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Questions and Answers

Which of the following is a characteristic of a lower motor neuron lesion?

  • Hyperreflexia
  • Exaggerated deep tendon reflexes
  • Muscle atrophy (correct)
  • Increased muscle tone

What is the function of the upper motor neuron?

  • Starts from brainstem and ends at muscle
  • Starts from motor cortex and ends at lower motor neuron
  • Controls voluntary movements (correct)
  • Controls involuntary movements

Which part of the nervous system is responsible for controlling skeletal muscles?

  • Lower motor neurons (correct)
  • Upper motor neurons
  • Motor cortex
  • Peripheral nerves

What are the clinical features of a lower motor neuron lesion?

<p>Muscle atrophy and hyporeflexia (C)</p> Signup and view all the answers

Where does the corticobulbar tract start and end?

<p>Motor cortex to brainstem (B)</p> Signup and view all the answers

What is the function of the corticospinal tract?

<p>Controls voluntary movements (C)</p> Signup and view all the answers

What are the clinical features of a lower motor neuron lesion?

<p>Muscle atrophy and hyporeflexia (A)</p> Signup and view all the answers

Which of the following is the cause of Spinal Muscular Atrophy (SMA)?

<p>Genetic (C)</p> Signup and view all the answers

What is the treatment for Amyotrophic Lateral Sclerosis (ALS)?

<p>Supportive care (C)</p> Signup and view all the answers

Which part of the nervous system does Amyotrophic Lateral Sclerosis (ALS) primarily affect?

<p>Spinal cord (A)</p> Signup and view all the answers

What is the term used to describe a degenerative motor neuron disease that affects both upper motor neurons (UMN) and lower motor neurons (LMN)?

<p>Motor neuron disease (B)</p> Signup and view all the answers

What is the term for the degeneration of the dorsal root ganglia and its projections?

<p>Ganglionopathy (C)</p> Signup and view all the answers

Which type of neuropathy can be hereditary or acquired?

<p>Peripheral neuropathy (B)</p> Signup and view all the answers

What is the term used to describe the condition when only one peripheral nerve is affected?

<p>Mononeuropathy (A)</p> Signup and view all the answers

Which of the following is a characteristic of lower motor neuron (LMN) lesions?

<p>Fasciculations (C)</p> Signup and view all the answers

Which of the following is a characteristic of upper motor neuron (UMN) lesions?

<p>Hoffmann sign (A)</p> Signup and view all the answers

Which of the following is a sign of an upper motor neuron (UMN) lesion?

<p>Positive Babinski response (D)</p> Signup and view all the answers

Which of the following is a sign of a lower motor neuron (LMN) lesion?

<p>Wasting (C)</p> Signup and view all the answers

Which of the following diseases is associated with a mixed upper motor neuron (UMN) and lower motor neuron (LMN) lesion?

<p>Amyotrophic lateral sclerosis (ALS) (D)</p> Signup and view all the answers

Which of the following is a characteristic of upper motor neuron (UMN) lesions?

<p>Presence of clonus (D)</p> Signup and view all the answers

Which of the following is a characteristic of lower motor neuron (LMN) lesions?

<p>Positive Hoffman sign (C)</p> Signup and view all the answers

Which of the following is NOT a treatment option for carpal tunnel syndrome?

<p>Surgery (D)</p> Signup and view all the answers

Which type of neuropathy affects multiple peripheral nerves simultaneously or sequentially?

<p>Mononeuropathy multiplex (D)</p> Signup and view all the answers

Which disease example is associated with mononeuropathy multiplex?

<p>Vasculitis of vasa nervorum (D)</p> Signup and view all the answers

What is the most common cause of polyneuropathy?

<p>Diabetes mellitus (C)</p> Signup and view all the answers

What is the classification of polyneuropathy based on?

<p>Nerve conduction study (A)</p> Signup and view all the answers

Which type of neuropathy affects the myelin sheath of the nerves?

<p>Demyelinating neuropathy (D)</p> Signup and view all the answers

What is the commonest cause of axonal neuropathy?

<p>Metabolic/endocrine disorders (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of carpal tunnel syndrome?

<p>Down-going toes on plantar reflex (C)</p> Signup and view all the answers

Which of the following is NOT expected in a patient with acute stroke?

<p>Hypotonia in right leg (D)</p> Signup and view all the answers

Which of the following is a characteristic of upper motor neuron (UMN) lesions?

<p>Increased muscle resistance to passive movement (A)</p> Signup and view all the answers

What is the term used to describe the condition when only one peripheral nerve is affected?

<p>Mononeuropathy (D)</p> Signup and view all the answers

Which part of the nervous system does Amyotrophic Lateral Sclerosis (ALS) primarily affect?

<p>Both upper and lower motor neurons (D)</p> Signup and view all the answers

What is the most common cause of polyneuropathy?

<p>Diabetes (B)</p> Signup and view all the answers

Which of the following is a sign of an upper motor neuron (UMN) lesion?

<p>Hyperreflexia (A)</p> Signup and view all the answers

What is the function of the corticospinal tract?

<p>Controls voluntary movements (A)</p> Signup and view all the answers

Which of the following is NOT a treatment option for carpal tunnel syndrome?

<p>Surgery (B)</p> Signup and view all the answers

Which of the following is a characteristic of lower motor neuron (LMN) lesions?

<p>Muscle hypertrophy (C)</p> Signup and view all the answers

What is the term used to describe the condition when only one peripheral nerve is affected?

<p>Mononeuropathy (B)</p> Signup and view all the answers

Where does the corticobulbar tract start and end?

<p>Starts from the motor cortex and ends at the lower motor neuron (LMN) (A)</p> Signup and view all the answers

Which disease example is associated with mononeuropathy multiplex?

<p>Carpal tunnel syndrome (D)</p> Signup and view all the answers

What is the most common cause of polyneuropathy?

<p>Vitamin B12 deficiency (C)</p> Signup and view all the answers

What is the term used to describe a degenerative motor neuron disease that affects both upper motor neurons (UMN) and lower motor neurons (LMN)?

<p>Amyotrophic lateral sclerosis (ALS) (D)</p> Signup and view all the answers

Which type of neuropathy can be hereditary or acquired?

<p>Polyneuropathy (C)</p> Signup and view all the answers

Which part of the nervous system does Spinal Muscular Atrophy (SMA) primarily affect?

<p>Anterior horn of spinal cord (B)</p> Signup and view all the answers

What is the cause of Amyotrophic Lateral Sclerosis (ALS)?

<p>Genetic factors (B)</p> Signup and view all the answers

Which of the following is a characteristic of mononeuropathy multiplex?

<p>Involvement of multiple peripheral nerves (B)</p> Signup and view all the answers

What is the treatment for Carpal Tunnel Syndrome?

<p>Surgical release of the flexor retinaculum (C)</p> Signup and view all the answers

Which part of the nervous system is responsible for controlling voluntary movements?

<p>Cerebral cortex (B)</p> Signup and view all the answers

What is the term used to describe the degeneration of the dorsal root ganglia and its projections?

<p>Ganglionopathy (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of upper motor neuron (UMN) lesions?

<p>Hypotonia (C)</p> Signup and view all the answers

Which of the following is a characteristic of carpal tunnel syndrome?

<p>Positive Hoffman’s sign (D)</p> Signup and view all the answers

What is the most common cause of polyneuropathy?

<p>Diabetes mellitus (B)</p> Signup and view all the answers

Which type of neuropathy affects multiple peripheral nerves simultaneously or sequentially?

<p>Mononeuropathy multiplex (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of lower motor neuron (LMN) lesions?

<p>Hyperreflexia (C)</p> Signup and view all the answers

Which part of the nervous system does Amyotrophic Lateral Sclerosis (ALS) primarily affect?

<p>Lower motor neurons (LMN) (A)</p> Signup and view all the answers

Which of the following is a sign of a lower motor neuron (LMN) lesion?

<p>Muscle weakness (B)</p> Signup and view all the answers

Which type of neuropathy affects the myelin sheath of the nerves?

<p>Demyelinating neuropathy (A)</p> Signup and view all the answers

Which of the following is a characteristic of upper motor neuron (UMN) lesions?

<p>Hyperreflexia (C)</p> Signup and view all the answers

Which of the following is NOT a treatment option for carpal tunnel syndrome?

<p>Wrist splint (C)</p> Signup and view all the answers

Which of the following is a characteristic of upper motor neuron (UMN) lesions?

<p>Increased muscle tone (D)</p> Signup and view all the answers

Which of the following is a characteristic of lower motor neuron (LMN) lesions?

<p>Decreased muscle tone (D)</p> Signup and view all the answers

What is the term used to describe the degeneration of the dorsal root ganglia and its projections?

<p>Disuse atrophy (D)</p> Signup and view all the answers

Which part of the nervous system does Amyotrophic Lateral Sclerosis (ALS) primarily affect?

<p>Lower motor neurons (D)</p> Signup and view all the answers

Which type of neuropathy can be hereditary or acquired?

<p>Polyneuropathy (B)</p> Signup and view all the answers

What is the most common cause of polyneuropathy?

<p>Diabetes (A)</p> Signup and view all the answers

Which of the following diseases is associated with a mixed upper motor neuron (UMN) and lower motor neuron (LMN) lesion?

<p>Amyotrophic lateral sclerosis (ALS) (A)</p> Signup and view all the answers

Which part of the nervous system is responsible for controlling voluntary movements?

<p>Upper motor neuron (B)</p> Signup and view all the answers

What are the clinical features of a lower motor neuron lesion?

<p>Muscle atrophy and hyporeflexia (D)</p> Signup and view all the answers

What is the most common cause of polyneuropathy?

<p>Diabetes mellitus (A)</p> Signup and view all the answers

Which of the following is a characteristic of upper motor neuron (UMN) lesions?

<p>Hyperreflexia (C)</p> Signup and view all the answers

Which disease example is associated with mononeuropathy multiplex?

<p>Guillain-Barre syndrome (A)</p> Signup and view all the answers

Which of the following is NOT a treatment option for carpal tunnel syndrome?

<p>Acupuncture (C)</p> Signup and view all the answers

What is the term used to describe a degenerative motor neuron disease that affects both upper motor neurons (UMN) and lower motor neurons (LMN)?

<p>Amyotrophic lateral sclerosis (ALS) (D)</p> Signup and view all the answers

Which of the following is a characteristic of amyotrophic lateral sclerosis (ALS)?

<p>Primarily affects the anterior horn of the spinal cord (B)</p> Signup and view all the answers

What is the term used to describe the degeneration of the dorsal root ganglia and its projections?

<p>Neuronopathy (D)</p> Signup and view all the answers

Which of the following is the most common cause of mononeuropathy?

<p>Compression or entrapment of peripheral nerves (C)</p> Signup and view all the answers

Which part of the nervous system does spinal muscular atrophy (SMA) primarily affect?

<p>Anterior horn of the spinal cord (D)</p> Signup and view all the answers

What is the term used to describe a condition when only one peripheral nerve is affected?

<p>Mononeuropathy (A)</p> Signup and view all the answers

What is the most common cause of polyneuropathy?

<p>Hereditary conditions affecting the myelin sheath (D)</p> Signup and view all the answers

What is the function of the corticospinal tract?

<p>Controls voluntary movements (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of carpal tunnel syndrome?

<p>Positive Hoffman's sign (B)</p> Signup and view all the answers

Which type of neuropathy affects multiple peripheral nerves simultaneously or sequentially?

<p>Mononeuropathy multiplex (A)</p> Signup and view all the answers

What is the most common cause of polyneuropathy?

<p>Diabetes mellitus (B)</p> Signup and view all the answers

Which of the following is a characteristic of upper motor neuron (UMN) lesions?

<p>Hyperreflexia with spasticity (B)</p> Signup and view all the answers

What is the cause of Amyotrophic Lateral Sclerosis (ALS)?

<p>Unknown (A)</p> Signup and view all the answers

What is the term used to describe the condition when only one peripheral nerve is affected?

<p>Mononeuropathy (B)</p> Signup and view all the answers

Which part of the nervous system does Spinal Muscular Atrophy (SMA) primarily affect?

<p>Motor neurons in the spinal cord (B)</p> Signup and view all the answers

Which of the following is a sign of an upper motor neuron (UMN) lesion?

<p>Hyperreflexia with spasticity (A)</p> Signup and view all the answers

Which of the following is NOT a treatment option for carpal tunnel syndrome?

<p>Surgery (C)</p> Signup and view all the answers

Flashcards

Lower Motor Neuron Lesion

A lower motor neuron (LMN) lesion is a damage to the nerve cell that directly controls skeletal muscle.

What is a Lower Motor Neuron Lesion?

A lower motor neuron (LMN) lesion is a damage to the nerve cell that directly controls skeletal muscle. This can result in a loss of muscle function, which can cause weakness or paralysis.

Upper Motor Neuron Function

The upper motor neuron (UMN) controls voluntary movements by sending signals from the brain to the lower motor neurons.

Function of Lower Motor Neurons

Lower motor neurons (LMN) are the nerve cells that directly control skeletal muscles. They receive commands from the upper motor neurons and transmit them to the muscles.

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Clinical Features of a Lower Motor Neuron Lesion

Muscle atrophy and hyporeflexia are common clinical features of a lower motor neuron (LMN) lesion.

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Corticobulbar Tract

The corticobulbar tract originates in the motor cortex of the brain and ends in the brainstem, controlling muscles of the face, tongue, and larynx.

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Function of Corticospinal Tract

The corticospinal tract originates in the motor cortex of the brain and ends in the spinal cord, controlling voluntary movements in the limbs.

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Clinical Features of Lower Motor Neuron Lesion

Muscle atrophy and hyporeflexia, decreased muscle tone, and fasciculations are common clinical features of a lower motor neuron lesion.

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Cause of Spinal Muscular Atrophy (SMA)

Spinal muscular atrophy (SMA) is a genetic condition affecting the lower motor neurons.

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ALS Treatment

Treatment for ALS is supportive care, focused on managing symptoms and improving the quality of life.

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Which Part of the Nervous System Does ALS Affect?

Amyotrophic lateral sclerosis (ALS) primarily affects the spinal cord and brainstem, leading to degeneration of both upper and lower motor neurons.

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Motor Neuron Disease

Motor neuron disease is a term used to describe a degenerative condition affecting both upper and lower motor neurons.

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Ganglionopathy

Ganglionopathy is a term used to describe degeneration of the dorsal root ganglia and their projections.

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Types of Peripheral Neuropathy

Peripheral neuropathy can be either hereditary or acquired, affecting the nerves outside of the brain and spinal cord.

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Mononeuropathy

Mononeuropathy is the term for a condition that affects only one peripheral nerve.

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Characteristic of Lower Motor Neuron (LMN) Lesions

Fasciculations, which are involuntary muscle twitches, is a characteristic feature of lower motor neuron (LMN) lesions.

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Characteristic of Upper Motor Neuron (UMN) Lesions

The Hoffmann sign, where tapping on the fingernail elicits a sudden flexion of the finger, is a characteristic feature of upper motor neuron (UMN) lesions.

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Sign of Upper Motor Neuron Lesion

The Babinski response, where the big toe dorsiflexes and the other toes fan out when the sole is stroked, is a sign of an upper motor neuron (UMN) lesion.

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Sign of Lower Motor Neuron (LMN) Lesion

Wasting (muscle atrophy) is a sign of a lower motor neuron (LMN) lesion.

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Disease Associated with Mixed UMN and LMN Lesion

Amyotrophic Lateral Sclerosis (ALS) is a disease associated with a mixed upper motor neuron (UMN) and lower motor neuron (LMN) lesion.

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Characteristic of Upper Motor Neuron (UMN) Lesions

Clonus, which is rhythmic involuntary muscle spasms, is a characteristic of upper motor neuron (UMN) lesions.

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Characteristic of Lower Motor Neuron (LMN) Lesions

The Hoffman sign, where tapping on the fingernail elicits a sudden flexion of the finger This is usually indicative of a lower motor neuron (LMN) lesion.

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Treatment Option for Carpal Tunnel Syndrome

Surgery is a treatment option for carpal tunnel syndrome, although not always the first choice.

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Mononeuropathy Multiplex

Mononeuropathy multiplex is a type of neuropathy affecting multiple peripheral nerves simultaneously or sequentially.

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Disease Example Associated with Mononeuropathy Multiplex

Vasculitis of vasa nervorum, inflammation of small blood vessels supplying the nerves, is an example of a disorder that can cause mononeuropathy multiplex.

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Most Common Cause of Polyneuropathy

Diabetes mellitus is the most common cause of polyneuropathy, a nerve disorder affecting multiple peripheral nerves.

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Polyneuropathy Classification

Polyneuropathy can be classified based on the results of a nerve conduction study, which measures the speed of nerve impulses.

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Demyelinating Neuropathy

Demyelinating neuropathy affects the myelin sheath, a fatty substance that insulates nerves.

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Commonest Cause of Axonal Neuropathy

Metabolic/endocrine disorders are the most common causes of axonal neuropathy, affecting the nerve fiber itself.

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Characteristic of Carpal Tunnel Syndrome

Carpal tunnel syndrome does not cause down-going toes on the plantar reflex. This is a characteristic of an upper motor neuron lesion.

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Characteristic of Acute Stroke

Hypotonia (decreased muscle tone) in the right leg is not expected in a patient with an acute stroke. Acute stroke typically causes hypertonia (increased muscle tone) in the affected limb.

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Characteristic of Upper Motor Neuron (UMN) Lesions

Increased muscle resistance to passive movement, known as spasticity, is a characteristic of upper motor neuron (UMN) lesions.

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Mononeuropathy

Mononeuropathy is the term for a condition that affects only one peripheral nerve.

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Which Part Of The Nervous System Does ALS Affect?

Amyotrophic lateral sclerosis (ALS) primarily affects both upper and lower motor neurons, leading to a degeneration of the motor pathways that control movement.

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Most Common Cause of Polyneuropathy

Diabetes is the most common cause of polyneuropathy, affecting multiple peripheral nerves.

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Sign of Upper Motor Neuron (UMN) Lesion

Hyperreflexia, or an increased reflex response, is a sign of an upper motor neuron (UMN) lesion.

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Function of Corticospinal Tract

The corticospinal tract originates in the motor cortex and ends in the spinal cord, controlling voluntary movements in the limbs.

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Treatment Option for Carpal Tunnel Syndrome

Surgery is a treatment option for carpal tunnel syndrome, but it's not the only option.

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Characteristic of Lower Motor Neuron (LMN) Lesions

Muscle hypertrophy, an increase in muscle size, is not a characteristic of lower motor neuron (LMN) lesions. LMN lesions typically lead to muscle atrophy.

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Mononeuropathy

Mononeuropathy is the term for a condition that affects only one peripheral nerve.

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Corticobulbar Tract Pathway

The corticobulbar tract starts in the motor cortex and ends at the lower motor neuron (LMN) in the brainstem, controlling facial muscles.

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Disease Example Associated with Mononeuropathy Multiplex

Carpal tunnel syndrome is not associated with mononeuropathy multiplex. It is a condition that affects only the median nerve in the wrist.

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Most Common Cause of Polyneuropathy

Vitamin B12 deficiency is a common cause of polyneuropathy, affecting multiple peripheral nerves.

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Motor Neuron Disease

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease affecting both upper and lower motor neurons.

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Types of Peripheral Neuropathy

Polyneuropathy can be either hereditary or acquired, affecting multiple peripheral nerves.

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Which Part Of The Nervous System Does SMA Affect?

Spinal muscular atrophy (SMA) primarily affects the anterior horn of the spinal cord, which contains the lower motor neurons.

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Cause of Amyotrophic Lateral Sclerosis (ALS)

The cause of amyotrophic lateral sclerosis (ALS) is not fully understood, but it is believed to be caused by a combination of genetic and environmental factors.

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Characteristic of Mononeuropathy Multiplex

Mononeuropathy multiplex is a condition that often affects multiple peripheral nerves simultaneously or sequentially, and is not restricted to one particular nerve.

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Treatment for Carpal Tunnel Syndrome

Treatment for carpal tunnel syndrome often includes surgical release of the flexor retinaculum, which is a band of tissue that can compress the median nerve.

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Controlling Voluntary Movements

The cerebral cortex is the part of the brain responsible for controlling voluntary movements.

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Ganglionopathy

Ganglionopathy is a term used to describe degeneration of the dorsal root ganglia and their projections.

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Study Notes

Characteristics of Upper Motor Neuron (UMN) and Lower Motor Neuron (LMN) Lesions

  • A lower motor neuron lesion is characterized by flaccid paralysis, muscle atrophy, and decreased or absent deep tendon reflexes.
  • An upper motor neuron lesion is characterized by spastic paralysis, increased deep tendon reflexes, and a positive Babinski sign.

Functions of Upper Motor Neurons and Corticospinal Tract

  • The upper motor neuron is responsible for controlling voluntary movements.
  • The corticospinal tract is responsible for transmitting motor signals from the cerebral cortex to the spinal cord.

Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS)

  • Spinal Muscular Atrophy (SMA) is a genetic disorder that affects the lower motor neurons, resulting in muscle atrophy and weakness.
  • Amyotrophic Lateral Sclerosis (ALS) is a degenerative motor neuron disease that affects both upper motor neurons and lower motor neurons, leading to muscle weakness, atrophy, and paralysis.

Neuropathy

  • Mononeuropathy is a condition where only one peripheral nerve is affected.
  • Polyneuropathy is a condition where multiple peripheral nerves are affected simultaneously or sequentially.
  • Axonal neuropathy affects the axon of the nerve, while demyelinating neuropathy affects the myelin sheath.
  • The most common cause of polyneuropathy is diabetes.

Carpal Tunnel Syndrome

  • Carpal tunnel syndrome is a type of mononeuropathy that affects the median nerve in the wrist.
  • Treatment options for carpal tunnel syndrome include medication, physical therapy, and surgery.

Motor Neuron Diseases

  • Amyotrophic Lateral Sclerosis (ALS) is a degenerative motor neuron disease that affects both upper motor neurons and lower motor neurons.
  • The term used to describe a degenerative motor neuron disease that affects both upper motor neurons and lower motor neurons is motor neuron disease.

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Description

Test your knowledge on the diagnosis, treatment, and prevention of 1% à LMN picture, Spinal Muscular Atrophy (SMA), and Amyotrophic Lateral Sclerosis (ALS). Learn about the genetic causes, clinical presentations, and molecular genetic testing for these conditions. Discover the latest treatment options, including antisense oligonucleotide (ASO) therapy, and how to prevent them through OPV/IPV vaccination.

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