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Questions and Answers
What is the primary cause of acute bursitis, according to the provided information?
What is the primary cause of acute bursitis, according to the provided information?
What is the primary factor that differentiates Legg-Calve-Perthes disease from other childhood hip conditions?
What is the primary factor that differentiates Legg-Calve-Perthes disease from other childhood hip conditions?
Which of the following accurately describes the role of neutrophils and macrophages in the inflammatory response triggered by MSU crystals?
Which of the following accurately describes the role of neutrophils and macrophages in the inflammatory response triggered by MSU crystals?
Which of the following is NOT a clinical manifestation of gout?
Which of the following is NOT a clinical manifestation of gout?
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Which of the following BEST describes the reason why gout is more common in men than women?
Which of the following BEST describes the reason why gout is more common in men than women?
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Which of the following risk factors is MOST associated with Developmental Dysplasia of the Hip (DDH)?
Which of the following risk factors is MOST associated with Developmental Dysplasia of the Hip (DDH)?
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What is the MOST significant difference between a subluxated hip and a dislocated hip in DDH?
What is the MOST significant difference between a subluxated hip and a dislocated hip in DDH?
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Which physical finding MOST indicates a potentially developing false acetabulum in DDH?
Which physical finding MOST indicates a potentially developing false acetabulum in DDH?
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Which clinical finding is indicative of a REDUCED (not dislocated) hip in DDH, as demonstrated during the physical exam?
Which clinical finding is indicative of a REDUCED (not dislocated) hip in DDH, as demonstrated during the physical exam?
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What is the clinical significance of a positive Trendelenburg gait in a patient with DDH?
What is the clinical significance of a positive Trendelenburg gait in a patient with DDH?
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Which of the following statements BEST describes the typical presentation of pain in DDH?
Which of the following statements BEST describes the typical presentation of pain in DDH?
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What is the MOST likely outcome if the hip remains subluxed or dislocated in DDH?
What is the MOST likely outcome if the hip remains subluxed or dislocated in DDH?
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Which of the following is NOT a common physical finding associated with DDH?
Which of the following is NOT a common physical finding associated with DDH?
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Which of the following factors is LEAST likely to contribute to the development of Developmental Dysplasia of the Hip (DDH) in a newborn?
Which of the following factors is LEAST likely to contribute to the development of Developmental Dysplasia of the Hip (DDH) in a newborn?
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Which of the following conditions is associated with DDH in a significant percentage of cases?
Which of the following conditions is associated with DDH in a significant percentage of cases?
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What initiates the formation of osteoclasts during the bone remodeling cycle?
What initiates the formation of osteoclasts during the bone remodeling cycle?
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Which type of fracture involves the bone breaking into three or more pieces?
Which type of fracture involves the bone breaking into three or more pieces?
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After osteoblasts secrete matrix and become trapped, what are they called?
After osteoblasts secrete matrix and become trapped, what are they called?
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Which of the following correctly describes the characteristics of osteoclasts?
Which of the following correctly describes the characteristics of osteoclasts?
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What happens during the reabsorption phase of the remodeling cycle?
What happens during the reabsorption phase of the remodeling cycle?
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Which of the following is NOT a type of fracture classification?
Which of the following is NOT a type of fracture classification?
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Which cells are responsible for the formation of osteoblasts from precursor cells?
Which cells are responsible for the formation of osteoblasts from precursor cells?
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What is the function of enzymes during the callus formation stage of bone healing?
What is the function of enzymes during the callus formation stage of bone healing?
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Which of the following factors does NOT influence the speed of bone healing?
Which of the following factors does NOT influence the speed of bone healing?
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What characterizes malunion in bone healing?
What characterizes malunion in bone healing?
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What condition is described by the presence of a fluid-filled space resembling a joint in the fracture gap?
What condition is described by the presence of a fluid-filled space resembling a joint in the fracture gap?
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Which type of bone generally heals faster according to the healing practices?
Which type of bone generally heals faster according to the healing practices?
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What is the main outcome of the remodeling stage in bone healing?
What is the main outcome of the remodeling stage in bone healing?
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Which growth factor is NOT specifically mentioned as aiding in the healing process?
Which growth factor is NOT specifically mentioned as aiding in the healing process?
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What is the role of physical modalities in the treatment of delayed union and nonunion?
What is the role of physical modalities in the treatment of delayed union and nonunion?
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What outcome occurs due to improper reduction or immobilization of a fractured bone?
What outcome occurs due to improper reduction or immobilization of a fractured bone?
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What is the primary function of osteoblasts during callus formation?
What is the primary function of osteoblasts during callus formation?
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Which of the following best describes the procallus formation process?
Which of the following best describes the procallus formation process?
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What happens to the fracture line after four months of healing?
What happens to the fracture line after four months of healing?
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What are the potential consequences of improper reduction or immobilization of a fracture?
What are the potential consequences of improper reduction or immobilization of a fracture?
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Which of the following is NOT a manifestation of a fracture?
Which of the following is NOT a manifestation of a fracture?
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What stage follows hematoma formation in the bone healing process?
What stage follows hematoma formation in the bone healing process?
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Which statement about callus formation is accurate?
Which statement about callus formation is accurate?
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Where does callus formation initially occur after a fracture?
Where does callus formation initially occur after a fracture?
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What role do hematopoietic growth factors play in the healing of bone fractures?
What role do hematopoietic growth factors play in the healing of bone fractures?
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Flashcards
Haversian systems
Haversian systems
Bone structures that undergo destruction and formation during remodeling.
Bone-remodeling units (BMU)
Bone-remodeling units (BMU)
Groups of precursor cells that differentiate into osteoblasts and osteoclasts.
Osteoclasts
Osteoclasts
Large, multinucleated cells that absorb bone during remodeling.
Osteoblasts
Osteoblasts
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Fracture
Fracture
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Comminuted fracture
Comminuted fracture
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Open fracture
Open fracture
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Inflammatory response
Inflammatory response
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Procallus formation
Procallus formation
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Callus formation
Callus formation
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Hematoma formation
Hematoma formation
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Callus replacement and remodeling
Callus replacement and remodeling
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Malunion
Malunion
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Delayed union
Delayed union
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Closed manipulation
Closed manipulation
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Cartilage formation
Cartilage formation
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Bone Replacement
Bone Replacement
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Bone Remodeling
Bone Remodeling
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Factors affecting healing speed
Factors affecting healing speed
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Nonunion
Nonunion
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False joint
False joint
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Treatment modalities
Treatment modalities
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Acute bursitis
Acute bursitis
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Septic bursitis
Septic bursitis
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Legg-Calve-Perthes disease
Legg-Calve-Perthes disease
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Gout
Gout
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Hyperuricemia
Hyperuricemia
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Developmental Dysplasia of the Hip (DDH)
Developmental Dysplasia of the Hip (DDH)
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Asymmetry of gluteal or thigh folds
Asymmetry of gluteal or thigh folds
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Limb length discrepancy
Limb length discrepancy
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Barlow Maneuver
Barlow Maneuver
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Ortolani Maneuver
Ortolani Maneuver
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Galeazzi Sign
Galeazzi Sign
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Trendelenburg Gait
Trendelenburg Gait
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Subluxated Hip
Subluxated Hip
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Dislocated Hip
Dislocated Hip
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Acetabular Dysplasia
Acetabular Dysplasia
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Study Notes
Bone Remodeling Units
- Bone remodeling units (BMUs) are bone precursor cells that differentiate into osteoblasts and osteoclasts.
- BMUs repair microscopic injuries and maintain bone integrity.
Bone-Remodeling Phases
- Phase 1 (activation): A stimulus (hormone, drug, vitamin, physical stressor, injury) activates precursor cells to form osteoclasts, which leads to bone reabsorption. Apoptotic osteocytes guide osteoclast activity, signaling where to resorb damaged bone.
- Phase 2 (resorption): Osteoclasts, large multinucleated cells, gradually absorb bone, creating a "cutting cone" resorption cavity. Lysosomal enzymes digest bone, and osteoclasts release degraded bone products into the vascular system.
- Phase 3 (formation): Osteoblasts, small cells, lay down new secondary bone within the resorption cavity. Osteoblasts lining the cavity secrete osteoid, fostering calcium and phosphorus deposition. Subsequent layers generate a haversian canal around a blood vessel. The old haversian systems are eventually replaced by new ones. This phase takes 4-6 months in humans.
Bone-Remodelling Units (BMU)
- BMUs are composed of precursor cells that differentiate into osteoblasts and osteoclasts.
- BMUs repair micrsocopic injuries and maintain bone integrity.
Fracture Types/Descriptions
- Fracture: a break in the continuity of a bone
- Complete vs Incomplete fractures: Complete fractures go completely through the bone while incomplete fractures do not
- Closed vs Open fractures: Closed (simple) fractures don't pierce the skin; open (compound) fractures do
- Other types include: Comminuted (3+ fragments), Linear (parallel to bone axis), Oblique (slanted across bone), Spiral (twisting of bone ends), Transverse (perpendicular to bone axis), Greenstick (bending fracture that only occurs on one side; usually in children), Torus (buckling of bone), and Bowing (bending)
Typical Complete Fractures
- Closed: Skin over the bone is intact.
- Open: Skin opening exists between bone and the skin
- Comminuted: Multiple bone fragments are present
- Linear: Fracture line is parallel to the bone's axis.
Typical Incomplete Fractures
- Greenstick: Fracture on one side only (common in children)
- Torus: Buckling of the bone cortex
- Bowing: Bending of the bone
Fracture Healing Stages
- Hematoma formation: Formation of blood clot within the injured area
- Procallus formation: Formation of fibrovascular tissue and collagen fibers from fibroblasts and osteoblasts
- Callus formation: Woven bone forms between the broken ends
- Callus replacement: Existing callus is replaced with lamellar bone.
- Remodeling: Bone remodeling occurs to shape and form the bone similar to its original structure.
Osteoarthritis (OA)
- OA is a noninflammatory joint disease.
- Characterized by local areas of damage and loss of articular cartilage, sclerosis of bone beneath the cartilage, osteophyte formation, and variable degrees of mild synovitis and joint capsule thickening.
Rheumatoid Arthritis (RA)
- RA is a systemic inflammatory autoimmune disease primarily affecting the joints.
- Characterized by inflammation in the synovial membrane of the joint, leading to cartilage and bone destruction.
- Systemic signs of inflammation are often present (e.g., fever, leukocytosis, malaise, anorexia, and hyperfibrinogenemia).
- Pathogenesis involves T cell activation, cytokine release, inflammatory cell recruitment, and damage to cartilage and bone.
Gout
- Gout is a metabolic disorder characterized by elevated serum uric acid levels.
- The increased uric acid levels lead to the formation of monosodium urate crystals, which deposit in joints and other tissues, causing inflammation and pain.
Legg-Calve-Perthes Disease (LCP)
- LCP is a self-limited disease of the hip, usually affecting children between the ages of 3 and 10 years.
- Primarily characterized by avascular necrosis (death of bone tissue due to inadequate blood supply) of the femoral head.
Ankylosing Spondylitis (AS)
- AS is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints.
- Causes stiffening and/or fusion of the spine.
- Often associated with HLA-B27.
- Early symptoms include low back pain and stiffness, typically worse after rest.
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Description
Test your knowledge on Developmental Dysplasia of the Hip (DDH) and conditions like acute bursitis and gout. This quiz covers various clinical manifestations, risk factors, and important physical findings related to hip conditions. Challenge yourself to see how well you understand these topics.