Development of the Urinary System
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Questions and Answers

What is the name of the first set of excretory organs that develops during embryogenesis?

  • Mesonephros
  • Ureteric bud
  • Pronephros (correct)
  • Metanephros
  • Which of the following structures forms the collecting system of the kidneys?

  • Mesonephric duct
  • Ureteric bud (correct)
  • Pronephric duct
  • Metanephric mesoderm
  • What is the name of the excretory units that form in the mesonephros?

  • Metanephric tubules
  • Nephrotomes
  • Nephrons (correct)
  • Glomeruli
  • At what stage of development does the metanephros, the permanent kidney, appear?

    <p>Fifth week (C)</p> Signup and view all the answers

    Which of the following is NOT a common congenital disorder of the urinary tract?

    <p>Spina bifida (A)</p> Signup and view all the answers

    The mesonephric duct persists in males to form which of the following structures?

    <p>Vas deferens (B)</p> Signup and view all the answers

    What is the name of the structure that forms the primitive renal pelvis?

    <p>Ureteric bud (B)</p> Signup and view all the answers

    Which of the following statements about the pronephros is TRUE?

    <p>It is represented by 7 to 10 solid cell groups in the cervical region. (D)</p> Signup and view all the answers

    What is the typical incidence of bilateral renal agenesis?

    <p>1/10,000 births (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Potter sequence?

    <p>Polycystic kidneys (B)</p> Signup and view all the answers

    Which type of polycystic kidney disease is more common?

    <p>Autosomal dominant (A)</p> Signup and view all the answers

    In which type of polycystic kidney disease do cysts form from all segments of the nephron?

    <p>Autosomal dominant (B)</p> Signup and view all the answers

    What is the typical age of onset of renal failure in autosomal recessive polycystic kidney disease?

    <p>Infancy or childhood (B)</p> Signup and view all the answers

    Which of the following contributes to the ascent of the kidney during development?

    <p>Diminution of body curvature (A)</p> Signup and view all the answers

    What is the typical position of the renal pelvis after the kidney's 90° rotation?

    <p>Facing the midline (C)</p> Signup and view all the answers

    Which of the following is a possible location for an ectopic ureter?

    <p>Vagina (D)</p> Signup and view all the answers

    Regarding the development of the urethra, which statement is TRUE?

    <p>The epithelium of the urethra originates entirely from the endoderm. (B)</p> Signup and view all the answers

    What is the primary reason for the development of the ejaculatory ducts in males?

    <p>Migration of the mesonephric ducts to the prostatic urethra. (C)</p> Signup and view all the answers

    Which of the following developmental abnormalities results in a cystic dilation of a portion of the allantois?

    <p>Urachal cyst (B)</p> Signup and view all the answers

    What is the primary cause of exstrophy of the bladder?

    <p>Incomplete closure of the lateral body wall folds in the pelvic region. (B)</p> Signup and view all the answers

    Which of the following is NOT a consequence of the ascent of the kidneys during development?

    <p>The lining of the bladder is replaced with endodermal epithelium. (C)</p> Signup and view all the answers

    During fetal development, what is the primary function of the placenta?

    <p>Absorption of nutrients from the mother's blood (D)</p> Signup and view all the answers

    What anatomical structure forms from the obliterated allantois?

    <p>Median umbilical ligament (D)</p> Signup and view all the answers

    What is a pelvic kidney?

    <p>A kidney that is located in the pelvis due to a failure to ascend during development (C)</p> Signup and view all the answers

    The ureters initially develop as outgrowths from which structure?

    <p>Mesonephric ducts (C)</p> Signup and view all the answers

    Which of the following structures is NOT derived from the urogenital sinus?

    <p>Anal canal (C)</p> Signup and view all the answers

    What specific structure prevents a horseshoe kidney from ascending to its normal position in the abdomen?

    <p>Root of the inferior mesenteric artery (D)</p> Signup and view all the answers

    At what gestational age does the definitive kidney become functional?

    <p>12th week (A)</p> Signup and view all the answers

    What is the primary reason for the difference in the phallic part of the urogenital sinus between males and females?

    <p>Differences in the development of the genital tubercle (A)</p> Signup and view all the answers

    What is the primary source of formation for collecting tubules?

    <p>Ureteric bud (C)</p> Signup and view all the answers

    Which of the following structures forms from the second order tubules?

    <p>Minor calyces (C)</p> Signup and view all the answers

    At what stage of development do the glomeruli form?

    <p>Simultaneously with the formation of the S-shaped tubules (C)</p> Signup and view all the answers

    What is the role of the metanephric tissue cap cells?

    <p>Giving rise to renal vesicles (D)</p> Signup and view all the answers

    Which of these is a direct consequence of the ureteric bud failing to branch?

    <p>Inability of the collecting ducts to form (B)</p> Signup and view all the answers

    What is the primary reason for the lobulation of the kidney at birth?

    <p>Incomplete development of the nephrons (B)</p> Signup and view all the answers

    Which of the following is a CORRECT statement regarding nephron formation?

    <p>Nephron formation ceases at birth. (D)</p> Signup and view all the answers

    What is the primary function of the Bowman's capsule?

    <p>Filtering waste products from blood (B)</p> Signup and view all the answers

    Flashcards

    Pronephros

    The first set of excretory organs that is rudimentary and nonfunctional.

    Mesonephros

    The second set of excretory organs that may function briefly during early fetal development.

    Metanephros

    The definitive kidney that forms the permanent kidney by the fifth week of development.

    Nephrotomes

    Vestigial excretory units formed by the pronephros that regress before maturity.

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    Ureteric bud

    An outgrowth of the mesonephric duct that leads to the development of the collecting system.

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    Renal pelvis

    The dilated section formed by the ureteric bud that connects to the ureter.

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    Congenital anomalies

    Common developmental disorders of the urinary tract like horseshoe kidney or ectopic urethra.

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    Position changes of kidneys

    The movement of kidneys during development affecting their final location.

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    Nephron

    The functional unit of the kidney responsible for urine formation.

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    Bowman's Capsule

    A cup-shaped structure surrounding the glomerulus in the nephron.

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    Collecting Tubules

    Tubes that transport urine from the nephron to the renal pelvis.

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    Glomerulus

    A network of capillaries involved in the filtration of blood in nephrons.

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    Multicystic Dysplastic Kidney

    A kidney abnormality characterized by non-functioning structures surrounded by undifferentiated cells.

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    Proximal Convoluted Tubule

    The first segment of the renal tubule that reabsorbs water and nutrients.

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    Renal Pyramid

    Structures in the kidney formed by collecting tubules converging on the minor calyx.

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    Renal Agenesis

    A condition where one or both kidneys fail to develop, can be unilateral or bilateral.

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    Potter Sequence

    Symptoms resulting from renal agenesis, including anuria, oligohydramnios, and hypoplastic lungs.

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    Congenital Polycystic Kidney Disease

    A condition where numerous cysts form in the kidneys, leading to dysfunction and potential renal failure.

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    Autosomal Recessive PKD

    A genetic disorder with cysts forming from collecting ducts; causes renal failure in infancy.

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    Autosomal Dominant PKD

    A genetic disorder where cysts form from all nephron segments, typically resulting in renal failure in adulthood.

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    Ureter Duplication

    Condition resulting from the early splitting of the ureteric bud, leading to two ureters.

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    Kidney Migration

    The process where kidneys ascend from pelvic position to abdominal position during development.

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    Arterial Supply During Kidney Ascension

    The kidneys receive blood supply from pelvic aorta branches that shift higher as they ascend.

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    Urethra Development

    The epithelium of the urethra originates from endoderm in both sexes, while surrounding tissue comes from mesoderm.

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    Prostatic Urethra in Males

    The epithelium of the prostatic urethra proliferates during the 3rd month and leads to the formation of the prostate gland.

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    Urachal Fistula

    A condition occurring when the intraembryonic allantois lumen persists, allowing urine to drain from the umbilicus.

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    Exstrophy of the Bladder

    A rare defect where bladder mucosa is exposed due to failed closure of lateral body wall folds.

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    Urachal Cyst

    Occurs when a localized area of the allantois persists, leading to a cystic dilation due to secretory activity.

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    Pelvic Kidney

    A kidney that fails to ascend and remains near the common iliac artery.

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    Horseshoe Kidney

    A condition where the lower poles of kidneys fuse during ascent, resembling a horseshoe.

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    Accessory Renal Arteries

    Extra arteries that supply blood to the kidneys, often from the aorta.

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    Function of the Kidney in Fetus

    The metanephros becomes functional around the 12th week, producing urine that mixes with amniotic fluid.

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    Cloaca Division

    The cloaca divides into the urogenital sinus and anal canal during fetal development.

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    Urogenital Sinus

    Divided into three parts: urinary bladder, pelvic part, and phallic part.

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    Urachus

    A fibrous cord that connects the bladder apex to the umbilicus after the allantois is obliterated.

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    Study Notes

    Development of the Urinary System

    • The urinary and genital systems develop from a common mesodermal ridge (intermediate mesoderm).
    • The pronephros, the first excretory organ, is rudimentary and nonfunctional.
    • The mesonephros, the second excretory organ, may function briefly during early fetal development. It is primarily involved in the male.
    • The metanephros forms the permanent kidneys and appears in the fifth week of development.

    Kidney Systems

    • The metanephros contains excretory units
    • These units develop from metanephric mesoderm.
    • The ureteric bud forms the collecting system.

    Kidney Development

    • At the beginning of the fourth week, the pronephros forms groups of cells (7-10) in the cervical region.
    • Vestigial excretory units (nephrotomes) form.
    • Internal and external glomeruli and nephric tubules develop and open into the intraembryonic cavity.
    • By the end of the fourth week, the pronephric system is gone.

    The Mesonephros

    • Forms in the thoracic and lumbar regions.
    • Characterized by excretory units and its own collecting duct (mesonephric or Wolffian duct)
    • In males, some caudal tubules from the mesonephric duct participate in the formation of the genital system .
    • In females, the mesonephric duct disappears.

    The Metanephros (The Definitive Kidney):

    • Forms the definitive kidney.
    • Appears in the fifth week.
    • Excretory units develop from metanephric mesoderm.

    Collecting System

    • Develops from the ureteric bud.
    • The bud penetrates the metanephric tissue,
    • The bud dilates and forms the primitive renal pelvis.
    • Splits into cranial and caudal portions (future major calyces).
    • The first two new buds are produced by the calyx while penetrating the metanephric tissue
    • Tubules subsequently form until the fifth month.
    • Tubules enlarge, absorb other tubules, forming the minor calyces of the renal pelvis.

    Collecting Tubules

    • Fifth and successive generations of collecting tubules elongate and converge on the minor calyx.
    • These tubules form the renal pyramid.
    • These tubules are part of the ureter, renal pelvis, major and minor calyces, and around 1 to 3 million collecting tubules.

    Excretory System (Nephrons)

    • Collecting tubule has a metanephric tissue cap.
    • The cells in the cap form small vesicles (renal vesicles).
    • The renal vesicles develop into small S-shaped tubules
    • Capillaries grow into a pocket at one end of the tubules; these become glomeruli.
    • The tubules plus their glomeruli form nephrons.
    • The proximal end of each nephron forms Bowman's capsule, indented by the glomerulus.

    Kidney Formation Process

    • The distal end of the tubules connects to a collecting tubule
    • Formation of proximal convoluted tubule, Henle's loop, and distal convoluted tubule.
    • The kidney develops from metanephric mesoderm and the ureteric bud.

    Nephrons Formation and Function

    • Nephrons are formed until birth (around 1 million in each kidney).
    • Urine production begins early in gestation.
    • Glomerular capillaries differentiate by the 10th week.
    • At birth, the kidneys have a lobulate appearance, that disappears during infancy.

    Renal Dysplasias and Agenesis

    • A spectrum of severe malformations.
    • Can require dialysis and transplantation early in life.
    • Examples include multicystic dysplastic kidney.

    Multicystic Dysplastic Kidney

    • An example of renal anomalies where multiple cysts develop and surround undifferentiated cells.
    • Nephrons fail to develop
    • The ureteric bud fails to branch
    • Collecting ducts never form.
    • Can lead to kidney involution and agenesis.

    Renal Agenesis

    • Can be unilateral (1 per 1000 births) or bilateral (1 in 10,000 births).
    • May be asymptomatic if unilateral, but bilateral results in renal failure.
    • Characteristic of Potter Sequence: anuria, oligohydramnios, hypoplastic lungs.
    • Other defects like abnormal vagina/uterus, vas deferens, or seminal vesicles may occur with renal agenesis in 85% of cases.

    Congenital Polycystic Kidney Disease

    • Cysts develop from collecting ducts.
    • Autosomal recessive (1/5000 births) results in renal failure early in life.
    • Autosomal dominant (1/500-1/1000 births) is less severe and failure may occur in adulthood

    Ureter Duplication

    • Occurs from early splitting of the ureteric bud.
    • Ureter may be partial or complete.
    • Can result in one ureter opening into the bladder, and the other ectopic (opening into the vagina, urethra, or vestibule).

    Kidney Position

    • Kidneys initially in pelvic region, migrate cranially, laterally, and rotate.
    • Position influenced by body curvature development in lumbar/sacral regions.
    • Renal vessels develop at different levels, with lower vessels often degenerating.

    Abnormal Kidney Location (Clinical Correlates)

    • Pelvic kidneys: one or both kidneys don't ascend properly, rest near iliac artery
    • Horseshoe kidney (1/600): fusion of kidneys, often blocked by inferior mesenteric artery

    Kidney Function

    • Functional metanephros forms near 12th week.
    • Urine flows into amniotic cavity and recycles through the fetus.
    • Kidneys aren't responsible for excretion of waste during fetal life; placenta does it.

    Bladder and Urethra

    • Cloaca divides into urogenital sinus (anterior) and anal canal (posterior) during weeks 4-7
    • Urorectal septum a layer of mesoderm dividing the anus and urogenital structures.
    • Urogenital sinus forms the urinary bladder and urethra.
    • 3 parts to urogenital sinus (1) urinary bladder, (2) pelvic part of urethra, (3) phallic part of urethra.

    Ureters

    • Caudal portions of mesonephric ducts absorbed into the bladder.
    • Ureters emerge separately from the bladder.
    • Ureteric openings move cranially as kidneys ascend.
    • The mesodermal lining of the trigone changes to endodermal epithelium of the bladder.

    Urethra

    • Urethra epithelium of both sexes originates in endoderm.
    • Surrounding connective tissue and smooth muscle come from visceral mesoderm.
    • Male prostatic urethra proliferates to create prostate gland.
    • Female urethra has urogenital and paraurethral glands.

    Clinical Correlates: Bladder Defects:

    • Urachal fistula: allantois remains open, urine drains from umbilicus.
    • Urachal cyst: allantois partially persists, forming a cyst.
    • Urachal sinus: upper part of allantois persists, forming a sinus connecting to bladder.

    Exstrophy of the Bladder

    • Ventral body wall defect.
    • Bladder mucosa exposed.
    • Related to failure of lateral body wall folds to fuse in the midline.
    • Rare anomaly (2/100,000 births).

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    Description

    Explore the intricate processes involved in the development of the urinary system, focusing on structures such as the pronephros, mesonephros, and metanephros. This quiz covers the stages of kidney development and the formation of excretory units. Understand how these systems evolve during fetal growth.

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