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Didanosine Pharmacology Quiz

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Questions and Answers

What is the drug class of Didanosine?

Non-nucleoside RTI

Integrase Inhibitor

Nucleoside RTI (adenosine analogue) (correct)

Protease Inhibitor

What are the brand names and abbreviations for Didanosine?

Videx, Videx EC, ddI

What are the major adverse drug reactions (ADRs) of Didanosine?

Diarrhea, Peripheral neuropathy, Pancreatitis

Didanosine has major interactions with other drugs.

<p>False</p> Signup and view all the answers

What are the dosing considerations for Didanosine?

<p>QD dosing possible, take on empty stomach, renal adjustment recommended</p> Signup and view all the answers

Study Notes

Didanosine Overview

Didanosine is classified as a nucleoside reverse transcriptase inhibitor (RTI) and is an adenosine analogue.
Its brand names include Videx and Videx EC, with the abbreviation ddI commonly used.

Major Adverse Drug Reactions (ADRs)

Diarrhea is a notable side effect, often due to the buffer used in tablets and powder formulations.
Peripheral neuropathy is another significant ADR associated with didanosine.
Pancreatitis presents a serious potential risk when using this medication.

Drug Interactions

Didanosine has no major known drug interactions, making it relatively safe in terms of compatibility with other medications.

Dosing Considerations

Once daily (QD) dosing is feasible with the enteric-coated formulation.
For optimal effectiveness, didanosine should be taken on an empty stomach, enhancing absorption.
Renal function adjustments in dosing are recommended to ensure safety and efficacy in patients with compromised kidney function.

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Description

Test your knowledge about Didanosine, an important nucleoside reverse transcriptase inhibitor used in HIV treatment. This quiz covers its drug class, brand names, major adverse drug reactions (ADRs), interactions, and dosing information. Perfect for pharmacy students and healthcare professionals!