Diabetes Management Quiz
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Questions and Answers

What is the primary medication prescribed for managing blood glucose levels?

  • Metformin (correct)
  • Thiazolidinediones
  • Sulfonylureas
  • DPP-4 inhibitors
  • What lifestyle changes are recommended to improve blood glucose levels?

  • Increase sugary snacks and decrease active lifestyle
  • Promote a healthier diet and exercise regularly (correct)
  • Only rely on medication without any dietary changes
  • Increase intake of fried foods and reduce exercise
  • If blood glucose levels do not improve after 3 months, what is the next step?

  • Increase the dose of Metformin
  • Switch to insulin therapy exclusively
  • Eliminate all medications
  • Combine Metformin with DPP-4 inhibitors (correct)
  • What does an A1c level indicate in diabetes management?

    <p>The average blood glucose over the past 2-3 months (A)</p> Signup and view all the answers

    What should be assessed if blood glucose levels stabilize after lifestyle improvements?

    <p>Determine the minimum dose of Metformin needed (C)</p> Signup and view all the answers

    What is the recommended initial dosage of Metformin for treating type 2 diabetes?

    <p>500 mg twice daily or 850 mg once daily (A)</p> Signup and view all the answers

    Which of the following is NOT a lifestyle intervention recommended for managing diabetes?

    <p>Lipid-lowering drug therapy (B)</p> Signup and view all the answers

    Which LDL cholesterol level is preferred for patients with cardiovascular disease?

    <p>LDL &lt; 70 mg/dL (A)</p> Signup and view all the answers

    What is the glycemic goal for HbA1c in most non-pregnant adults with diabetes?

    <p>HbA1c &lt; 7% (D)</p> Signup and view all the answers

    When should insulin therapy be initiated in diabetes management?

    <p>If HbA1c is greater than 10% (A)</p> Signup and view all the answers

    Which class of medication is recommended for primary prevention in diabetes patients with increased cardiovascular risk?

    <p>Antiplatelet medications (B)</p> Signup and view all the answers

    What is the primary function of Metformin in diabetes management?

    <p>Slowing glucose release from the liver (C)</p> Signup and view all the answers

    Which of the following medications is appropriate for diabetes patients with a known aspirin allergy?

    <p>Clopidogrel (A)</p> Signup and view all the answers

    In which situation should aspirin not be recommended?

    <p>Patients with low cardiovascular risk (A)</p> Signup and view all the answers

    What alternative medication may be prescribed for gestational diabetes if insulin therapy is not preferred?

    <p>Metformin (A)</p> Signup and view all the answers

    Which antihypertensive classes are recommended for managing hypertension in diabetes patients?

    <p>ACE inhibitors and ARBs (C)</p> Signup and view all the answers

    What is a key characteristic of Metformin regarding blood glucose levels?

    <p>It does not cause hypoglycemia by itself (B)</p> Signup and view all the answers

    Which class of medications is NOT categorized under oral antidiabetic agents for diabetes management?

    <p>ACE inhibitors (A)</p> Signup and view all the answers

    What is the primary reason for the necessity of insulin in patients with Type 1 diabetes?

    <p>There is an autoimmune reaction damaging insulin-producing cells. (B)</p> Signup and view all the answers

    Which insulin type has a rapid onset and is typically administered before meals?

    <p>Aspart, Lispro, Glulisine (Rapid-acting Insulin) (B)</p> Signup and view all the answers

    What is the recommended time to administer Regular Insulin relative to meals?

    <p>30-60 minutes before eating (C)</p> Signup and view all the answers

    What characterizes Glargine (Ultra-long-acting Insulin) in terms of its insulin action?

    <p>Provides baseline insulin coverage lasting up to 24 hours or more. (B)</p> Signup and view all the answers

    What distinguishes Type 2 diabetes from Type 1 diabetes in terms of insulin usage?

    <p>Insulin is produced but not utilized effectively. (B)</p> Signup and view all the answers

    What is a potential benefit of using insulin analogs for diabetes management?

    <p>They can reduce the risk of hypoglycemia. (B)</p> Signup and view all the answers

    Which insulin type has an onset time of 2-4 hours and is often used for longer coverage?

    <p>NPH (Intermediate-acting Insulin) (D)</p> Signup and view all the answers

    What role does Pramlintide serve in addition to insulin in diabetes treatment?

    <p>It acts as a synthetic analog of human amylin. (B)</p> Signup and view all the answers

    What is the primary role of pramlintide in individuals with type 1 diabetes?

    <p>Slows gastric emptying and promotes satiety (D)</p> Signup and view all the answers

    In which age group are statins more frequently recommended for diabetic patients?

    <p>41 years and older (A)</p> Signup and view all the answers

    What should be given to a conscious individual experiencing hypoglycemia?

    <p>Glucose 15-20 g orally (D)</p> Signup and view all the answers

    When might a pancreas or islet transplant be considered for patients with diabetes?

    <p>When traditional approaches to glycemic control fail (A)</p> Signup and view all the answers

    What role does metformin play when added as an adjuvant in type 1 diabetes treatment?

    <p>May reduce insulin dose but glycemic control effect is unclear (C)</p> Signup and view all the answers

    Which medication is recommended for primary prevention of cardiovascular disease in patients with diabetes?

    <p>Aspirin 75 mg/day (A)</p> Signup and view all the answers

    Which type of antihypertensive medication is suggested for diabetic patients?

    <p>ACE inhibitors or ARBs (C)</p> Signup and view all the answers

    What is the recommended action for individuals at significant risk of severe hypoglycemia?

    <p>Prescribe glucagon and train caregivers on its use (D)</p> Signup and view all the answers

    What is the primary mechanism of action for thiazolidinediones in diabetes management?

    <p>Decrease insulin resistance and hepatic glucose production (B)</p> Signup and view all the answers

    Which of the following is NOT a sulfonylurea used to increase insulin secretion?

    <p>Miglitol (A)</p> Signup and view all the answers

    What is the role of alpha-glucosidase inhibitors in managing blood glucose levels?

    <p>Slow the absorption of carbohydrates in the intestines (B)</p> Signup and view all the answers

    What effect do SGLT-2 inhibitors have on glucose levels?

    <p>Inhibit glucose reabsorption in the kidneys (C)</p> Signup and view all the answers

    What is the primary function of Dipeptidyl Peptidase-4 (DPP-4) inhibitors?

    <p>Prolong the action of incretins like GLP-1 (C)</p> Signup and view all the answers

    In a patient with obesity class 1 and an A1C level between 8 and 9.5%, what initial treatment strategy should be considered?

    <p>Lifestyle changes with potential oral medication (C)</p> Signup and view all the answers

    Which of the following is a significant cardiovascular risk factor along with obesity in diabetes management?

    <p>Low HDL cholesterol levels (A)</p> Signup and view all the answers

    What is the main advantage of using GLP-1 mimetics like Exenatide and Liraglutide?

    <p>They promote insulin secretion in response to meals (C)</p> Signup and view all the answers

    Flashcards

    Type 1 Diabetes

    Type 1 diabetes occurs when the body's immune system mistakenly attacks and destroys the insulin-producing cells in the pancreas, preventing the body from making its own insulin.

    Type 2 Diabetes

    Type 2 diabetes develops when the body either doesn't produce enough insulin or the cells become resistant to the insulin produced, leading to high blood sugar levels.

    Gestational Diabetes

    Gestational diabetes is a temporary condition that develops during pregnancy. It occurs when the body can't produce enough insulin to manage the extra sugars in the blood during pregnancy.

    Insulin

    Insulin is a hormone produced by the pancreas that allows the body to use glucose (sugar) for energy. In type 1 diabetes, the body does not produce insulin, so patients have to take it externally.

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    Rapid-acting Insulin

    Rapid-acting insulin, like Aspart, Lispro, and Glulisine, starts working quickly, peaks within 1-2 hours, and lasts about 4 hours. It's typically taken before meals to manage blood sugar spikes after eating.

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    Regular Insulin

    Regular insulin is a short-acting insulin, it starts working in 30 minutes to 1 hour, peaks in 2-3 hours, and lasts for up to 6 hours. It's used to control blood sugar levels around meal times.

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    NPH Insulin

    NPH insulin is an intermediate-acting insulin, it starts working 2-4 hours after injection, peaks between 4-12 hours, and lasts for around 12-18 hours. It's used for longer coverage, often combined with rapid or regular insulin.

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    Long-acting Insulin

    Detemir and Glargine are long-acting insulins. They start working gradually, have no pronounced peak, and provide sustained insulin levels, lasting up to 24 hours or more. They provide baseline insulin coverage throughout the day.

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    What is the function of Pramlintide?

    A medication that slows down the stomach's emptying process, leading to a feeling of fullness and helping to prevent blood sugar spikes after meals.

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    How does Metformin affect type 1 diabetes?

    Metformin is a medication that helps the body utilize insulin more effectively. In type 1 diabetes, it might reduce the insulin dose needed, but its impact on blood sugar control is still being studied.

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    Why are statins often used in type 1 diabetes?

    Statins are a type of lipid-lowering drug commonly recommended for diabetic patients over 40 due to their increased risk of heart disease. They are also sometimes used in younger patients.

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    What types of blood pressure medications are often used for type 1 diabetes?

    Angiotensin-converting enzyme (ACE) inhibitors and Angiotensin receptor blockers (ARBs) are two types of blood pressure medications that are frequently prescribed for individuals with diabetes.

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    When is Aspirin often recommended for type 1 diabetes?

    Aspirin is often recommended as a primary prevention strategy for type 1 diabetic individuals with an increased risk of heart disease, particularly those who are 50 years or older and have at least one additional risk factor.

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    What is a potential treatment option for type 1 diabetes with uncontrolled blood sugar levels?

    Pancreas or islet transplantation may be considered for individuals with type 1 diabetes who have unstable blood sugar control despite conventional treatments.

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    How do you treat hypoglycemia in a conscious person with type 1 diabetes?

    If a person with type 1 diabetes is conscious and able to swallow, 15-20 grams of glucose, in any form of carbohydrate, should be administered orally. If they are unconscious or unable to swallow, 25 grams of glucose should be given intravenously.

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    What medication should individuals at risk of severe hypoglycemia have on hand?

    All individuals with type 1 diabetes at significant risk of severe hypoglycemia should be prescribed glucagon, and their caregivers or family members should be trained on its use.

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    What is the first-line drug for Type 2 Diabetes?

    Metformin is the first-line treatment for type 2 diabetes. It helps the body use insulin more effectively and reduces glucose production in the liver.

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    When is a second drug added to treat Type 2 Diabetes?

    If glycemic goals are not met on metformin alone, a second drug is added. This could be an oral antidiabetic agent or an injectable medication.

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    When is a third drug added to treat Type 2 Diabetes?

    If glycemic goals are not met on a 2-drug combination, a third drug is added.

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    What are oral antidiabetic agents?

    Oral antidiabetic agents are medications taken by mouth to help manage blood sugar levels. They work in different ways, such as increasing insulin production, improving insulin sensitivity, or slowing down glucose absorption.

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    What are injectable antidiabetic agents?

    Injectable antidiabetic agents are medications that are injected to help manage blood sugar levels. They work by mimicking the body's natural insulin, helping the body use glucose for energy.

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    What are A1c levels?

    A1c levels, also known as HbA1c, are a measure of average blood glucose over the past 2-3 months in individuals with diabetes. They provide a crucial indicator for evaluating the effectiveness of diabetes management strategies and adjusting treatments accordingly.

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    What is the initial treatment for type 2 diabetes?

    Metformin is the initial medication commonly recommended for treating type 2 diabetes. It aids in improving the body's utilization of insulin and reduces glucose production in the liver.

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    What happens if blood sugar control goals are not achieved?

    When lifestyle changes and initial medications fail to achieve the desired blood sugar control goals within three months, a second medication is typically added to the treatment plan. This can involve an oral antidiabetic agent or an injectable medication, depending on individual needs and preferences.

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    How can lifestyle changes help manage diabetes?

    Individuals with diabetes should aim to reduce their consumption of fried foods and adopt a healthier diet rich in fruits, vegetables, and whole grains. Regular physical activity, such as exercise or sports, is also essential for maintaining optimal blood sugar control.

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    What is the approach to managing diabetes effectively?

    Lifestyle modifications and medication adjustment are crucial for managing diabetes. A1c levels are used to monitor blood sugar levels and adjust treatment plans accordingly, sometimes involving a combination of oral and injectable medications.

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    What is metformin and how does it work?

    Metformin is a medication used to treat type 2 diabetes. It slows down glucose release from the liver and helps cells use glucose. Metformin can also lower fat and cholesterol levels and doesn't cause hypoglycemia by itself.

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    ACE inhibitors and ARBs: what do they do?

    ACE inhibitors and ARBs are medications used to lower blood pressure by blocking the renin-angiotensin system, which narrows blood vessels and raises pressure.

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    Aspirin and clopidogrel: Why are they given to people with diabetes?

    Aspirin (low dose) and clopidogrel are medications used to prevent blood clots and reduce heart disease risk in people with diabetes. Aspirin is the preferred choice for most patients, while clopidogrel is an alternative for those allergic to aspirin.

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    What are the preferred treatments for gestational diabetes?

    Insulin therapy is the preferred treatment for gestational diabetes, a temporary condition during pregnancy. Metformin can also sometimes be used safely during pregnancy in gestational diabetes.

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    Why is aspirin important for patients with diabetes?

    Patients with diabetes are at increased cardiovascular risk, making it crucial to consider aspirin as a preventive measure. This is especially important for men over 50 and women over 60 with additional risk factors. Aspirin is also recommended for patients with a history of cardiovascular disease as a secondary prevention strategy.

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    Who should take aspirin for diabetes prevention?

    Most patients with diabetes, particularly those with increased cardiovascular risk, benefit from preventive measures with aspirin. However, for patients with low cardiovascular risk, aspirin may not be necessary.

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    Thiazolidinediones (Glitazones)

    A class of medications that work by decreasing insulin resistance in the liver and peripheral tissues, increasing glucose uptake, and reducing hepatic glucose production.

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    Sulfonylureas

    A class of drugs that stimulate insulin secretion from the pancreas and potentially increase tissue sensitivity to insulin.

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    Alpha-glucosidase Inhibitors

    A class of medications that work by slowing down the digestion of carbohydrates in the small intestine, leading to a slower and lower rise in blood glucose levels after meals.

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    SGLT-2 Inhibitor

    A type of medication that works by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine.

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    Incretins (GLP-1) and Dipeptidyl Peptidase IV (DPP-4) Inhibitors (Gliptins)

    This class of drugs includes GLP-1 mimetics and DPP-4 inhibitors. GLP-1 mimetics mimic the action of GLP-1, a hormone that stimulates insulin secretion and slows gastric emptying. DPP-4 inhibitors block the breakdown of GLP-1.

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    Metformin

    A medication often used for type 2 diabetes that works by reducing glucose production by the liver and increasing insulin sensitivity in the tissues.

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    Second Drug

    This class of medication is often used to help manage type 2 diabetes by increasing insulin secretion from the pancreas and enhancing insulin sensitivity in the cells.

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    Third Drug

    This class of medication is often used to help manage type 2 diabetes by targeting multiple pathways involved in glucose metabolism.

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    Study Notes

    Workshop 6: Pharmacology of Diabetes

    • Workshop presented by Professor Vittoria Carrabs PhD, 3rd Medicine, Aa 2024-25
    • Focuses on the pharmacology of diabetes, including types 1 and 2.

    Diabetes Types 1 and 2

    • Diabetes tipo 1: Caused by an autoimmune reaction destroying the islets of Langerhans (beta cells), preventing insulin production. Patients require daily insulin to survive.
    • Type 2 diabetes: Body does not properly use insulin and cannot maintain normal blood sugar levels.

    Gestational Diabetes

    • A type of diabetes that develops during pregnancy.
    • Insulin therapy and metformin are preferred for managing gestational diabetes.

    Insulins (Types)

    • Rapid-acting: Aspart, lispro, glulisine; rapid onset (1-2 hours), peak (2-3 hours), duration (4 hours). Taken before meals to manage post-prandial blood sugar spikes.
    • Short-acting: Regular insulin; onset (30 minutes-1 hour), peak (2-3 hours), duration (up to 6 hours); used to control blood sugar levels around meal times (given 30-60 minutes before eating)
    • Intermediate-acting: NPH; onset (2-4 hours), peak (4-12 hours), duration (12-18 hours); used for longer coverage, often combined with rapid or regular insulin.
    • Long-acting: Detemir; gradual onset (around 2 hours), no pronounced peak, duration (up to 24 hours); provides stable insulin levels for longer periods, suitable for background coverage.
    • Ultra-long-acting: Glargine; very steady effect, no significant peak, duration (up to 24 hours or more); ideal for baseline insulin coverage for an entire day.

    Adjuvant Glucose-Lowering Medications

    • Pramlintide: A synthetic analog of human amylin; co-secreted with insulin. Associated with improved glycemic control in adults with type 1 diabetes and slows gastric emptying and promotes satiety. Administered subcutaneously before each major meal.
    • Metformin: May reduce insulin dose in type 1 diabetes patients, but its effect on glycemic control is unclear. Suitable for initial treatment strategy for Type 2.
    • Lipid-lowering drug therapy: Effective for primary and secondary prevention of major coronary events. Statins are frequently recommended for patients over 40.
    • Antihypertensive medications: Angiotensin-converting enzyme (ACE) inhibitors or Angiotensin receptor blockers (ARB) commonly prescribed.

    Antiplatelet Medications

    • Aspirin 75 mg/day: Recommended as a primary prevention strategy for patients with diabetes at increased risk of atherosclerotic cardiovascular disease (men >50 or women >50 with additional risk factors).

    Diabetes 1: Pancreas or Islet Transplant

    • May be considered for patients with uncontrolled glucose despite traditional methods.

    Diabetes 1: Hypoglycemia

    • Treatment: 15-20 g glucose orally (any carbohydrate) to conscious individuals. 25 g intravenous (IV) glucose for unconscious patients or those unable to consume orally.
    • Glucagon: Prescribe glucagon for individuals at risk of severe hypoglycemia and instruct caregivers or family members on its use.

    Diabetes 2: Lifestyle Interventions

    • Dietary management: Individualized medical nutrition therapy (preferably by a registered dietitian)
    • Physical activity: At least 150 minutes per week.
    • Diabetes self-management education (DSME).
    • Diabetes psychological counseling.
    • Lipid-lowering drug therapy.
    • Weight loss.
    • Medications

    Diabetes 2: Treatment Overview

    • Glycemic goals: HbA1c < 7% in most non-pregnant adults and < 6% in pregnancy.
    • Lipid goals: Low-density lipoprotein (LDL) cholesterol < 100 mg/dL (2.6 mmol/L). Consider LDL < 70 mg/dL (1.8 mmol/L) if cardiovascular disease is also present.
    • Blood pressure goals: Vary across guidelines, but typically range from < 130/80 mmHg to < 140/90 mmHg.

    Diabetes 2: Medications

    • Metformin: First-line drug for type 2 diabetes. Initial doses are 500 mg twice daily or 850 mg once daily, increasing weekly by increments. Maximum dose is 1 g twice daily or 850 mg three times daily. May reduce insulin dose and have a positive impact on lipid metabolism.
    • Add second and third drug if glycemic goals are not met on maximal tolerated dose of Metformin monotherapy.
    • Include other oral antidiabetic agents and injectable antidiabetic agents.
    • Additional therapies for other comorbidities (antihypertensives, antiplatelets).

    Pregnant Women

    • Insulin therapy and metformin: Preferred medications for gestational diabetes.

    Diabetes 2: Oral Treatment: Metformin (Biguanide)

    • Slows glucose release by the liver and helps cells use glucose.
    • May also lower blood fat and cholesterol, and will not cause hypoglycemia on its own.

    Thiazolidinediones (Glitazones):

    • Decrease insulin resistance in peripheral tissues and the liver.
    • Increase glucose uptake and decrease hepatic glucose production.
    • Pioglitazone one such example.

    Sulfonylureas:

    • Increase insulin secretion by the pancreas and may increase tissue sensitivity to insulin.
    • Examples include glimepiride, glipizide, and glyburide.

    Alpha-Glucosidase Inhibitors:

    • Slow and lower the rise of blood glucose after meals by altering intestinal glucose absorption.
    • Examples include miglitol, acarbose, and voglibose.

    SGLT-2 Inhibitor: Dapagliflozin:

    • Inhibits sodium-glucose cotransporter 2 (SGLT2), increasing glucose excretion.

    Incretins (GLP-1) and Dipeptidyl Peptidase IV (DPP-4) Inhibitors (Gliptins):

    • GLP-1 Mimics (exenatide and liraglutide) are injectables, transcribed from the same gene that codes for glucagon and secreted by cells in response to food stimuli.
    • DPP-4 Inhibitors(sitagliptin and vildagliptin) inhibit the enzyme that hydrolyzes incretin GLP-1.

    Clinical Cases

    • Includes patient demographics, medical history, lifestyle factors, current medications, and initial blood glucose monitoring data. Information is provided for scenarios that help identify the best treatment path for diabetes.

    Information to solve cases:

    • Charts, tables and other details provided to support diabetes case analysis.
      • Includes details such as BMI, weight status, Blood glucose ranges, blood pressure, cholesterol, and other pertinent information.

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    Description

    Test your knowledge on the management of diabetes, including medication, lifestyle changes, and monitoring techniques. This quiz covers critical information related to blood glucose levels, A1c targets, and diabetes interventions that can enhance patient outcomes.

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