Desmogleins Cell Interaction Quiz

The proposed pathogenesis is supported by the observation that dominant epitopes in pemphigus vulgaris and foliaceus are localized to the functionally important ______ regions of desmogleins.

Pathogenic anti-Dsg3 mouse or human monoclonal antibody recognizes the N-terminal adhesive surface of ______.

The phenotype of the Dsg3 null mouse closely resembles that of human pemphigus vulgaris patients due to genetic deletion of the ______ gene.

Pemphigus autoantibodies are composed of IgG isotypes, which may be produced after ______.

The presence of autoantibodies in pemphigus is associated with specific ______ class II alleles.

Patients with pemphigus vulgaris develop painful ______ of the oral mucosa

More than half of the patients also develop flaccid blisters and widespread cutaneous ______

Pemphigus vulgaris is divided into two subgroups: the mucosal-dominant type and the mucocutaneous type with extensive skin blisters and ______

The primary skin lesions of pemphigus vulgaris are flaccid, thin-walled, easily ruptured ______

The erosions in pemphigus vulgaris have an irregular and ill-defined ______