Diabetes Mellitus Overview Quiz
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Questions and Answers

What characterizes the group of disorders known as Diabetes Mellitus?

  • High levels of glucagon secretion
  • Low blood glucose levels
  • Hyperglycaemia due to insulin resistance (correct)
  • Normal carbohydrate metabolism

Which statement about normal carbohydrate metabolism is incorrect?

  • Blood glucose levels are maintained between 4-8 mmol/L.
  • Glucose can be oxidized to yield ATP.
  • Glycogenolysis is continuously inhibited in muscle tissues. (correct)
  • Insulin release is stimulated after eating complex carbohydrates.

How does prolonged fasting affect energy source preferences in the body?

  • Brain cells solely depend on glucose for energy.
  • Liver cells cannot metabolize fatty acids during fasting.
  • Only glucose is utilized as an energy source.
  • Fatty acids become increasingly important, while glucose use decreases. (correct)

What triggers insulin secretion from the pancreas?

<p>Ingestion of complex carbohydrates (D)</p> Signup and view all the answers

Which metabolic process is inhibited by insulin?

<p>Gluconeogenesis (A)</p> Signup and view all the answers

What happens to blood glucose levels after a meal?

<p>They rise due to hydrolysis of complex carbohydrates. (A)</p> Signup and view all the answers

Which energy source can cross the blood-brain barrier when blood glucose levels are low?

<p>Ketone bodies (C)</p> Signup and view all the answers

In the context of carbohydrate metabolism, what role does glucagon play?

<p>Activates gluconeogenesis when blood glucose levels are low (B)</p> Signup and view all the answers

What is the primary purpose of glycogen synthesis?

<p>To store excess glucose for future energy needs (C)</p> Signup and view all the answers

What is the primary diagnostic criterion for diabetes mellitus when symptoms are present?

<p>Random venous plasma glucose concentration &gt; 11.1 mmol/L (C)</p> Signup and view all the answers

Which of the following pre-analytical factors is NOT critical for accurate plasma glucose measurement?

<p>Environmental temperature during collection (C)</p> Signup and view all the answers

What is the function of sodium fluoride in plasma glucose testing?

<p>To inhibit enzymes involved in glycolysis (C)</p> Signup and view all the answers

Which statement regarding HbA1c formation is accurate?

<p>HbA1c is formed by the glycation of the N-terminal valine residue of β-chain of Hb A with glucose. (B)</p> Signup and view all the answers

Which of the following is the best indication of diabetes prevalence trends in socioeconomic regions by 2045?

<p>Color-coded geographic mapping (A)</p> Signup and view all the answers

Which statement about diagnosing diabetes mellitus with no symptoms is correct?

<p>Diagnosis requires elevated glucose levels on at least two occasions. (A)</p> Signup and view all the answers

Which glucose measurement must be taken two hours after a glucose load to confirm diabetes?

<p>Plasma glucose concentration after consuming 75g anhydrous glucose (B)</p> Signup and view all the answers

What is a common complication associated with advanced glycation end products (AGE) formed in diabetes?

<p>Microvascular and macrovascular complications (B)</p> Signup and view all the answers

What essential factor should be documented to ensure accurate interpretation of plasma glucose levels?

<p>Time and fasting state of the patient (A)</p> Signup and view all the answers

Which test result is considered definitive for diagnosing diabetes when performed with no symptoms?

<p>Plasma glucose &gt; 11.1 mmol/L on two occasions (B)</p> Signup and view all the answers

What is the average lifespan of a red blood cell that contributes to blood glucose concentration measurement?

<p>120 days (B)</p> Signup and view all the answers

In which units is Hb A1c now predominantly measured?

<p>mmol of Hb A1c per mol of Hb A (A)</p> Signup and view all the answers

Which of the following conditions can lead to a falsely low Hb A1c result?

<p>Haemolytic disease (A)</p> Signup and view all the answers

What is the Hb A1c diagnostic threshold for diabetes mellitus in IFCC units?

<blockquote> <p>48 mmol/mol (C)</p> </blockquote> Signup and view all the answers

Which maternal risk factor is NOT associated with gestational diabetes?

<p>Age over 35 (B)</p> Signup and view all the answers

What screening method leads to more women being diagnosed with gestational diabetes?

<p>One-step approach (B)</p> Signup and view all the answers

What complication is NOT associated with gestational diabetes?

<p>Chronic hypertension (B)</p> Signup and view all the answers

Which factors can interfere with the measurement of Hb A1c?

<p>Haemoglobin variants (C)</p> Signup and view all the answers

What is a key factor leading to an increase in Hb A1c values?

<p>Increased RBC lifespan (D)</p> Signup and view all the answers

Which of the following statements is true regarding gestational diabetes screening?

<p>One-step screening uses a 75 g OGTT at a single visit. (D)</p> Signup and view all the answers

Which lifestyle factor is NOT associated with an increased risk of Type 2 Diabetes Mellitus (T2DM)?

<p>Regular exercise (C)</p> Signup and view all the answers

What physiological change occurs in the pancreas in response to insulin resistance in T2DM?

<p>It maintains insulin production through cell hypertrophy. (C)</p> Signup and view all the answers

What percentage of individuals with Type 2 Diabetes Mellitus (T2DM) is likely to have a family history of the disease?

<p>75-90% (A)</p> Signup and view all the answers

Which characteristic is typically observed in children with Type 1 Diabetes Mellitus (T1DM) compared to those with Type 2 Diabetes Mellitus (T2DM)?

<p>Recent history of weight loss. (B)</p> Signup and view all the answers

What is a characteristic feature of insulin resistance commonly found in individuals with T2DM?

<p>Polycystic ovary syndrome. (A)</p> Signup and view all the answers

Which laboratory test result is commonly found in individuals with Type 2 Diabetes Mellitus (T2DM)?

<p>High fasting insulin levels. (A)</p> Signup and view all the answers

Which screening method for at-risk women is recommended in Galway?

<p>An oral glucose tolerance test at 24-28 weeks gestation (D)</p> Signup and view all the answers

What is a noted disadvantage of the 2-hour OGTT for pregnant women?

<p>Many women may experience mental stress from a diagnosis of GDM (B)</p> Signup and view all the answers

Which clinical feature is most common at the presentation of Type 1 Diabetes Mellitus?

<p>Polyuria and polydipsia (D)</p> Signup and view all the answers

What is the fasting glucose threshold that suggests impaired fasting glycaemia?

<p>5.6-7.0 mmol/l (B)</p> Signup and view all the answers

Which antibody is particularly detectable in children with Type 1 Diabetes Mellitus?

<p>Insulin antibodies (D)</p> Signup and view all the answers

Which risk factor significantly contributes to the development of Type 2 Diabetes Mellitus?

<p>Inherited traits (D)</p> Signup and view all the answers

At what age does the peak presentation for Type 1 Diabetes Mellitus typically occur?

<p>Around puberty (D)</p> Signup and view all the answers

What is the consequence of having an HbA1c level that climbs from 34 to 48 mmol/mol?

<p>A markedly increased risk of Type 2 Diabetes Mellitus (D)</p> Signup and view all the answers

Which of the following is a typical glucose level at diagnosis for patients with Type 1 Diabetes Mellitus?

<p>15-30 mmol/L (D)</p> Signup and view all the answers

Which ethnic group has the highest risk for developing Type 2 Diabetes Mellitus?

<p>Asians (B)</p> Signup and view all the answers

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