Differential Diagnoses for T-cell Lymphomas Quiz

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What is the most common type of cutaneous T cell lymphoma?

Clonal CD4+ T cells (correct)

CD8+ T cells

CD45+ cells

TTF1+ cells

Which type of tumor cells are found in Sézary syndrome?

Hodgkin lymphoma cells

Neoplastic T cells with cerebriform nuclei (correct)

Monotonous round tumor cells

Metastatic small cell carcinoma

Which stage of Mycosis Fungoides is characterized by thickened plaques that may resemble psoriasis?

Plaque (correct)

Sézary syndrome

Tumoral

Patch

Which microscopic feature is associated with the patch stage of Mycosis Fungoides?

Clustered in epidermis Signup and view all the answers

What is the differential diagnosis for metastatic small cell carcinoma if it is from the lung?

TTF1+ Signup and view all the answers

What characterizes Sézary syndrome?

Erythroderma and neoplastic T cells w cerebriform nuclei Signup and view all the answers

Which tumor cells are positive for CD4 and negative for CD8 in Mycosis Fungoides?

Neoplastic T cells w cerebriform nuclei Signup and view all the answers

What are the microscopic features of actinic keratosis?

Parakeratosis and dermal elastosis Signup and view all the answers

Which type of UV radiation is absorbed by the epidermis and considered the most carcinogenic?

UV-B Signup and view all the answers

What gene mutation is associated with the pathogenesis of basal cell carcinoma?

p53 Signup and view all the answers

What is the most common type of basal cell carcinoma to be seen in sun-exposed skin?

Superficial basal cell carcinoma Signup and view all the answers

Which treatment for basal cell carcinoma is not always needed?

Chemotherapy Signup and view all the answers

What are hedgehog proteins involved in?

Cell proliferation and differentiation Signup and view all the answers

What are the risk factors for basal cell carcinoma?

UV exposure, gene mutations, arsenic exposure Signup and view all the answers

What causes the small rough spots seen in actinic keratosis?

Cutaneous horn Signup and view all the answers

Which of the following tumors is associated with nevoid basal cell carcinoma syndrome?

Basal cell carcinomas in the skin Signup and view all the answers

What is a common risk factor for squamous cell carcinoma (SCC) mentioned in the text?

HPV 5/8 infection Signup and view all the answers

Which of the following tumor types express neuroendocrine markers such as CD56 and chromogranin?

Merkel cell carcinoma Signup and view all the answers

Which type of squamous cell carcinoma is characterized by loss of intercellular connection (Acantholysis)?

Conventional type Signup and view all the answers

Which tumor type is graded according to the degree of differentiation and may present with ulceration and hemorrhage?

Squamous cell carcinomas Signup and view all the answers

What is a microscopic feature of Merkel cell carcinoma?

Monotonous round tumor cells Signup and view all the answers

Which of the following tumors is NOT associated with nevoid basal cell carcinoma syndrome?

Pancreatic cancer Signup and view all the answers

Which infection is often a risk factor for squamous cell carcinoma?

Human papillomavirus (HPV) Signup and view all the answers