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Questions and Answers

What defines an antibiotic in modern terminology?

  • A substance produced by microorganisms or chemically synthesized that inhibits the growth of other microorganisms. (correct)
  • A disinfectant that can be safely used in systemic infections.
  • A substance produced by mammals that kills bacteria.
  • Any substance that can inhibit the growth of all microorganisms.

What is the primary difference between bactericidal and bacteriostatic antibiotics?

  • Bactericidal antibiotics inhibit growth while bacteriostatic antibiotics kill bacteria.
  • Bactericidal antibiotics are broad spectrum while bacteriostatic antibiotics are narrow spectrum.
  • There is no difference; both terms can be used interchangeably.
  • Bactericidal antibiotics kill bacteria, while bacteriostatic antibiotics inhibit their growth. (correct)

Which of the following statements about antibiotics is true?

  • Antibiotics can be used safely at any concentration without risk to human cells.
  • All antibiotics are equally toxic to mammalian cells as they are to microorganisms.
  • The only use of antibiotics is to disinfect surfaces before surgical procedures.
  • Most antibiotics have a high therapeutic index and selectively target microbial cells. (correct)

Which method is NOT one of the primary ways antibiotics exert their effects?

<p>Promotion of cell division in bacteria. (B)</p> Signup and view all the answers

How are antibiotics classified according to their spectrum of activity?

<p>Broad spectrum and narrow spectrum. (D)</p> Signup and view all the answers

Which of the following is a characteristic of synthetic anti-infective agents?

<p>They can be produced partly by chemical synthesis. (A)</p> Signup and view all the answers

What is a potential disadvantage of disinfectants compared to antibiotics?

<p>Disinfectants are too toxic for systemic treatment of infections. (D)</p> Signup and view all the answers

Which action is generally associated with antibiotics that belong to groups 1 and 3?

<p>Better discrimination between prokaryotic and eukaryotic cells. (D)</p> Signup and view all the answers

Which antibiotic inhibits protein chain initiation by blocking the attachment of the 50S subunit?

<p>Streptomycin (A)</p> Signup and view all the answers

What is the primary mechanism of action for aminoglycosides?

<p>Prevent the formation of the initiation complex (B)</p> Signup and view all the answers

Which antibiotics are known to prevent the elongation of the growing peptide chain?

<p>Tetracyclines (A), Macrolides (D)</p> Signup and view all the answers

What do tetracyclines primarily do during protein synthesis?

<p>Distort the shape of the 30S subunit (B)</p> Signup and view all the answers

Which of the following is NOT an effect of chloramphenicol?

<p>Prevents completion of the initiation complex (C)</p> Signup and view all the answers

Which suffix is used for aminoglycosides derived from Streptomyces?

<p>-mycin (D)</p> Signup and view all the answers

Which class of antibiotics can cause misreading of messenger RNA messages?

<p>Aminoglycosides (C)</p> Signup and view all the answers

What is the primary action of beta-lactamase inhibitors?

<p>They enhance the antibacterial actions of beta-lactam antibiotics. (C)</p> Signup and view all the answers

What is a feature of tetracyclines during the translation process?

<p>They prevent the elongation of the peptide chain (B)</p> Signup and view all the answers

Which of the following inhibitors is isolated from Streptomyces clavuligerus?

<p>Clavulanic acid (D)</p> Signup and view all the answers

Beta-lactamase inhibitors are particularly ineffective against which type of enzyme?

<p>Cephalosporinase (D)</p> Signup and view all the answers

What is the primary mechanism of action of Isoniazid?

<p>Interferes with mycolic acid synthesis. (B)</p> Signup and view all the answers

What type of antibiotic is Caspofungin classified as?

<p>Echinocandin (A)</p> Signup and view all the answers

Which antibiotics are specifically mentioned as being used in combination with clavulanic acid?

<p>Amoxicillin, ampicillin, and piperacillin (A)</p> Signup and view all the answers

What characteristic of bacterial ribosomes differentiates them from mammalian ribosomes?

<p>Bacterial ribosomes consist of 30S and 50S subunits. (C)</p> Signup and view all the answers

Which enzyme is primarily inhibited by ethambutol?

<p>Arabinotransferase (D)</p> Signup and view all the answers

What is the primary use of doxycycline as mentioned in the content?

<p>Prophylactic treatment for infection by Bacillus anthracis (D)</p> Signup and view all the answers

Which of the following tetracyclines is classified as a long-acting type?

<p>Minocycline (C)</p> Signup and view all the answers

What is tigecycline primarily used to treat?

<p>Complicated skin and skin structure infections (C)</p> Signup and view all the answers

Which of the following infections is doxycycline NOT considered the drug of choice for?

<p>Bacterial meningitis (C)</p> Signup and view all the answers

What mechanism do glycylcyclines target to remain effective against certain bacteria?

<p>Resistance due to efflux mechanisms (A)</p> Signup and view all the answers

What is the primary mechanism of action of tetracyclines?

<p>Inhibition of protein synthesis (B)</p> Signup and view all the answers

Which type of bacteria are tetracyclines generally effective against?

<p>Both Gram-positive and Gram-negative bacteria (D)</p> Signup and view all the answers

Why should tetracyclines not be used in combination with β-lactams?

<p>Tetracyclines require bacterial division to be effective (D)</p> Signup and view all the answers

What characteristic do kanamycin and neomycin share?

<p>Both are used primarily for topical applications (D)</p> Signup and view all the answers

Which property is true of tetracycline's entry into prokaryotic cells?

<p>They require a permease for active transport (A)</p> Signup and view all the answers

Which of the following therapeutic uses is NOT commonly associated with tetracyclines?

<p>Amebiasis treatment (C)</p> Signup and view all the answers

Which statement about spectinomycin is accurate?

<p>It is used mainly for drug-resistant gonorrhea (C)</p> Signup and view all the answers

Which antibiotic is considered a second-line treatment for tuberculosis?

<p>Kanamycin (C)</p> Signup and view all the answers

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