Podcast
Questions and Answers
What is the main advantage of Diaskintest compared to tuberculin?
What is the main advantage of Diaskintest compared to tuberculin?
It does not give a cross-reaction to the antigens of the BCG vaccine strain and most non-tuberculous mycobacteria.
What is the basis of the action of Diaskintest?
What is the basis of the action of Diaskintest?
The development of an immune response of the type of delayed-type hypersensitivity.
What is required for Diaskintest to be positive?
What is required for Diaskintest to be positive?
The presence of an active tuberculosis infection and an adequate immune response to specific antigens CFP 10 and ESAT6.
How long does it take to evaluate the result of Diaskintest?
How long does it take to evaluate the result of Diaskintest?
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What is the significance of the specificity of Diaskintest?
What is the significance of the specificity of Diaskintest?
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What properties of mycobacteria determine the virulence of MBT?
What properties of mycobacteria determine the virulence of MBT?
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Why does Diaskintest not give cross-reactions to the antigens of the BCG vaccine strain?
Why does Diaskintest not give cross-reactions to the antigens of the BCG vaccine strain?
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What type of immune response is responsible for the action of Diaskintest?
What type of immune response is responsible for the action of Diaskintest?
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What is the significance of the size of papules in Diaskintest?
What is the significance of the size of papules in Diaskintest?
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What is the advantage of Diaskintest in terms of false positive reactions?
What is the advantage of Diaskintest in terms of false positive reactions?
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Study Notes
Diaskintest: A Novel Intradermal Test for Tuberculosis Diagnosis
- Diaskintest is an innovative intradermal test that improves the quality of diagnosis of tuberculosis infection.
- The test is based on a recombinant protein, combining CFP10 and ESAT6, which are key proteins determining the virulence properties of Mycobacterium tuberculosis (MBT).
Mechanism of Diaskintest
- These proteins are not synthesized by the M.Bovis (BCG) vaccine strain or most non-tuberculous mycobacteria.
- Unlike tuberculin, Diaskintest does not cause a cross-reaction to the antigens of the BCG vaccine strain and most non-tuberculous mycobacteria.
Administration and Evaluation
- The setting of Diaskintest is identical to the Mantoux Test and does not require significant skills and material costs.
- The result of the reaction is evaluated after 72 hours.
Immune Response and Result
- Diaskintest is based on the development of an immune response of the delayed-type hypersensitivity type.
- The test is positive in the form of papules of any size, indicating an active tuberculosis infection and the reproduction of mycobacteria in individuals with an adequate immune response to specific antigens CFP10 and ESAT6.
Advantages and Accuracy
- Diaskintest has high specificity (almost 100%) and practically does not give false positive reactions associated with BCG vaccination and sensitization by non-tuberculous mycobacteria.
- It allows for accurate diagnosis of the active tuberculosis process and identification of infected individuals with a high risk of developing the disease.
Diaskintest: A Novel Intradermal Test for Tuberculosis Diagnosis
- Diaskintest is an innovative intradermal test that improves the quality of diagnosis of tuberculosis infection.
- The test is based on a recombinant protein, combining CFP10 and ESAT6, which are key proteins determining the virulence properties of Mycobacterium tuberculosis (MBT).
Mechanism of Diaskintest
- These proteins are not synthesized by the M.Bovis (BCG) vaccine strain or most non-tuberculous mycobacteria.
- Unlike tuberculin, Diaskintest does not cause a cross-reaction to the antigens of the BCG vaccine strain and most non-tuberculous mycobacteria.
Administration and Evaluation
- The setting of Diaskintest is identical to the Mantoux Test and does not require significant skills and material costs.
- The result of the reaction is evaluated after 72 hours.
Immune Response and Result
- Diaskintest is based on the development of an immune response of the delayed-type hypersensitivity type.
- The test is positive in the form of papules of any size, indicating an active tuberculosis infection and the reproduction of mycobacteria in individuals with an adequate immune response to specific antigens CFP10 and ESAT6.
Advantages and Accuracy
- Diaskintest has high specificity (almost 100%) and practically does not give false positive reactions associated with BCG vaccination and sensitization by non-tuberculous mycobacteria.
- It allows for accurate diagnosis of the active tuberculosis process and identification of infected individuals with a high risk of developing the disease.
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Description
This quiz covers the developments of Russian scientists in creating an innovative intradermal test called Diaskintest for diagnosing tuberculosis infection. Learn about the recombinant protein used in the test and how it improves diagnosis quality.
