206 Questions
During which period does the development of the heart from the embryonic period to the fetal period occur?
Weeks 9 to 38 of the fetal period
Where do cardiac progenitor cells form in the embryonic period?
Epiblast layer
What structure is formed by the fusion of endocardial tubes in the embryonic period?
Primitive heart tube
When does the first heartbeat occur during the development of the heart?
At day 22
What are the three layers of the heart during the fetal period?
Endocardium, myocardium, and epicardium
What does the basal part of the bulbus cordis become during development?
Trabeculated part of the right ventricle
Which vein develops into the inferior vena cava?
Right vitelline vein
What is the most common type of Ventricular Septal Defect (VSD)?
Membranous Septal Defect
What causes Patent Ductus Arteriosus (PDA)?
Failure of the muscular wall to contract
Which congenital malformation results from a failure of adhesion between the flap and septum?
Atrial Septal Defect (ASD)
What is characteristic of Tetralogy of Fallot?
Right ventricular hypertrophy
What do fetal circulation changes at birth include?
Closure of the ductus venosus
During the separation of the pulmonary and systemic circulations, what communication is maintained to permit blood flow and bypass non-functioning lungs?
Foramen ovale
Which structure forms the smooth wall of the left atrium while retaining a trabeculated appearance as the left auricle?
Pulmonary vein
What contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Fusion of the septum primum and endocardial cushions
Which cells contribute to the formation of the aorticopulmonary septum during the development of outflow tracts?
Neural crest cells
What do vitelline arteries form during development?
Arteries in the dorsal mesentery
Which veins drain the head, neck, and body wall of the embryo into the heart at 4 weeks?
Common cardinal veins
Which structure develops from a single to a double tube during heart development?
Truncus arteriosus
What is responsible for malformations such as patent ductus arteriosus, atrial septal defects, and ventricular septal defects?
Developmental aberrations
During fetal life, in which of the following structures is the percent hemoglobin/oxygen saturation level of fetal blood the lowest?
Right atrium
What tissue do the vitelline arteries supply?
Endoderm
Which nerve is associated with the aortic arches IV and VI?
X – Vagus Nerve
What defect is necessary to survive with pulmonary atresia?
Atrial septal defect
Which of the following structure gives rise to the coronary sinus?
Left horn of sinus venosus
During what weeks of development do the pharyngeal/branchial arches form?
4th to 5th
What is the primary cause of Patent Ductus Arteriosus (PDA)?
Failure of the muscular wall to contract
Which congenital malformation can result in cyanosis?
Atrial Septal Defects (ASD)
What is the most common type of Ventricular Septal Defect (VSD)?
Membranous Septal Defect
What characterizes Tetralogy of Fallot?
Pulmonary stenosis and right ventricular hypertrophy
What does the inferior vena cava develop from?
Right vitelline vein, right subcardinal vein, supracardinal veins, and sacrocardinal vein
What is the postnatal circulation change at birth related to the ductus arteriosus?
Closure of the ductus arteriosus
During which period does the heart shift position and the endocardial tubes fuse to form the primitive heart tube?
Embryonic period (weeks 1 to 8)
What structure holds the primitive heart tube in position during its movement into the pericardial cavity?
Dorsal mesocardium
At what stage does the heart form four subdivisions: sinus venosus, primitive atrium, primitive ventricle, and bulbus cordis?
At 22 days
What do angiogenic cells develop into during the embryonic period of heart development?
Blood islands and myoblasts
Which part of the bulbus cordis becomes the conus cordis during heart development?
Middle part
In which layer of the heart do cardiac progenitor cells begin to form during the embryonic period?
Splanchnic mesoderm
During heart development, what structure gives rise to the coronary sinus?
Bulbis cordis
What is responsible for malformations such as patent ductus arteriosus, atrial septal defects, and ventricular septal defects?
Bulbis cordis
During fetal life, in which of the following structures is the percent hemoglobin/oxygen saturation level of fetal blood the lowest?
Truncus arteriosus
What contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Endocardial tubes
Which cells contribute to the formation of the aorticopulmonary septum during the development of outflow tracts?
Cardiac progenitor cells
Where do cardiac progenitor cells form in the embryonic period?
Pericardium
During the separation of the pulmonary and systemic circulations, what communication between the left and right sides is maintained to permit blood flow and bypass non-functioning lungs?
Foramen ovale
Which structure forms the smooth wall of the left atrium while retaining a trabeculated appearance as the left auricle?
Pulmonary vein
What contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Endocardial cushions
Which structure gives rise to the coronary sinus?
Sinus venosus derivatives
What causes Patent Ductus Arteriosus (PDA)?
Failure of closure of ductus arteriosus after birth
What structure is formed by the fusion of endocardial cushions in fetal heart development?
Atrioventricular canal
During fetal life, in which of the following structures is the percentage hemoglobin/oxygen saturation level of fetal blood the lowest?
Right Atrium
Which nerve is associated with the aortic arches IV and VI?
VI – Abducent Nerve
What cardinal vein is responsible for draining the body wall?
Supracardinal
What defect is necessary to survive with pulmonary atresia?
Atrial septal defect
At birth, a child’s skin appears much less pink than would be expected. The physician determines that the child’s ductus arteriosus did not close. The child has a blue tint because the ductus arteriosus is shunting blood from the ____.
Pulmonary Artery; Aorta
During what weeks of development do the pharyngeal/branchial arches form?
3rd to 4th
What structure holds the primitive heart tube in position during its movement into the pericardial cavity?
Dorsal mesocardium
During which period does the heart shift position and the endocardial tubes fuse to form the primitive heart tube?
Embryonic period
What does the basal part of the bulbus cordis become during development?
Trabeculated part of the right ventricle
What is responsible for malformations such as patent ductus arteriosus, atrial septal defects, and ventricular septal defects?
Cardiac progenitor cells
At what stage does the heart form four subdivisions: sinus venosus, primitive atrium, primitive ventricle, and bulbus cordis?
Day 28
What nerve is associated with the aortic arches IV and VI?
Vagus nerve
During heart development, which structure gives rise to the conus cordis?
Bulbus cordis
Which of the following is NOT associated with an Atrial Septal Defect?
Probe patency
What defect is necessary to survive with pulmonary atresia?
Atrial septal defect
Which of the following is NOT associated with Tetralogy of Fallot?
Pulmonary atresia
All arteries, veins, and lymphatic channels form from ____.
Mesoderm
During what weeks of development do the pharyngeal/branchial arches form?
3rd to 4th
What is the primary focus of the lecture objectives related to the development of the heart and cardiovascular system?
Changes in the bulbus cordis and truncus arteriosus
During heart development, which structure gives rise to the primary and secondary atrial septa and the ventricular septum?
Endocardial tubes
What is responsible for malformations such as patent ductus arteriosus, atrial septal defects, and ventricular septal defects?
Changes in the bulbus cordis
Which book provides information on cardiovascular system development from the fetus to the adult?
The Developing Human, 10th Edition
What contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Primary and secondary atrial septa
During fetal life, in which of the following structures is the percent hemoglobin/oxygen saturation level of fetal blood the lowest?
Bulbus cordis
During heart development, what structure separates the smooth part and the muscular part of the right atrium?
Crista terminalis
What contributes to the initial communication between the left and right sides of the heart during the separation of the pulmonary and systemic circulations?
Septum ovale
Which cells contribute to the formation of the aorticopulmonary septum during the development of outflow tracts?
Neural crest cells
What do the vitelline arteries form during development?
Arteries in the dorsal mesentery
What forms major arteries among the six pairs of aortic arch arteries?
Pairs 1, 2, and 3
Which vein brings oxygenated blood from the placenta and connects to the inferior vena cava via the ductus venosus?
Umbilical vein
Which condition is characterized by pulmonary stenosis, a ventricular septal defect, dextroposition of the aorta, and right ventricular hypertrophy?
Tetralogy of Fallot
What is the most common congenital heart defect, affecting 25% of people?
Ventricular Septal Defect (VSD)
What is the condition where the ductus arteriosus fails to close, causing a shunt of aortic blood into the pulmonary circulation?
Patent Ductus Arteriosus (PDA)
Which congenital malformation results from a failure of adhesion between the flap and septum secondary?
Atrial Septal Defect (ASD)
What is the condition where the endocardial cushions fail to develop properly, leading to a hole in the interatrial septum?
Endocardial Cushion Defect
Which condition results from a failure of the membranous septum to develop, leading to increased pulmonary blood flow, pulmonary hypertension, dyspnea, and heart failure?
Ventricular Septal Defect (VSD)
During heart development, what structure gives rise to the smooth wall of the left atrium while retaining a trabeculated appearance as the left auricle?
Pulmonary vein
What contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Endocardial cushions
What structure holds the primitive heart tube in position during its movement into the pericardial cavity?
Dorsal mesentery
Which cells contribute to the formation of the aorticopulmonary septum during the development of outflow tracts?
Neural crest cells
During fetal life, in which of the following structures is the percent hemoglobin/oxygen saturation level of fetal blood the lowest?
Ductus venosus
What nerve is associated with the aortic arches IV and VI?
Vagus nerve (CN X)
During heart development, which structure gives rise to the coronary sinus?
Bulbus cordis
What structure holds the primitive heart tube in position during its movement into the pericardial cavity?
Mesocardium
At what stage does the heart form four subdivisions: sinus venosus, primitive atrium, primitive ventricle, and bulbus cordis?
Week 4 of development
Which vein develops into the inferior vena cava?
Common cardinal vein
During heart development, what structure gives rise to the primary and secondary atrial septa and the ventricular septum?
Aorticopulmonary septum
What do angiogenic cells develop into during the embryonic period of heart development?
Endocardium
What causes Patent Ductus Arteriosus (PDA)?
Failure of the muscular wall to contract
Which congenital malformation results from a failure of adhesion between the flap and septum secondary?
Atrial Septal Defect (ASD)
What contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Aorticopulmonary septum formation
What characterizes Tetralogy of Fallot?
Pulmonary stenosis, a ventricular septal defect, and dextroposition of the aorta
During fetal life, in which of the following structures is the percent hemoglobin/oxygen saturation level of fetal blood the lowest?
Umbilical artery
What forms major arteries among the six pairs of aortic arch arteries?
Subcardinal veins
During which period does the primitive heart tube move into the pericardial cavity and is held in position by the dorsal mesocardium?
Embryonic period (weeks 1 to 8)
At what stage does the heart form four subdivisions: sinus venosus, primitive atrium, primitive ventricle, and bulbus cordis?
Embryonic period (weeks 1 to 8)
Which layer of the heart do cardiac progenitor cells begin to form during the embryonic period?
Epicardium
What contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Sinus venosus
What structure holds the primitive heart tube in position during its movement into the pericardial cavity?
Dorsal mesocardium
What is responsible for malformations such as patent ductus arteriosus, atrial septal defects, and ventricular septal defects?
Cardiac progenitor cells
During heart development, which structure gives rise to the primary and secondary atrial septa and the ventricular septum?
Endocardial cushions
Which cells contribute to the formation of the aorticopulmonary septum during the development of outflow tracts?
Neural crest cells
What contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Persistence of foramen ovale
What causes Patent Ductus Arteriosus (PDA)?
Inadequate development of the aorticopulmonary septum
During fetal life, in which of the following structures is the percentage hemoglobin/oxygen saturation level of fetal blood the lowest?
Ductus venosus
What forms major arteries among the six pairs of aortic arch arteries?
Pharyngeal/branchial arches
During heart development, what structure gives rise to the primitive atrium, primitive ventricle, and bulbus cordis?
Bulboatrial septum
What contributes to the formation of the aortic arches on the right and left sides during fetal development?
Pharyngeal arches
Which congenital malformation results from a failure of adhesion between the flap and septum secondary?
Tetralogy of Fallot
What is responsible for malformations such as patent ductus arteriosus, atrial septal defects, and ventricular septal defects?
Incomplete fusion of endocardial tubes
During heart development, what structure separates the smooth part and the muscular part of the right atrium?
Crista terminalis
What nerve is associated with the aortic arches IV and VI during fetal development?
Vagus nerve
During which period does the heart shift position and the endocardial tubes fuse to form the primitive heart tube?
Embryonic period (weeks 1 to 8)
What is characteristic of Tetralogy of Fallot?
Overriding aorta
What contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Endocardial cushions
What is the condition where the endocardial cushions fail to develop properly, leading to a hole in the interatrial septum?
Atrial septal defect (ASD)
At what stage does the heart form four subdivisions: sinus venosus, primitive atrium, primitive ventricle, and bulbus cordis?
Week 4
Where do cardiac progenitor cells form in the embryonic period?
Epiblast layer
During heart development, what contributes to the formation of the septum ovale, allowing blood flow from the right atrium to the left atrium?
Fusion of the septum primum and endocardial cushions
Which structure holds the primitive heart tube in position during its movement into the pericardial cavity?
Dorsal mesocardium
What contributes to the initial communication between the left and right sides of the heart during the separation of the pulmonary and systemic circulations?
Pulmonary vein sprouts from the primitive atrium
Which cells contribute to the formation of the aorticopulmonary septum during the development of outflow tracts?
Neural crest cells
What artery does pair 1 of the aortic arch arteries form during heart development?
Maxillary artery
Which vein develops into part of the inferior vena cava and portal vein?
Vitelline vein
Which vessel(s) drain blood from the head and neck region, with the cranial portion going to cerebral veins, intracranial dural sinuses, and internal jugular veins, and the cervical portions going to the superior vena cava via the right anterior cardinal vein and right common cardinal vein?
Superior vena cava
What is the primary cause of Patent Ductus Arteriosus (PDA)?
Failure of the muscular wall to contract
What is the most common type of Ventricular Septal Defect (VSD), resulting from the failure of the membranous septum to develop, leading to increased pulmonary blood flow, pulmonary hypertension, dyspnea, and heart failure?
Membranous Septal Defect
Which condition is characterized by pulmonary stenosis, a ventricular septal defect, dextroposition of the aorta, and right ventricular hypertrophy?
Tetralogy of Fallot
What structure forms major arteries among the six pairs of aortic arch arteries?
Pharyngeal/branchial arches
What causes Endocardial Cushion Defect with primum type Atrial Septal Defect (ASD) to occur?
Failure of adhesion between the flap and septum secondary
During fetal life, which structure gives rise to the coronary sinus?
Left horn of sinus venosus
What defect is NOT associated with an Atrial Septal Defect?
Probe patency
At birth, a child’s skin appears much less pink than expected. The physician determines that the child’s ductus arteriosus did not close. The child has a blue tint because the ductus arteriosus is shunting blood from the ____ to the ____.
Pulmonary Artery; Aorta
During fetal life, in which of the following structures is the percent hemoglobin/oxygen saturation level of fetal blood the lowest?
Right Atrium
During what weeks of development do the pharyngeal/branchial arches form?
4th to 5th
During week six (lymphatic vessel development), the dilated lymph sac that forms at the lower end of the thoracic duct is called the ____.
Iliac Lymph Sac
During heart development, the bulbus cordis and truncus arteriosus transform from a single tube to a double tube.
True
The aortic arches form on the right and left sides from the fetus to the adult.
True
All arteries, veins, and lymphatic channels form from the mesoderm.
True
The main cause of Tetralogy of Fallot is a defect in the development of the aortic arches.
False
The main features of heart development include the development of the pericardium and the formation of the atrial septa.
True
During heart development, the aortic arches transform from a single tube to a double tube.
False
During the embryonic period, the neural plate forms by day 22.
False
The primitive heart tube forms the adult-like pattern by day 22.
False
The first heartbeat occurs at 18 days and originates in the myocardium.
False
The basal part of the bulbus cordis becomes the trabeculated part of the right ventricle.
True
The heart consists of two layers: endocardium and myocardium.
False
The first heartbeat originates in the myocardium and forms peristalsis-like waves.
True
True or false: The AV node is responsible for conducting the electrical impulse from the SA node to the His bundle to the Purkinje fibers.
False
True or false: Persistent ostium secundum is NOT associated with an Atrial Septal Defect.
True
True or false: Atrial septal defect is necessary to survive with pulmonary atresia.
False
True or false: Pulmonary atresia is NOT associated with Tetralogy of Fallot.
False
True or false: All arteries, veins, and lymphatic channels form from the mesoderm.
True
True or false: Aortic arches IV and VI are associated with the Vagus Nerve.
True
True or false: During the separation of the pulmonary and systemic circulations, a communication between the left and right sides is maintained to permit blood flow and bypass non-functioning lungs.
True
True or false: The formation of the septum ovale allows blood flow from the right atrium to the left atrium.
True
True or false: The dorsal aortae form the descending aorta.
True
True or false: The vitelline arteries form arteries in the dorsal mesentery.
True
True or false: The formation of outflow tracts is partitioned by endocardial cushions into pulmonary and aortic trunks.
True
True or false: The smooth part and muscular part of the right atrium are separated by the crista terminalis.
True
True or false: The common cardinal veins consist of the posterior cardinal veins which drain the upper body, receive the subcardinal veins that drain the kidneys and suprarenal glands, and supracardinal veins that form the azygos and hemiazygos veins in the thoracic region and the pelvic segment of the inferior vena cava in the pelvic region
False
True or false: The inferior vena cava develops from the left vitelline vein, left subcardinal vein, supracardinal veins, and sacrocardinal vein
False
True or false: Postnatal circulation changes include the closure of the ductus venosus, the umbilical vein, and the reduction of the umbilical arteries
True
True or false: Patent Ductus Arteriosus (PDA) is a condition where the ductus arteriosus fails to close, causing a shunt of aortic blood into the systemic circulation
False
True or false: Aterial Septal Defects (ASD) result from a failure of adhesion between the flap and septum primary, with patent foramen ovale being the most common type
False
True or false: Ventricular Septal Defects (VSD) are the least common congenital heart defects, affecting only 5% of people
False
During heart development, the formation of the septum ovale allows blood flow from the left atrium to the right atrium.
False
The atrioventricular canal is formed by the fusion of the septum primum and endocardial cushions.
False
The separation of the ventricles by the interventricular septum initially places the interventricular foramen at its caudal end.
False
The aortic arch arteries consist of eight pairs, with pairs 4 and 6 forming parts of the aortic arch and pulmonary arteries.
False
The dorsal aortae form the descending aorta, while the vitelline arteries form part of the inferior vena cava.
False
The formation of the septum ovale allows blood flow from the right atrium to the left atrium.
True
During the embryonic period, the neural plate forms and the spinal cord develops by day 22.
False
True or false: Atrial septal defect is NOT associated with an Atrial Septal Defect.
False
The primitive heart tube forms the sinus venosus, primitive atrium, primitive ventricle, and bulbus cordis.
True
True or false: Aortic valve stenosis is necessary to survive with pulmonary atresia.
False
The first heartbeat occurs at 22 days and originates in the endocardium.
False
True or false: Pulmonary atresia is NOT associated with Tetralogy of Fallot.
False
During the fetal period, the heart consists of two layers: endocardium and myocardium.
False
True or false: All arteries, veins, and lymphatic channels form from Mesoderm.
True
The basal part of the bulbus cordis becomes the trabeculated part of the left ventricle.
False
True or false: The aortic arches I, II, IV are important for the abdomen and thorax.
False
The first heartbeat originates in the myocardium and forms peristalsis-like waves.
True
True or false: Aortic arch IV forms the Right subclavian artery on the right side of the embryo and the Arch of aorta on the left.
True
True or false: The lecture objectives include the development of the foramen ovale, allowing blood flow from the right atrium to the left atrium.
False
True or false: The book 'Langman's Medical Embryology, 14th edition' provides information on cardiovascular system development from the fetus to the adult.
True
True or false: The coronary sinus is responsible for draining the body wall.
False
True or false: The closing of the ductus venosus and the umbilical vein are postnatal circulation changes.
True
True or false: Ventricular Septal Defects (VSD) are the most common congenital heart defects, affecting 25% of people.
False
True or false: The dorsal aortae form the ascending aorta.
False
True or false: The anterior cardinal veins drain blood from the head and neck region, and the cranial portion goes to cerebral veins, intracranial dural sinuses, and internal jugular veins. The cervical portions go to the superior vena cava via the right anterior cardinal vein and right common cardinal vein.
True
True or false: Postnatal circulation changes include the closure of the ductus venosus, the umbilical vein, and the reduction of the umbilical arteries.
True
True or false: Endocardial Cushion Defect with primum type ASD is a rare defect that can cause significant problems.
True
True or false: Ventricular Septal Defects (VSD) are the most common congenital heart defects, affecting 25% of people.
True
True or false: Aterial Septal Defects (ASD) result from a failure of adhesion between the flap and septum secondary, with patent foramen ovale being the most common type.
True
True or false: Tetralogy of Fallot is a condition characterized by pulmonary stenosis, a ventricular septal defect, dextroposition of the aorta, and left ventricular hypertrophy.
False
Study Notes
-
The heart develops from the cardiac loop, which includes the sinus venosus derivatives.
-
Left Horn: the coronary sinus and oblique vein of the left atrium.
-
Right Horn: the smooth part (sinus venarum) and muscular part (auricle) of the right atrium, separated by the crista terminalis.
-
Sinus Venosus Derivatives: 1. Right venous valve (Valve of inferior vena cava & Valve of coronary sinus), 2. Left venous valve (becomes part of the septum secundum), 3. Pulmonary vein sprouts from the primitive atrium and becomes the smooth wall of the left atrium while the portion derived from the left side of the primitive atrium retains a trabeculated appearance as the left auricle.
-
During the separation of the pulmonary and systemic circulations, a communication between the left and right sides is maintained to permit blood flow and bypass non-functioning lungs.
-
Atrioventricular septation: 1. Formation of the atrioventricular canal with endocardial cushions, 2. Fusion of the septum primum and endocardial cushions, forming the right and left canals, 3. Formation of the septum ovale (foramen ovale) allowing blood flow from right atrium to left atrium.
-
Separation of the ventricles by the interventricular septum: 1. A crescent-shaped fold composed of muscular and endocardial tissue, 2. Initially the interventricular foramen is at its cranially end, 3. The septum consists of two parts: a membranous part (endocardial tissue) and a muscular part (muscular tissue), 4. After closure, the right ventricle communicates with the pulmonary trunk and the left ventricle with the aorta.
-
Formation of outflow tracts: 1. Partitioned by endocardial cushion into pulmonary and aortic trunks, 2. Two spiral mesodermal ridges form the aorticopulmonary septum, 3. Neural crest cells contribute to septum formation, 4. Muscular tissue forms the semilunar valves, 5. Blood from the right ventricle flows into the pulmonary trunk and blood from the left ventricle flows into the aorta.
-
Vascular development: 1. Blood islands develop in the body, chorion, and connecting stalk, 2. Endothelial cells form angioblasts and vascular plexuses throughout the embryo, 3. Three separate circulations (vitelline, chorionic, and intra-embryonic) are soon interconnected.
-
Aortic arch arteries: 1. Six pairs of aortic arch arteries, 2. Pairs 1, 2, and 3 form major arteries, 3. Pairs 4 and 6 form parts of the aortic arch and pulmonary arteries.
-
Fate of paired dorsal aortae, vitelline, and umbilical arteries: 1. Dorsal aortae form the descending aorta, 2. Vitelline arteries form arteries in the dorsal mesentery, 3. Umbilical arteries form the internal iliac arteries and medial umbilical ligaments.
-
Three paired veins drain into the heart at 4 weeks: 1. Vitelline veins drain the yolk sac and form part of the inferior vena cava and portal vein, 2. Umbilical veins bring oxygenated blood from the placenta and connect to the inferior vena cava via the ductus venosus, 3. Common cardinal veins drain the head, neck, and body wall of the embryo.
-
The heart develops from the cardiac loop, which includes the sinus venosus derivatives.
-
Left Horn: the coronary sinus and oblique vein of the left atrium.
-
Right Horn: the smooth part (sinus venarum) and muscular part (auricle) of the right atrium, separated by the crista terminalis.
-
Sinus Venosus Derivatives: 1. Right venous valve (Valve of inferior vena cava & Valve of coronary sinus), 2. Left venous valve (becomes part of the septum secundum), 3. Pulmonary vein sprouts from the primitive atrium and becomes the smooth wall of the left atrium while the portion derived from the left side of the primitive atrium retains a trabeculated appearance as the left auricle.
-
During the separation of the pulmonary and systemic circulations, a communication between the left and right sides is maintained to permit blood flow and bypass non-functioning lungs.
-
Atrioventricular septation: 1. Formation of the atrioventricular canal with endocardial cushions, 2. Fusion of the septum primum and endocardial cushions, forming the right and left canals, 3. Formation of the septum ovale (foramen ovale) allowing blood flow from right atrium to left atrium.
-
Separation of the ventricles by the interventricular septum: 1. A crescent-shaped fold composed of muscular and endocardial tissue, 2. Initially the interventricular foramen is at its cranially end, 3. The septum consists of two parts: a membranous part (endocardial tissue) and a muscular part (muscular tissue), 4. After closure, the right ventricle communicates with the pulmonary trunk and the left ventricle with the aorta.
-
Formation of outflow tracts: 1. Partitioned by endocardial cushion into pulmonary and aortic trunks, 2. Two spiral mesodermal ridges form the aorticopulmonary septum, 3. Neural crest cells contribute to septum formation, 4. Muscular tissue forms the semilunar valves, 5. Blood from the right ventricle flows into the pulmonary trunk and blood from the left ventricle flows into the aorta.
-
Vascular development: 1. Blood islands develop in the body, chorion, and connecting stalk, 2. Endothelial cells form angioblasts and vascular plexuses throughout the embryo, 3. Three separate circulations (vitelline, chorionic, and intra-embryonic) are soon interconnected.
-
Aortic arch arteries: 1. Six pairs of aortic arch arteries, 2. Pairs 1, 2, and 3 form major arteries, 3. Pairs 4 and 6 form parts of the aortic arch and pulmonary arteries.
-
Fate of paired dorsal aortae, vitelline, and umbilical arteries: 1. Dorsal aortae form the descending aorta, 2. Vitelline arteries form arteries in the dorsal mesentery, 3. Umbilical arteries form the internal iliac arteries and medial umbilical ligaments.
-
Three paired veins drain into the heart at 4 weeks: 1. Vitelline veins drain the yolk sac and form part of the inferior vena cava and portal vein, 2. Umbilical veins bring oxygenated blood from the placenta and connect to the inferior vena cava via the ductus venosus, 3. Common cardinal veins drain the head, neck, and body wall of the embryo.
-
Anterior cardinal veins: drain blood from head and neck region, cranial portion goes to cerebral veins, intracranial dural sinuses, and internal jugular veins, cervical portions go to the superior vena cava via the right anterior cardinal vein and right common cardinal vein.
-
Common cardinal veins: consist of the posterior cardinal veins which drain the lower body, receive the subcardinal veins that drain the kidneys and suprarenal glands, and supracardinal veins that appear lateral to the sympathetic trunk, forming the azygos and hemiazygos veins in the thoracic region and the pelvic segment of the inferior vena cava in the pelvic region.
-
The inferior vena cava develops from the right vitelline vein, right subcardinal vein, supracardinal veins, and sacrocardinal vein.
-
Circulatory Changes at Birth: Fetal circulation includes oxygenated blood from the placenta entering the inferior vena cava and moving to the right atrium, where it is mixed with deoxygenated blood, and most of the oxygenated blood goes to the left atrium and left ventricle to be pumped to the body via the aorta. Deoxygenated blood goes to the right ventricle and pulmonary trunk, bypassing the nonfunctioning lungs via the ductus arteriosus. Postnatal circulation changes include the closure of the ductus venosus, the umbilical vein, and the reduction of the umbilical arteries.
-
Congenital Malformations: Patent Ductus Arteriosus (PDA) is a condition where the ductus arteriosus fails to close, causing a shunt of aortic blood into the pulmonary circulation. It affects females more than males, and can be associated with maternal rubella infection and premature infants. Primary cause is the failure of the muscular wall to contract. Treatment is surgical closure.
-
Congenital Malformations: Aterial Septal Defects (ASD) result from a failure of adhesion between the flap and septum secondary, with patent foramen ovale being the most common type. It affects females more than males, and most cases are clinically insignificant, but some cases can cause cyanosis.
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Congenital Malformations: Endocardial Cushion Defect with primum type ASD occurs when the endocardial cushions fail to develop properly, leading to a hole in the interatrial septum. It is a rare defect, but can cause significant problems.
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Congenital Malformations: Ventricular Septal Defects (VSD) are the most common congenital heart defects, affecting 25% of people. Membranous Septal Defect is the most common type, resulting from the failure of the membranous septum to develop, leading to increased pulmonary blood flow, pulmonary hypertension, dyspnea, and heart failure.
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Congenital Malformations: Tetralogy of Fallot is a condition characterized by pulmonary stenosis, a ventricular septal defect, dextroposition of the aorta, and right ventricular hypertrophy. It affects males more than females and is associated with cyanosis which appears later on. The pulmonary trunk is usually small.
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Dr. A Alraddadi's lecture outline covers the development of the heart from the embryonic period to the fetal period.
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During the embryonic period (weeks 1 to 8), the bilaminar germ disc forms, and gastrulation occurs. By day 18, the neural plate forms and spinal cord develops.
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Cardiac progenitor cells begin to form in the epiblast layer, lateral to the primitive streak, and migrate to the splanchnic mesoderm. They differentiate into blood islands and myoblasts.
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The cardiogenic plate forms, which is a horseshoe-shaped structure of two endocardial tubes surrounded by myoblasts.
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As the neural tube grows, the heart shifts position and the endocardial tubes fuse to form the primitive heart tube.
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Angiogenic cells develop into the dorsal aortae, which are attached to the caudal end of the primitive heart tube.
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The primitive heart tube moves into the pericardial cavity and is held in position by the dorsal mesocardium.
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The primitive heart tube forms four subdivisions: sinus venosus, primitive atrium, primitive ventricle, and bulbus cordis.
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The first heartbeat occurs at 22 days and originates in the myocardium.
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The primitive heart elongates and forms the cardiac loop by day 28. The venous and arterial ends are brought together, forming the adult-like pattern.
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During the fetal period (weeks 9 to 38), the heart continues to develop and the fetal circulation is established.
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The heart consists of three layers: endocardium, myocardium, and epicardium.
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The heart tube has four subdivisions: sinus venosus, primitive atrium, primitive ventricle, and bulbus cordis.
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The sinus venosus has paired structures that receive veins from the placenta, yolk sac, and body of the embryo.
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The primitive heart tube has a sinus venosus, a primitive atrium, a primitive ventricle, and a bulbus cordis.
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The basal part of the bulbus cordis becomes the trabeculated part of the right ventricle, the middle part forms the conus cordis, and the upper part forms the truncus arteriosus.
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The first heartbeat originates in the myocardium and forms peristalsis-like waves. By the end of week 4, coordinated contractions result in unidirectional blood flow.
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Anterior cardinal veins: drain blood from head and neck region, cranial portion goes to cerebral veins, intracranial dural sinuses, and internal jugular veins, cervical portions go to the superior vena cava via the right anterior cardinal vein and right common cardinal vein.
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Common cardinal veins: consist of the posterior cardinal veins which drain the lower body, receive the subcardinal veins that drain the kidneys and suprarenal glands, and supracardinal veins that appear lateral to the sympathetic trunk, forming the azygos and hemiazygos veins in the thoracic region and the pelvic segment of the inferior vena cava in the pelvic region.
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The inferior vena cava develops from the right vitelline vein, right subcardinal vein, supracardinal veins, and sacrocardinal vein.
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Circulatory Changes at Birth: Fetal circulation includes oxygenated blood from the placenta entering the inferior vena cava and moving to the right atrium, where it is mixed with deoxygenated blood, and most of the oxygenated blood goes to the left atrium and left ventricle to be pumped to the body via the aorta. Deoxygenated blood goes to the right ventricle and pulmonary trunk, bypassing the nonfunctioning lungs via the ductus arteriosus. Postnatal circulation changes include the closure of the ductus venosus, the umbilical vein, and the reduction of the umbilical arteries.
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Congenital Malformations: Patent Ductus Arteriosus (PDA) is a condition where the ductus arteriosus fails to close, causing a shunt of aortic blood into the pulmonary circulation. It affects females more than males, and can be associated with maternal rubella infection and premature infants. Primary cause is the failure of the muscular wall to contract. Treatment is surgical closure.
-
Congenital Malformations: Aterial Septal Defects (ASD) result from a failure of adhesion between the flap and septum secondary, with patent foramen ovale being the most common type. It affects females more than males, and most cases are clinically insignificant, but some cases can cause cyanosis.
-
Congenital Malformations: Endocardial Cushion Defect with primum type ASD occurs when the endocardial cushions fail to develop properly, leading to a hole in the interatrial septum. It is a rare defect, but can cause significant problems.
-
Congenital Malformations: Ventricular Septal Defects (VSD) are the most common congenital heart defects, affecting 25% of people. Membranous Septal Defect is the most common type, resulting from the failure of the membranous septum to develop, leading to increased pulmonary blood flow, pulmonary hypertension, dyspnea, and heart failure.
-
Congenital Malformations: Tetralogy of Fallot is a condition characterized by pulmonary stenosis, a ventricular septal defect, dextroposition of the aorta, and right ventricular hypertrophy. It affects males more than females and is associated with cyanosis which appears later on. The pulmonary trunk is usually small.
-
Anterior cardinal veins: drain blood from head and neck region, cranial portion goes to cerebral veins, intracranial dural sinuses, and internal jugular veins, cervical portions go to the superior vena cava via the right anterior cardinal vein and right common cardinal vein.
-
Common cardinal veins: consist of the posterior cardinal veins which drain the lower body, receive the subcardinal veins that drain the kidneys and suprarenal glands, and supracardinal veins that appear lateral to the sympathetic trunk, forming the azygos and hemiazygos veins in the thoracic region and the pelvic segment of the inferior vena cava in the pelvic region.
-
The inferior vena cava develops from the right vitelline vein, right subcardinal vein, supracardinal veins, and sacrocardinal vein.
-
Circulatory Changes at Birth: Fetal circulation includes oxygenated blood from the placenta entering the inferior vena cava and moving to the right atrium, where it is mixed with deoxygenated blood, and most of the oxygenated blood goes to the left atrium and left ventricle to be pumped to the body via the aorta. Deoxygenated blood goes to the right ventricle and pulmonary trunk, bypassing the nonfunctioning lungs via the ductus arteriosus. Postnatal circulation changes include the closure of the ductus venosus, the umbilical vein, and the reduction of the umbilical arteries.
-
Congenital Malformations: Patent Ductus Arteriosus (PDA) is a condition where the ductus arteriosus fails to close, causing a shunt of aortic blood into the pulmonary circulation. It affects females more than males, and can be associated with maternal rubella infection and premature infants. Primary cause is the failure of the muscular wall to contract. Treatment is surgical closure.
-
Congenital Malformations: Aterial Septal Defects (ASD) result from a failure of adhesion between the flap and septum secondary, with patent foramen ovale being the most common type. It affects females more than males, and most cases are clinically insignificant, but some cases can cause cyanosis.
-
Congenital Malformations: Endocardial Cushion Defect with primum type ASD occurs when the endocardial cushions fail to develop properly, leading to a hole in the interatrial septum. It is a rare defect, but can cause significant problems.
-
Congenital Malformations: Ventricular Septal Defects (VSD) are the most common congenital heart defects, affecting 25% of people. Membranous Septal Defect is the most common type, resulting from the failure of the membranous septum to develop, leading to increased pulmonary blood flow, pulmonary hypertension, dyspnea, and heart failure.
-
Congenital Malformations: Tetralogy of Fallot is a condition characterized by pulmonary stenosis, a ventricular septal defect, dextroposition of the aorta, and right ventricular hypertrophy. It affects males more than females and is associated with cyanosis which appears later on. The pulmonary trunk is usually small.
-
Anterior cardinal veins: drain blood from head and neck region, cranial portion goes to cerebral veins, intracranial dural sinuses, and internal jugular veins, cervical portions go to the superior vena cava via the right anterior cardinal vein and right common cardinal vein.
-
Common cardinal veins: consist of the posterior cardinal veins which drain the lower body, receive the subcardinal veins that drain the kidneys and suprarenal glands, and supracardinal veins that appear lateral to the sympathetic trunk, forming the azygos and hemiazygos veins in the thoracic region and the pelvic segment of the inferior vena cava in the pelvic region.
-
The inferior vena cava develops from the right vitelline vein, right subcardinal vein, supracardinal veins, and sacrocardinal vein.
-
Circulatory Changes at Birth: Fetal circulation includes oxygenated blood from the placenta entering the inferior vena cava and moving to the right atrium, where it is mixed with deoxygenated blood, and most of the oxygenated blood goes to the left atrium and left ventricle to be pumped to the body via the aorta. Deoxygenated blood goes to the right ventricle and pulmonary trunk, bypassing the nonfunctioning lungs via the ductus arteriosus. Postnatal circulation changes include the closure of the ductus venosus, the umbilical vein, and the reduction of the umbilical arteries.
-
Congenital Malformations: Patent Ductus Arteriosus (PDA) is a condition where the ductus arteriosus fails to close, causing a shunt of aortic blood into the pulmonary circulation. It affects females more than males, and can be associated with maternal rubella infection and premature infants. Primary cause is the failure of the muscular wall to contract. Treatment is surgical closure.
-
Congenital Malformations: Aterial Septal Defects (ASD) result from a failure of adhesion between the flap and septum secondary, with patent foramen ovale being the most common type. It affects females more than males, and most cases are clinically insignificant, but some cases can cause cyanosis.
-
Congenital Malformations: Endocardial Cushion Defect with primum type ASD occurs when the endocardial cushions fail to develop properly, leading to a hole in the interatrial septum. It is a rare defect, but can cause significant problems.
-
Congenital Malformations: Ventricular Septal Defects (VSD) are the most common congenital heart defects, affecting 25% of people. Membranous Septal Defect is the most common type, resulting from the failure of the membranous septum to develop, leading to increased pulmonary blood flow, pulmonary hypertension, dyspnea, and heart failure.
-
Congenital Malformations: Tetralogy of Fallot is a condition characterized by pulmonary stenosis, a ventricular septal defect, dextroposition of the aorta, and right ventricular hypertrophy. It affects males more than females and is associated with cyanosis which appears later on. The pulmonary trunk is usually small.
Test your knowledge on the development of cardiac structures such as the coronary sinus, oblique vein, right atrium, and cardiac loop formation. Learn about the derivatives of the sinus venosus and the sinoatrial orifice.
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