Podcast
Questions and Answers
Which condition is characterized by the production of significant fetal hemoglobin (hemoglobin F) well into adulthood?
Which condition is characterized by the production of significant fetal hemoglobin (hemoglobin F) well into adulthood?
- Hereditary persistence of fetal hemoglobin (HPFH) (correct)
- Thalassemia
- Sickle cell anemia
- Hemoglobin Gun Hill
What is the result of a point mutation in Hbß, leading to a change from Glu to Val at amino acid 6?
What is the result of a point mutation in Hbß, leading to a change from Glu to Val at amino acid 6?
- Thalassemia
- Hereditary persistence of fetal hemoglobin (HPFH)
- Hemoglobin Gun Hill
- Sickle cell anemia (correct)
Which condition is associated with the deletion of five amino acids in the β-chains of the abnormal protein?
Which condition is associated with the deletion of five amino acids in the β-chains of the abnormal protein?
- Sickle cell anemia
- Hb Barts
- Thalassemia
- Hemoglobin Gun Hill (correct)
What is the characteristic feature of Hb Barts and HbH in alpha-thalassemia?
What is the characteristic feature of Hb Barts and HbH in alpha-thalassemia?
In uncontrolled diabetes, what can increase more than twice normal, leading to the generation of more HbA1c than normal?
In uncontrolled diabetes, what can increase more than twice normal, leading to the generation of more HbA1c than normal?
What is the result of a point mutation in Hbß, leading to a change from Glu to Val at amino acid 6?
What is the result of a point mutation in Hbß, leading to a change from Glu to Val at amino acid 6?
What happens in α thalassemia when one of the 4 gene copies are not expressed?
What happens in α thalassemia when one of the 4 gene copies are not expressed?
What are the subunits that form tetramers in beta thalassemia?
What are the subunits that form tetramers in beta thalassemia?
What is associated with a point mutation in Hbß that leads to the formation of Hb C or Hb E?
What is associated with a point mutation in Hbß that leads to the formation of Hb C or Hb E?
What results from a mutation or incorrect splicing in beta thalassemia?
What results from a mutation or incorrect splicing in beta thalassemia?
