Podcast
Questions and Answers
The proposed pathogenesis is supported by the observation that dominant epitopes in pemphigus vulgaris and foliaceus are localized to the functionally important ______ regions of desmogleins.
The proposed pathogenesis is supported by the observation that dominant epitopes in pemphigus vulgaris and foliaceus are localized to the functionally important ______ regions of desmogleins.
N-terminal
Pathogenic anti-Dsg3 mouse or human monoclonal antibody recognizes the N-terminal adhesive surface of ______.
Pathogenic anti-Dsg3 mouse or human monoclonal antibody recognizes the N-terminal adhesive surface of ______.
Dsg3
The phenotype of the Dsg3 null mouse closely resembles that of human pemphigus vulgaris patients due to genetic deletion of the ______ gene.
The phenotype of the Dsg3 null mouse closely resembles that of human pemphigus vulgaris patients due to genetic deletion of the ______ gene.
Dsg3
Pemphigus autoantibodies are composed of IgG isotypes, which may be produced after ______.
Pemphigus autoantibodies are composed of IgG isotypes, which may be produced after ______.
Signup and view all the answers
The presence of autoantibodies in pemphigus is associated with specific ______ class II alleles.
The presence of autoantibodies in pemphigus is associated with specific ______ class II alleles.
Signup and view all the answers
Patients with pemphigus vulgaris develop painful ______ of the oral mucosa
Patients with pemphigus vulgaris develop painful ______ of the oral mucosa
Signup and view all the answers
More than half of the patients also develop flaccid blisters and widespread cutaneous ______
More than half of the patients also develop flaccid blisters and widespread cutaneous ______
Signup and view all the answers
Pemphigus vulgaris is divided into two subgroups: the mucosal-dominant type and the mucocutaneous type with extensive skin blisters and ______
Pemphigus vulgaris is divided into two subgroups: the mucosal-dominant type and the mucocutaneous type with extensive skin blisters and ______
Signup and view all the answers
The primary skin lesions of pemphigus vulgaris are flaccid, thin-walled, easily ruptured ______
The primary skin lesions of pemphigus vulgaris are flaccid, thin-walled, easily ruptured ______
Signup and view all the answers
The erosions in pemphigus vulgaris have an irregular and ill-defined ______
The erosions in pemphigus vulgaris have an irregular and ill-defined ______
Signup and view all the answers
