Podcast
Questions and Answers
Which organism is predominantly associated with cellulitis in diabetic patients?
Which organism is predominantly associated with cellulitis in diabetic patients?
- Pseudomonas
- Streptococcus pyogenes (correct)
- Escherichia coli
- Clostridium perfringens
What is the initial empiric treatment for cellulitis?
What is the initial empiric treatment for cellulitis?
- Flucloxacillin (correct)
- Benzylpenicillin
- Vancomycin
- Clindamycin
Which clinical feature is NOT associated with Fournier Gangrene?
Which clinical feature is NOT associated with Fournier Gangrene?
- Skin dimpling (correct)
- Purplish rash
- Necrosis
- Dizziness
For necrotising fasciitis, what is the recommended treatment approach?
For necrotising fasciitis, what is the recommended treatment approach?
Which of the following organisms is NOT commonly associated with Fournier Gangrene?
Which of the following organisms is NOT commonly associated with Fournier Gangrene?
Which blood test is essential for diagnosing infections in patients with diabetes mellitus?
Which blood test is essential for diagnosing infections in patients with diabetes mellitus?
What imaging method is recommended if osteomyelitis is suspected but not evident on a plain X-ray?
What imaging method is recommended if osteomyelitis is suspected but not evident on a plain X-ray?
What is a recommended vascular assessment for diabetic patients suspected of having an infection?
What is a recommended vascular assessment for diabetic patients suspected of having an infection?
Which test is specifically used to evaluate the impact of neuropathy in suspected diabetic infections?
Which test is specifically used to evaluate the impact of neuropathy in suspected diabetic infections?
In patients with diabetes, what is the importance of screening for MRSA prior to an investigation?
In patients with diabetes, what is the importance of screening for MRSA prior to an investigation?
Which urine collection method helps prevent bacterial overgrowth if there is a delay of ≥4 hours before transport to the laboratory?
Which urine collection method helps prevent bacterial overgrowth if there is a delay of ≥4 hours before transport to the laboratory?
What is considered the gold standard for diagnosing osteomyelitis in patients with diabetic foot infections?
What is considered the gold standard for diagnosing osteomyelitis in patients with diabetic foot infections?
Why is it advised to obtain specimens from diabetic foot ulcers before starting antimicrobial therapy?
Why is it advised to obtain specimens from diabetic foot ulcers before starting antimicrobial therapy?
Which factor is NOT part of the clinical diagnosis criteria for infection in diabetic foot infections?
Which factor is NOT part of the clinical diagnosis criteria for infection in diabetic foot infections?
What should be done to a wound before obtaining a tissue specimen for a diabetic foot infection?
What should be done to a wound before obtaining a tissue specimen for a diabetic foot infection?
What procedure was performed by the podiatrist on the patient?
What procedure was performed by the podiatrist on the patient?
What is the role of a 'probe to bone test' in diabetes-related foot infections?
What is the role of a 'probe to bone test' in diabetes-related foot infections?
What was noted by the endocrinology registrar regarding the patient's condition?
What was noted by the endocrinology registrar regarding the patient's condition?
Which antibiotic is indicated as the most appropriate management for the patient?
Which antibiotic is indicated as the most appropriate management for the patient?
Which of the following is an important consideration when choosing appropriate antimicrobial agents for infections in people with diabetes mellitus?
Which of the following is an important consideration when choosing appropriate antimicrobial agents for infections in people with diabetes mellitus?
Why is obtaining a swab from an ulcer often not reliable for diagnosing infection?
Why is obtaining a swab from an ulcer often not reliable for diagnosing infection?
Which statement is incorrect regarding the need for intravenous antibiotics for this patient?
Which statement is incorrect regarding the need for intravenous antibiotics for this patient?
Which of the following correctly summarizes the findings regarding the patient's allergy history?
Which of the following correctly summarizes the findings regarding the patient's allergy history?
What is the recommended initial treatment for mild to moderate cellulitis without a foot ulcer?
What is the recommended initial treatment for mild to moderate cellulitis without a foot ulcer?
In severe infections, what is the primary action to take pending culture results?
In severe infections, what is the primary action to take pending culture results?
What is a key factor in preventing foot ulcers for diabetic patients?
What is a key factor in preventing foot ulcers for diabetic patients?
Which therapy is indicated for suspected osteomyelitis?
Which therapy is indicated for suspected osteomyelitis?
Which of the following is essential for managing wounds promptly in diabetic patients?
Which of the following is essential for managing wounds promptly in diabetic patients?
Which medical condition should diabetic patients manage to reduce infection risk?
Which medical condition should diabetic patients manage to reduce infection risk?
For a patient with a deep foot ulcer requiring admission, which of the following treatments is appropriate?
For a patient with a deep foot ulcer requiring admission, which of the following treatments is appropriate?
What impact does glycaemic control have on infection rates in diabetic patients?
What impact does glycaemic control have on infection rates in diabetic patients?
What is the recommended duration of empiric treatment for osteomyelitis?
What is the recommended duration of empiric treatment for osteomyelitis?
Which of the following vaccinations is recommended for diabetic patients?
Which of the following vaccinations is recommended for diabetic patients?
Which of the following factors does not typically indicate the need for Pseudomonas coverage?
Which of the following factors does not typically indicate the need for Pseudomonas coverage?
Which therapy is suggested to improve immune function in diabetic patients?
Which therapy is suggested to improve immune function in diabetic patients?
What non-medical intervention can help improve the immune system in people with diabetes?
What non-medical intervention can help improve the immune system in people with diabetes?
Which practice should diabetic patients avoid to reduce the risk of infection?
Which practice should diabetic patients avoid to reduce the risk of infection?
What should diabetic patients regularly do as part of foot care?
What should diabetic patients regularly do as part of foot care?
What type of footwear is essential for diabetes patients to help reduce ulcer risk?
What type of footwear is essential for diabetes patients to help reduce ulcer risk?
What percentage of necrotizing otitis externa cases are reported to be associated with diabetes mellitus?
What percentage of necrotizing otitis externa cases are reported to be associated with diabetes mellitus?
Which condition is a potential complication from necrotizing otitis externa?
Which condition is a potential complication from necrotizing otitis externa?
What is the most common organism responsible for necrotizing otitis externa in diabetic patients?
What is the most common organism responsible for necrotizing otitis externa in diabetic patients?
What treatment is indicated for necrotizing otitis externa in diabetic patients?
What treatment is indicated for necrotizing otitis externa in diabetic patients?
Which of the following clinical features is typically observed in cases of necrotizing otitis externa?
Which of the following clinical features is typically observed in cases of necrotizing otitis externa?
What are the common clinical features associated with necrotising fasciitis?
What are the common clinical features associated with necrotising fasciitis?
Which organism is considered a common cause of Fournier Gangrene?
Which organism is considered a common cause of Fournier Gangrene?
What is the appropriate initial treatment strategy for cellulitis in diabetic patients?
What is the appropriate initial treatment strategy for cellulitis in diabetic patients?
Which statement accurately describes a feature of the organism group commonly responsible for cellulitis?
Which statement accurately describes a feature of the organism group commonly responsible for cellulitis?
What is a characteristic finding in the clinical presentation of Fournier Gangrene?
What is a characteristic finding in the clinical presentation of Fournier Gangrene?
What is the primary causative factor of Type 1 diabetes mellitus?
What is the primary causative factor of Type 1 diabetes mellitus?
What percentage of infections-related deaths is suggested to be associated with diabetes mellitus?
What percentage of infections-related deaths is suggested to be associated with diabetes mellitus?
Which of the following is the strongest association of infections in individuals with diabetes mellitus?
Which of the following is the strongest association of infections in individuals with diabetes mellitus?
Which statement best summarizes the relationship between hyperglycaemia and infection outcomes in diabetic patients?
Which statement best summarizes the relationship between hyperglycaemia and infection outcomes in diabetic patients?
In the context of diabetes mellitus, what age range is noted for the average diagnosis of Type 2 diabetes?
In the context of diabetes mellitus, what age range is noted for the average diagnosis of Type 2 diabetes?
What percentage of diabetics in Ireland are diagnosed with Type 2 diabetes mellitus?
What percentage of diabetics in Ireland are diagnosed with Type 2 diabetes mellitus?
What is a common characteristic of infections in diabetic patients compared to the general population?
What is a common characteristic of infections in diabetic patients compared to the general population?
What is the relevance of family history in Type 2 diabetes mellitus diagnosis?
What is the relevance of family history in Type 2 diabetes mellitus diagnosis?
What is the most effective treatment for onychomycosis in diabetic patients?
What is the most effective treatment for onychomycosis in diabetic patients?
Which condition is most commonly associated with mucormycosis in diabetic patients?
Which condition is most commonly associated with mucormycosis in diabetic patients?
Which organism is identified as the most common cause of genitourinary infections in diabetes?
Which organism is identified as the most common cause of genitourinary infections in diabetes?
What diagnostic method is essential for confirming mucormycosis?
What diagnostic method is essential for confirming mucormycosis?
Which complication is NOT typically associated with onychomycosis in diabetic patients?
Which complication is NOT typically associated with onychomycosis in diabetic patients?
What is a significant factor that increases the risk of genitourinary fungal infections in diabetic patients?
What is a significant factor that increases the risk of genitourinary fungal infections in diabetic patients?
Which clinical feature is least associated with mucormycosis in diabetic patients?
Which clinical feature is least associated with mucormycosis in diabetic patients?
Which treatment is considered first-line for symptomatic genitourinary fungal infections in diabetic patients?
Which treatment is considered first-line for symptomatic genitourinary fungal infections in diabetic patients?
What is the preferred method for collecting urine samples to prevent bacterial overgrowth if transport to the lab is delayed?
What is the preferred method for collecting urine samples to prevent bacterial overgrowth if transport to the lab is delayed?
Which type of specimen is considered the gold standard for diagnosing osteomyelitis in diabetic foot infections?
Which type of specimen is considered the gold standard for diagnosing osteomyelitis in diabetic foot infections?
Which clinical assessment is crucial when determining the site of infection in diabetic patients?
Which clinical assessment is crucial when determining the site of infection in diabetic patients?
What should be done before obtaining a tissue specimen from a diabetic foot ulcer?
What should be done before obtaining a tissue specimen from a diabetic foot ulcer?
Which of the following guidelines should be consulted when choosing empiric antibiotics for infections in diabetic patients?
Which of the following guidelines should be consulted when choosing empiric antibiotics for infections in diabetic patients?
When collecting specimens from a diabetic foot infection, which of the following is least recommended?
When collecting specimens from a diabetic foot infection, which of the following is least recommended?
What aspect is critical in considering the clinical diagnosis of infection in diabetic foot matters?
What aspect is critical in considering the clinical diagnosis of infection in diabetic foot matters?
What is a significant consideration when interpreting swabs taken from ulcerations in diabetic foot infections?
What is a significant consideration when interpreting swabs taken from ulcerations in diabetic foot infections?
What is a primary concern when evaluating a patient with a history of allergy to antibiotics?
What is a primary concern when evaluating a patient with a history of allergy to antibiotics?
Which of the following factors is least relevant when determining the severity of cellulitis?
Which of the following factors is least relevant when determining the severity of cellulitis?
In the context of diabetic foot infections, what is the significance of colonized antibiotic-resistant organisms?
In the context of diabetic foot infections, what is the significance of colonized antibiotic-resistant organisms?
What is the most critical immediate intervention for a patient with suspected diabetic foot osteomyelitis?
What is the most critical immediate intervention for a patient with suspected diabetic foot osteomyelitis?
Which of the following is NOT an appropriate consideration when evaluating the source of infection in a patient?
Which of the following is NOT an appropriate consideration when evaluating the source of infection in a patient?
For a patient with cellulitis, which of the following vital sign changes would indicate potential severity?
For a patient with cellulitis, which of the following vital sign changes would indicate potential severity?
What role does previous microbiology data play in managing ongoing infections?
What role does previous microbiology data play in managing ongoing infections?
What is typically an indicator that source control measures might be needed?
What is typically an indicator that source control measures might be needed?
Flashcards
What is Cellulitis?
What is Cellulitis?
A common skin infection that affects people with diabetes. It's characterized by red, swollen, and painful skin that's warm to the touch. This infection can often be caused by bacteria like Staphylococcus aureus and Streptococcus pyogenes. Treatment usually involves antibiotics like flucloxacillin and adjusting the antibiotic based on the specific bacteria causing the infection.
Explain Necrotizing Fasciitis.
Explain Necrotizing Fasciitis.
This dangerous infection rapidly spreads through the deeper layers of skin and tissue, potentially leading to limb loss. It involves multiple types of bacteria, with Group A strep being a common culprit. Prompt and aggressive treatment is crucial, including surgical removal of infected tissue and broad-spectrum antibiotics.
Describe Fournier Gangrene.
Describe Fournier Gangrene.
A severe infection that affects the soft tissue and fascia, often caused by a combination of bacteria, including Staphylococcus aureus, Pseudomonas, and Clostridium perfringens. It can spread quickly and lead to tissue death. Treatment involves prompt surgical removal of dead tissue and wide-spectrum antibiotics.
How is Cellulitis treated?
How is Cellulitis treated?
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What is the primary treatment for Necrotizing Fasciitis?
What is the primary treatment for Necrotizing Fasciitis?
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Blood Culture
Blood Culture
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Chest X-ray (CXR)
Chest X-ray (CXR)
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Ankle Brachial Index (ABI)
Ankle Brachial Index (ABI)
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Nerve Conduction Studies
Nerve Conduction Studies
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MRI of the foot or bone scan
MRI of the foot or bone scan
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Cellulitis
Cellulitis
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Osteomyelitis
Osteomyelitis
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Broad spectrum antibiotic
Broad spectrum antibiotic
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Narrow spectrum antibiotic
Narrow spectrum antibiotic
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Systemic inflammatory response syndrome (SIRS)
Systemic inflammatory response syndrome (SIRS)
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Vancomycin
Vancomycin
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Co-amoxiclav
Co-amoxiclav
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Piperacillin-tazobactam
Piperacillin-tazobactam
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Flucloxacillin
Flucloxacillin
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Bone Scan
Bone Scan
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Doxycycline
Doxycycline
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Probe-to-Bone Test
Probe-to-Bone Test
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Tissue specimen from the Base of a Debrided Ulcer
Tissue specimen from the Base of a Debrided Ulcer
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Classic Symptoms and Signs of Inflammation or Purulence
Classic Symptoms and Signs of Inflammation or Purulence
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Urine Container with Boric Acid
Urine Container with Boric Acid
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Midstream Urine Sample
Midstream Urine Sample
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Choosing Empiric Antibiotics
Choosing Empiric Antibiotics
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Revised Guidelines on Diabetic Foot Infection
Revised Guidelines on Diabetic Foot Infection
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Risk Factors for Diabetic Foot Infection
Risk Factors for Diabetic Foot Infection
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Healthy Diet for Diabetes
Healthy Diet for Diabetes
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Foot self-examination
Foot self-examination
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Proper Footwear
Proper Footwear
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Seeing a Podiatrist
Seeing a Podiatrist
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Promptly Addressing Foot Wounds
Promptly Addressing Foot Wounds
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Glucose Control for Foot Health
Glucose Control for Foot Health
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Managing Other Medical Conditions
Managing Other Medical Conditions
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Vaccinations for Diabetes
Vaccinations for Diabetes
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Diabetes and Infections
Diabetes and Infections
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Diabetes Weakens Immune System
Diabetes Weakens Immune System
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Impaired Immune Response in Diabetic Patients
Impaired Immune Response in Diabetic Patients
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Why Infections Are More Common In Diabetes?
Why Infections Are More Common In Diabetes?
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High Blood Sugar and Infections
High Blood Sugar and Infections
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Glucose Control Reduces Infections
Glucose Control Reduces Infections
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Importance of Glucose Control in Diabetes
Importance of Glucose Control in Diabetes
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Glucose Control And Infection Prevention
Glucose Control And Infection Prevention
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What is Necrotizing Otitis Externa?
What is Necrotizing Otitis Externa?
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Which bacteria is often behind Necrotizing Otitis Externa?
Which bacteria is often behind Necrotizing Otitis Externa?
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How is Necrotizing Otitis Externa treated?
How is Necrotizing Otitis Externa treated?
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Why are diabetics at higher risk for Necrotizing Otitis Externa?
Why are diabetics at higher risk for Necrotizing Otitis Externa?
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How can Necrotizing Otitis Externa be prevented?
How can Necrotizing Otitis Externa be prevented?
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Necrotising Fasciitis
Necrotising Fasciitis
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Fournier Gangrene
Fournier Gangrene
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Empiric Therapy
Empiric Therapy
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Onychomycosis in Diabetes
Onychomycosis in Diabetes
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Mucormycosis in Diabetes
Mucormycosis in Diabetes
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Genitourinary Candida in Diabetes
Genitourinary Candida in Diabetes
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Onychomycosis Treatment
Onychomycosis Treatment
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Mucormycosis Diagnosis
Mucormycosis Diagnosis
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Genitourinary Candida Treatment
Genitourinary Candida Treatment
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Mucormycosis Treatment Approach
Mucormycosis Treatment Approach
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Diabetes and Fungal Infections
Diabetes and Fungal Infections
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Factors to consider when choosing an antibiotic
Factors to consider when choosing an antibiotic
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Importance of infection site in antibiotic choice
Importance of infection site in antibiotic choice
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Source control for infection management
Source control for infection management
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Impact of previous microbiology on antibiotic choice
Impact of previous microbiology on antibiotic choice
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Bactericidal vs. bacteriostatic antibiotics
Bactericidal vs. bacteriostatic antibiotics
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Diabetes and its impact on infections
Diabetes and its impact on infections
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Link between high blood sugar and infections in diabetes
Link between high blood sugar and infections in diabetes
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Importance of blood sugar control for infection prevention in diabetes
Importance of blood sugar control for infection prevention in diabetes
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Study Notes
Infections in People with Diabetes Mellitus
- Diabetes Mellitus (DM) is associated with a higher risk of infection.
- Type 1 and type 2 DM are linked to increased risk of infection-related hospitalisation and death.
- DM is associated with more frequent infections, poorer response to therapy, and more rapid progression to severe infection forms.
- Controlling hyperglycaemia can improve outcomes.
Diabetes Mellitus
- Inadequate insulin action results in hyperglycaemia.
- Type 1 DM is caused by autoimmune destruction of insulin-secreting cells, leading to absolute insulin deficiency.
- Type 2 DM is characterized by relative inadequacy of insulin action due to end-organ insulin resistance.
- Approximately 87.9% of diabetics in Ireland are Type 2.
- Average age at diagnosis of Type 2 DM is in the 5th or 6th decade of life.
- Family history and asymptomatic presentation are often common
Diabetes and Infection
- Infections in people with DM are more frequent.
- People with DM have poorer responses to therapy for infections.
- Infections in people with DM progress more quickly to severe forms.
- Controlling hyperglycaemia can improve outcomes.
Immune System Disruption in Diabetes
- Disruption of the immune system affects both Type 1 and Type 2 DM.
- Innate immunity, adaptive immunity, and cytokine signalling are affected in DM.
- Microvascular complications like neuropathy increase susceptibility to accidental skin lesions.
- Poor vascular flow compromises the immune response and wound healing.
- Infection severity can worsen as a result of poor wound healing.
Infections Associated with Diabetes (Examples)
- Urinary Tract Infections (UTIs): Women with DM have a higher risk of UTIs; E. coli is a common causative organism. Urine culture is crucial for diagnosis and treatment. Asymptomatic bacteriuria should not be treated. Treatment decisions should consider local antibiotic resistance trends.
- Pneumonia: Streptococcus species are the most common cause of community-acquired pneumonia. Gram-negative anaerobes commonly cause aspiration pneumonia. CURB-65 (Confusion, Urea, Respiratory Rate, Blood pressure, Age) assessment is used for treatment decisions..
- Skin and Soft Tissue Infections (SSTIs): Staphylococcus aureus, Streptococcus pyogenes are the most common organisms. Treatment for SSTIs involves debridement and broad-spectrum antibiotics.
- Hepatitis C: 33% of chronic hepatitis C patients have type 2 diabetes. NAFLD (Non-alcoholic fatty liver disease) is more common in T2DM. Hepatitis C impacts worse with frequent cirrhosis and failure of antivirals.
- Gastrointestinal Infections (e.g., cholecystitis): Clostridium perfringens, Klebsiella species, and E. coli are common organisms. Treatment usually involves surgical removal (cholecystectomy) but antibiotics can be helpful in mild cases.
- Necrotizing Otitis Externa: Pseudomonas aeruginosa is the common organism, and is significantly more common in diabetics. Systemic antibiotics and local cleaning/debridement are essential therapies.
- Onychomycosis (Nail Fungus): Infections are twice as common in people with DM, sometimes affecting up to 1/3 of patients. Fungal culture and microscopy are important for diagnosis and oral antifungals are typically the most effective treatment.
- Mucormycosis: Mucor or Rhizopus-type molds, causing a severe infection that often involves the sinuses, lungs, or skin. Tissue biopsy and imaging are needed for accurate diagnosis in suspected cases. Debulking of infected tissue and adjuvant antifungal treatment are important.
- Genitourinary Infections: Candida species infections are more common in people with DM. Fluconazole is typically used as first-line treatment if symptomatic.
Laboratory Diagnosis of Infections in DM
- Blood cultures, cultures from infection sites (urine, tissue, bone), and MRSA screenings are vital.
- Radiological investigations like CXR (chest X-ray), X-rays of the affected joint or foot, and MRI are used to diagnose infection. Also importantly, vascular assessments (e.g., ankle brachial index and toe pressure checks) are crucial..
- Diabetic patients need careful collection of urine samples (e.g., midstream).
Antimicrobial Treatment Options
-
Mild or moderate cellulitis without a foot ulcer: Start with empiric therapy (e.g. flucloxacillin) but consider MRSA risk factors. Then, adjust based on culture and susceptibility results. For example, moving to benzylpenicillin if Streptococcus pyogenes is confirmed.
-
Severe cellulitis or cellulitis with foot ulcer: Requires IV flucloxacillin (or Vancomycin if there is a known/suspected MRSA risk factor).
-
Infections requiring admission (e.g., deep foot ulcers): Anaerobic coverage (e.g., co-amoxiclav or piperacillin-tazobactam) should be included.
Preventative Measures for Infection in People with DM
- Lifestyle: Physical activity, smoking cessation, good hygiene (handwashing, avoiding sharing personal items), and a balanced diet rich in fruits, vegetables, and whole grains are essential.
- Foot care: Regular foot inspection, appropriate footwear, and prompt wound care can reduce the risk of diabetic foot ulcers.
- Vaccinations: Vaccination (e.g., against influenza, pneumococcal disease, COVID-19) is recommended to reduce the risk of infections.
- Glucose control: Tight glycemic control is essential to improve immune system function and reduce the risk of infection.
How to Determine Infection Severity
- Mild: Local infection.
- Moderate: Deeper infection symptoms; local erythema > 0.5 to < 5 cms.
- Severe: Local infection signs plus 2 or more systemic signs, indicating a severe inflammatory response.
Other Medical Measures for Prevention
- Diabetes management of other conditions (e.g., cardiovascular disease, hypertension) can also significantly impact infection risk.
- Vaccination against common infections like COVID-19 and influenza is essential.
Case Examples
- Specific case examples and their corresponding management strategies are detailed in supplementary documents.
Important Considerations for Management
- Prompt diagnosis and treatment are essential for minimizing complications and improving patient outcomes.
- Regular follow up with podiatry and appropriate specialists is vital.
- Clinical assessment, history-taking, and physical examination are crucial for an accurate diagnosis.
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Description
Test your knowledge on infections commonly seen in diabetic patients, including cellulitis, Fournier Gangrene, and necrotising fasciitis. This quiz covers the associated organisms, treatment approaches, and diagnostic procedures important for managing infections in diabetes. Assess your understanding of the critical aspects of diabetic infection management.