Development of Intermediate Mesoderm

¿Qué es el mesodermo intermedio?

¿Qué sistema del cuerpo se desarrolla a partir del mesodermo intermedio?

¿Cuál es una de las estructuras que se desarrolla del mesodermo intermedio?

¿Qué tipo de movimientos morfogenéticos experimenta el mesodermo intermedio?

¿Cuáles son dos de los factores de transcripción involucrados en el desarrollo del mesodermo intermedio?

¿Qué vía de señalización juega un papel crucial en la formación del mesodermo intermedio?

Formation and Fate of Intermediate Mesoderm

Intermediate mesoderm (IM) is a transient embryonic tissue that arises from the lateral plate mesoderm during gastrulation in mammals.
IM forms from the posterior region of the embryo, adjacent to the primitive streak.

Developmental Fate

IM gives rise to the excretory system, including:
- Kidneys (metanephros)
- Ureters
- Bladder
- Urethra
IM also contributes to the development of:
- Adrenal glands
- Gonadal ridge (precursor to ovaries and testes)

Morphogenetic Movements

IM undergoes complex morphogenetic movements, involving:
- Lateral expansion and folding
- Rotation and migration towards the midline
- Segregation into distinct domains (e.g., nephrogenic cord, Wolffian duct)

Gene Expression and Regulation

IM development is regulated by a network of transcription factors, including:
- Pax2 and Pax8 (kidney development)
- Lim1 and Lhx1 (nephrogenesis)
- Gata4 and Gata6 (adrenal development)
Signaling pathways, such as Wnt and FGF, also play crucial roles in IM patterning and differentiation.

Learn about the formation and fate of intermediate mesoderm, including its development, morphogenetic movements, and gene expression regulation in the embryonic development of mammals.