands

Glands in the duodenum that secrete an alkaline fluid to neutralize stomach acid.

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Villi

Finger-like projections in the intestinal mucosa to increase surface area for absorption.

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Plicae Circulares

Permanent folds of the mucosa that increase surface area in the small intestine.

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Lamina Propria

The connective tissue layer of the mucosa containing blood vessels, nerves, and lymphatics.

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Microvilli

Microscopic projections on enterocytes that further increase the surface area for absorption.

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Enterocytes

Absorptive cells in the intestinal epithelium equipped with microvilli.

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Crypts of Lieberkuhn

Indentations in the mucosa that serve as openings for intestinal glands.

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Lacteals

Lymphatic vessels in the villi that absorb lipids.

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Muscularis Mucosae

Smooth muscle layer in the mucosa that aids in moving villi for better contact with food.

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Submucosal Plexus

Nerve network in the submucosa that helps regulate gut motility.

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Glycocalyx

A carbohydrate-rich zone on the microvilli, aiding in nutrient absorption and protection.

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Taenia coli

Three longitudinal bands of smooth muscle in the colon.

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Haustra

Shallow sacculations formed by taenia coli in the colon.

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Auerbach/Myenteric Plexus

Nerve plexus located between muscle layers, innervating muscularis externa.

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Mucosa of the large intestine

Inner layer containing simple columnar epithelium rich in goblet cells.

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Goblet cells

Cells in the large intestine mucosa producing mucus for lubrication.

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Appendix

Slender tube from the cecum with immunologic functions, not vestigial.

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MALT (Mucosa-associated lymphoid tissue)

Tissue containing lymphoid follicles, important for immune response in mucosa.

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Primary and Secondary follicles

Lymphoid nodules in the appendix, with germinal centers for B-lymphocyte production.

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Glucagon

Hormone produced in the stomach and small intestine that elevates blood glucose levels.

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Somatostatin

Hormone secreted by DNES cells in the stomach and intestines that inhibits hormone release.

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Serotonin

Produced by enterochromaffin cells, it increases peristaltic movement in the GI tract.

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Histamine

Hormone from enterochromaffin-like cells that stimulates HCl secretion in the stomach.

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Gastrin

Hormone from gastrin-producing cells that stimulates HCl secretion and gastric motility.

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Glicentin

Hormone produced in the stomach and intestines that elevates blood glucose.

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Cholecystokinin (CCK)

Hormone secreted in the small intestine that stimulates pancreatic enzyme release and gallbladder contraction.

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Gastric Inhibitory Peptide (GIP)

Hormone from the small intestine that inhibits HCl secretion.

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Motilin

Hormone that increases intestinal peristalsis, produced in the small intestine.

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Vasoactive Intestinal Peptide (VIP)

Hormone in the stomach and intestines that increases peristalsis and stimulates water and ion elimination.

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Study Notes

Digestive System Overview

  • The digestive system is a long tube with specialized segments for processing food
  • Each segment has specific functions and corresponding tissue structures that differ based on function
  • Digestion occurs through physical and chemical processes
  • The process moves from mouth to esophagus, stomach, small intestine, large intestine, rectum, and anal canal

Major Layers of the Digestive Tract

  • Digestive tracts have four major layers arranged from the lumen outward: mucosa, submucosa, muscularis, serosa/adventitia
  • Mucosa: inner layer, typically simple columnar or stratified squamous epithelium, containing lamina propria (loose connective tissue with blood vessels and lymphatics) and muscularis mucosae (smooth muscle)
  • Submucosa: dense connective tissue with larger blood and lymphatic vessels, nerves, and glands
  • Muscularis: smooth muscle organized in layers (inner circular, outer longitudinal) for mixing and propelling food
  • Serosa/adventitia: outermost layer, loose connective tissue rich in blood vessels and lymphatics for protection and reduced friction, lined with mesothelium in intraperitoneal segments

Upper Digestive Tract Details

  • Oral Cavity: Ingests, chews, and starts carbohydrate breakdown with salivary amylase; also lubricates and cleans
  • Esophagus: Transporting food to stomach via peristalsis, upper portion is skeletal, and lower portion is smooth muscle
  • Stomach: Storing and mixing food with gastric juices to form chyme; begins protein breakdown and continues carbohydrate breakdown

Cells of the Gastric Glands

  • Surface mucous cells: Secrete mucus to protect the stomach lining from acid
  • Neck mucous cells: Secrete soluble mucus
  • Parietal cells: Produce hydrochloric acid (HCl) and intrinsic factor
  • Chief/Peptic cells: Produce pepsinogen (converts to pepsin) for protein digestion; prevent autodigestion of stomach
  • Stem cells: Constantly divide and differentiate to replace other cell types

Lower Digestive Tract Details

  • Small Intestine: Completes digestion and absorbs nutrients, has three regions (duodenum, jejunum, ileum). Main absorptive cells are called enterocytes which have microvilli for maximum surface area
  • Large Intestine: Absorbs water, electrolytes, and vitamins and stores undigested material prior to elimination as feces
  • Appendix: Part of the large intestine, containing large amounts of lymphoid tissue; important for immune response

Transition Zones

  • Esophago-gastric Junction: Transition between stratified squamous epithelium of esophagus and simple columnar epithelium of stomach
  • Gastro-duodenal Junction: Transition between simple columnar epithelium of stomach and duodenum of small intestine
  • Recto-anal Junction: Transition between simple columnar epithelium of rectum and stratified squamous epithelium of anus

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Description

Explore the digestive system's structure and function. Learn about the major tissue layers, including the mucosa, submucosa, and muscularis. Understand how these layers contribute to the digestion process from the mouth to the anal canal.

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