Therapy 1 Diabetes Mellitus Dysfunctions

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Questions and Answers

What is the main characteristic of diabetes mellitus?

  • Hyperglycemia (correct)
  • Excessive insulin secretion
  • Insulin resistance
  • Inadequate glucagon secretion

Which factor contributes to diabetes mellitus by leading to high blood sugar levels?

  • Resistance to insulin action (correct)
  • Low carbohydrate intake
  • Adequate insulin secretion
  • Appropriate glucagon secretion

What is the impact of inadequate insulin secretion in diabetes mellitus?

  • Normal blood sugar levels
  • High blood sugar levels (correct)
  • Low blood sugar levels
  • Increased insulin sensitivity

What is the role of insulin resistance in type 2 diabetes?

<p>Elevated hepatic glucose production (D)</p> Signup and view all the answers

What is the significance of the reciprocal relationship between alpha and beta cells in type 2 diabetes?

<p>It results in hyperglycemia (A)</p> Signup and view all the answers

What is the impact of elevated fasting plasma concentrations of certain amino acids on the risk of future diabetes?

<p>Increased risk of future diabetes (A)</p> Signup and view all the answers

Elevated levels of free fatty acids and proinflammatory cytokines contribute to insulin resistance in type 2 diabetes.

<p>True (A)</p> Signup and view all the answers

Hyperglucagonemia plays a role in the development of hyperglycemia in type 2 diabetes.

<p>True (A)</p> Signup and view all the answers

Elevated fasting plasma concentrations of certain amino acids are not associated with an increased risk of future diabetes.

<p>False (B)</p> Signup and view all the answers

How can patients with type 1 diabetes be differentiated from those with type 2 disease?

<p>Patients with type 1 diabetes are lean, insulin-dependent since childhood, or have a history of diabetic ketoacidosis. (A)</p> Signup and view all the answers

What is suggestive of type 2 diabetes in a patient who has had diabetes for more than 12 years?

<p>Fasting C peptide level of more than 1 ng/dL (D)</p> Signup and view all the answers

What is a key characteristic of patients with type 2 diabetes?

<p>Obesity and acanthosis nigricans (C)</p> Signup and view all the answers

Which genetic variant is associated with increased adiposity and insulin resistance?

<p>IGF2BP2 (D)</p> Signup and view all the answers

What may differentiate patients with type 1 from those with type 2 diabetes?

<p>Low insulin levels and normal C peptide levels (A)</p> Signup and view all the answers

What can be used to differentiate between patients with type 1 and type 2 diabetes?

<p>Elevated fasting plasma concentrations of certain amino acids (B)</p> Signup and view all the answers

What is the most common cause of secondary diabetes?

<p>Diseases of the pancreas that destroy the pancreatic beta cells (A)</p> Signup and view all the answers

Which condition can cause peripheral insulin resistance leading to secondary diabetes?

<p>Acromegaly (D)</p> Signup and view all the answers

Which illness can interfere with insulin secretion and contribute to secondary diabetes?

<p>Cushing syndrome (B)</p> Signup and view all the answers

Which medication can contribute to the development of secondary diabetes?

<p>Phenytoin (B)</p> Signup and view all the answers

What is the main defining characteristic of gestational diabetes mellitus?

<p>Decreased insulin sensitivity as pregnancy progresses (D)</p> Signup and view all the answers

What role does maternal insulin secretion play in the development of gestational diabetes mellitus?

<p>Increases to counteract decreasing insulin sensitivity (B)</p> Signup and view all the answers

What is the impact of glucose intolerance with onset during pregnancy?

<p>Gestational diabetes mellitus (D)</p> Signup and view all the answers

What are the defined fasting blood glucose levels for prediabetes?

<p>100-125 mg/dL (C)</p> Signup and view all the answers

What is the 2-hour post oral glucose tolerance test (post OGTT) glucose level for prediabetes?

<p>160-200 mg/dL (D)</p> Signup and view all the answers

What is the increased risk associated with prediabetes?

<p>Macrovascular and microvascular disease (A)</p> Signup and view all the answers

What is the main determinant of microvascular and metabolic complications in diabetes?

<p>Hyperglycemia (D)</p> Signup and view all the answers

What lipid abnormality is related in part to insulin resistance in people with diabetes?

<p>Elevated levels of small, dense low density lipoprotein (LDL) cholesterol particles (A)</p> Signup and view all the answers

What is involved in the thrombotic abnormalities related to cardiovascular risk in people with diabetes?

<p>Elevated fibrinogen (C)</p> Signup and view all the answers

What is associated with increased lipid accumulation in the liver and smooth muscle due to insulin resistance?

<p>Elevated levels of small, dense low density lipoprotein (LDL) cholesterol particles (B)</p> Signup and view all the answers

What contributes to insulin resistance in type 2 diabetes?

<p>Elevated levels of free fatty acids and proinflammatory cytokines (D)</p> Signup and view all the answers

What is the main contributor to hyperglycemia in type 2 diabetes?

<p>Excessive or inappropriate glucagon secretion (C)</p> Signup and view all the answers

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