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Questions and Answers
What is the name of the first set of excretory organs that develops during embryogenesis?
What is the name of the first set of excretory organs that develops during embryogenesis?
Which of the following structures forms the collecting system of the kidneys?
Which of the following structures forms the collecting system of the kidneys?
What is the name of the excretory units that form in the mesonephros?
What is the name of the excretory units that form in the mesonephros?
At what stage of development does the metanephros, the permanent kidney, appear?
At what stage of development does the metanephros, the permanent kidney, appear?
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Which of the following is NOT a common congenital disorder of the urinary tract?
Which of the following is NOT a common congenital disorder of the urinary tract?
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The mesonephric duct persists in males to form which of the following structures?
The mesonephric duct persists in males to form which of the following structures?
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What is the name of the structure that forms the primitive renal pelvis?
What is the name of the structure that forms the primitive renal pelvis?
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Which of the following statements about the pronephros is TRUE?
Which of the following statements about the pronephros is TRUE?
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What is the typical incidence of bilateral renal agenesis?
What is the typical incidence of bilateral renal agenesis?
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Which of the following is NOT a characteristic of Potter sequence?
Which of the following is NOT a characteristic of Potter sequence?
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Which type of polycystic kidney disease is more common?
Which type of polycystic kidney disease is more common?
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In which type of polycystic kidney disease do cysts form from all segments of the nephron?
In which type of polycystic kidney disease do cysts form from all segments of the nephron?
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What is the typical age of onset of renal failure in autosomal recessive polycystic kidney disease?
What is the typical age of onset of renal failure in autosomal recessive polycystic kidney disease?
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Which of the following contributes to the ascent of the kidney during development?
Which of the following contributes to the ascent of the kidney during development?
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What is the typical position of the renal pelvis after the kidney's 90° rotation?
What is the typical position of the renal pelvis after the kidney's 90° rotation?
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Which of the following is a possible location for an ectopic ureter?
Which of the following is a possible location for an ectopic ureter?
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Regarding the development of the urethra, which statement is TRUE?
Regarding the development of the urethra, which statement is TRUE?
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What is the primary reason for the development of the ejaculatory ducts in males?
What is the primary reason for the development of the ejaculatory ducts in males?
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Which of the following developmental abnormalities results in a cystic dilation of a portion of the allantois?
Which of the following developmental abnormalities results in a cystic dilation of a portion of the allantois?
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What is the primary cause of exstrophy of the bladder?
What is the primary cause of exstrophy of the bladder?
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Which of the following is NOT a consequence of the ascent of the kidneys during development?
Which of the following is NOT a consequence of the ascent of the kidneys during development?
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During fetal development, what is the primary function of the placenta?
During fetal development, what is the primary function of the placenta?
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What anatomical structure forms from the obliterated allantois?
What anatomical structure forms from the obliterated allantois?
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What is a pelvic kidney?
What is a pelvic kidney?
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The ureters initially develop as outgrowths from which structure?
The ureters initially develop as outgrowths from which structure?
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Which of the following structures is NOT derived from the urogenital sinus?
Which of the following structures is NOT derived from the urogenital sinus?
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What specific structure prevents a horseshoe kidney from ascending to its normal position in the abdomen?
What specific structure prevents a horseshoe kidney from ascending to its normal position in the abdomen?
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At what gestational age does the definitive kidney become functional?
At what gestational age does the definitive kidney become functional?
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What is the primary reason for the difference in the phallic part of the urogenital sinus between males and females?
What is the primary reason for the difference in the phallic part of the urogenital sinus between males and females?
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What is the primary source of formation for collecting tubules?
What is the primary source of formation for collecting tubules?
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Which of the following structures forms from the second order tubules?
Which of the following structures forms from the second order tubules?
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At what stage of development do the glomeruli form?
At what stage of development do the glomeruli form?
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What is the role of the metanephric tissue cap cells?
What is the role of the metanephric tissue cap cells?
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Which of these is a direct consequence of the ureteric bud failing to branch?
Which of these is a direct consequence of the ureteric bud failing to branch?
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What is the primary reason for the lobulation of the kidney at birth?
What is the primary reason for the lobulation of the kidney at birth?
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Which of the following is a CORRECT statement regarding nephron formation?
Which of the following is a CORRECT statement regarding nephron formation?
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What is the primary function of the Bowman's capsule?
What is the primary function of the Bowman's capsule?
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Flashcards
Pronephros
Pronephros
The first set of excretory organs that is rudimentary and nonfunctional.
Mesonephros
Mesonephros
The second set of excretory organs that may function briefly during early fetal development.
Metanephros
Metanephros
The definitive kidney that forms the permanent kidney by the fifth week of development.
Nephrotomes
Nephrotomes
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Ureteric bud
Ureteric bud
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Renal pelvis
Renal pelvis
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Congenital anomalies
Congenital anomalies
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Position changes of kidneys
Position changes of kidneys
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Nephron
Nephron
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Bowman's Capsule
Bowman's Capsule
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Collecting Tubules
Collecting Tubules
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Glomerulus
Glomerulus
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Multicystic Dysplastic Kidney
Multicystic Dysplastic Kidney
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Proximal Convoluted Tubule
Proximal Convoluted Tubule
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Renal Pyramid
Renal Pyramid
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Renal Agenesis
Renal Agenesis
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Potter Sequence
Potter Sequence
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Congenital Polycystic Kidney Disease
Congenital Polycystic Kidney Disease
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Autosomal Recessive PKD
Autosomal Recessive PKD
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Autosomal Dominant PKD
Autosomal Dominant PKD
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Ureter Duplication
Ureter Duplication
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Kidney Migration
Kidney Migration
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Arterial Supply During Kidney Ascension
Arterial Supply During Kidney Ascension
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Urethra Development
Urethra Development
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Prostatic Urethra in Males
Prostatic Urethra in Males
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Urachal Fistula
Urachal Fistula
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Exstrophy of the Bladder
Exstrophy of the Bladder
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Urachal Cyst
Urachal Cyst
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Pelvic Kidney
Pelvic Kidney
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Horseshoe Kidney
Horseshoe Kidney
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Accessory Renal Arteries
Accessory Renal Arteries
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Function of the Kidney in Fetus
Function of the Kidney in Fetus
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Cloaca Division
Cloaca Division
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Urogenital Sinus
Urogenital Sinus
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Urachus
Urachus
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Study Notes
Development of the Urinary System
- The urinary and genital systems develop from a common mesodermal ridge (intermediate mesoderm).
- The pronephros, the first excretory organ, is rudimentary and nonfunctional.
- The mesonephros, the second excretory organ, may function briefly during early fetal development. It is primarily involved in the male.
- The metanephros forms the permanent kidneys and appears in the fifth week of development.
Kidney Systems
- The metanephros contains excretory units
- These units develop from metanephric mesoderm.
- The ureteric bud forms the collecting system.
Kidney Development
- At the beginning of the fourth week, the pronephros forms groups of cells (7-10) in the cervical region.
- Vestigial excretory units (nephrotomes) form.
- Internal and external glomeruli and nephric tubules develop and open into the intraembryonic cavity.
- By the end of the fourth week, the pronephric system is gone.
The Mesonephros
- Forms in the thoracic and lumbar regions.
- Characterized by excretory units and its own collecting duct (mesonephric or Wolffian duct)
- In males, some caudal tubules from the mesonephric duct participate in the formation of the genital system .
- In females, the mesonephric duct disappears.
The Metanephros (The Definitive Kidney):
- Forms the definitive kidney.
- Appears in the fifth week.
- Excretory units develop from metanephric mesoderm.
Collecting System
- Develops from the ureteric bud.
- The bud penetrates the metanephric tissue,
- The bud dilates and forms the primitive renal pelvis.
- Splits into cranial and caudal portions (future major calyces).
- The first two new buds are produced by the calyx while penetrating the metanephric tissue
- Tubules subsequently form until the fifth month.
- Tubules enlarge, absorb other tubules, forming the minor calyces of the renal pelvis.
Collecting Tubules
- Fifth and successive generations of collecting tubules elongate and converge on the minor calyx.
- These tubules form the renal pyramid.
- These tubules are part of the ureter, renal pelvis, major and minor calyces, and around 1 to 3 million collecting tubules.
Excretory System (Nephrons)
- Collecting tubule has a metanephric tissue cap.
- The cells in the cap form small vesicles (renal vesicles).
- The renal vesicles develop into small S-shaped tubules
- Capillaries grow into a pocket at one end of the tubules; these become glomeruli.
- The tubules plus their glomeruli form nephrons.
- The proximal end of each nephron forms Bowman's capsule, indented by the glomerulus.
Kidney Formation Process
- The distal end of the tubules connects to a collecting tubule
- Formation of proximal convoluted tubule, Henle's loop, and distal convoluted tubule.
- The kidney develops from metanephric mesoderm and the ureteric bud.
Nephrons Formation and Function
- Nephrons are formed until birth (around 1 million in each kidney).
- Urine production begins early in gestation.
- Glomerular capillaries differentiate by the 10th week.
- At birth, the kidneys have a lobulate appearance, that disappears during infancy.
Renal Dysplasias and Agenesis
- A spectrum of severe malformations.
- Can require dialysis and transplantation early in life.
- Examples include multicystic dysplastic kidney.
Multicystic Dysplastic Kidney
- An example of renal anomalies where multiple cysts develop and surround undifferentiated cells.
- Nephrons fail to develop
- The ureteric bud fails to branch
- Collecting ducts never form.
- Can lead to kidney involution and agenesis.
Renal Agenesis
- Can be unilateral (1 per 1000 births) or bilateral (1 in 10,000 births).
- May be asymptomatic if unilateral, but bilateral results in renal failure.
- Characteristic of Potter Sequence: anuria, oligohydramnios, hypoplastic lungs.
- Other defects like abnormal vagina/uterus, vas deferens, or seminal vesicles may occur with renal agenesis in 85% of cases.
Congenital Polycystic Kidney Disease
- Cysts develop from collecting ducts.
- Autosomal recessive (1/5000 births) results in renal failure early in life.
- Autosomal dominant (1/500-1/1000 births) is less severe and failure may occur in adulthood
Ureter Duplication
- Occurs from early splitting of the ureteric bud.
- Ureter may be partial or complete.
- Can result in one ureter opening into the bladder, and the other ectopic (opening into the vagina, urethra, or vestibule).
Kidney Position
- Kidneys initially in pelvic region, migrate cranially, laterally, and rotate.
- Position influenced by body curvature development in lumbar/sacral regions.
- Renal vessels develop at different levels, with lower vessels often degenerating.
Abnormal Kidney Location (Clinical Correlates)
- Pelvic kidneys: one or both kidneys don't ascend properly, rest near iliac artery
- Horseshoe kidney (1/600): fusion of kidneys, often blocked by inferior mesenteric artery
Kidney Function
- Functional metanephros forms near 12th week.
- Urine flows into amniotic cavity and recycles through the fetus.
- Kidneys aren't responsible for excretion of waste during fetal life; placenta does it.
Bladder and Urethra
- Cloaca divides into urogenital sinus (anterior) and anal canal (posterior) during weeks 4-7
- Urorectal septum a layer of mesoderm dividing the anus and urogenital structures.
- Urogenital sinus forms the urinary bladder and urethra.
- 3 parts to urogenital sinus (1) urinary bladder, (2) pelvic part of urethra, (3) phallic part of urethra.
Ureters
- Caudal portions of mesonephric ducts absorbed into the bladder.
- Ureters emerge separately from the bladder.
- Ureteric openings move cranially as kidneys ascend.
- The mesodermal lining of the trigone changes to endodermal epithelium of the bladder.
Urethra
- Urethra epithelium of both sexes originates in endoderm.
- Surrounding connective tissue and smooth muscle come from visceral mesoderm.
- Male prostatic urethra proliferates to create prostate gland.
- Female urethra has urogenital and paraurethral glands.
Clinical Correlates: Bladder Defects:
- Urachal fistula: allantois remains open, urine drains from umbilicus.
- Urachal cyst: allantois partially persists, forming a cyst.
- Urachal sinus: upper part of allantois persists, forming a sinus connecting to bladder.
Exstrophy of the Bladder
- Ventral body wall defect.
- Bladder mucosa exposed.
- Related to failure of lateral body wall folds to fuse in the midline.
- Rare anomaly (2/100,000 births).
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Description
Explore the intricate processes involved in the development of the urinary system, focusing on structures such as the pronephros, mesonephros, and metanephros. This quiz covers the stages of kidney development and the formation of excretory units. Understand how these systems evolve during fetal growth.