Desipramine (Norpramin) Flashcards

Desipramine (Norpramin) Overview

• Desipramine is not considered a first-line treatment option for conditions it addresses.

Drug Classification

• Classified as an antidepressant and falls under Category G (prescription medication).

Indications

• Prescribed for depression, anxiety, and insomnia.

Side Effects

• Common side effects include:
  • Drowsiness and fatigue
  • Blurred vision and dry eyes/mouth
  • Arrhythmias and lower blood pressure
  • Changes in ECG readings
  • Gastrointestinal issues like constipation and paralytic ileus
  • Increased appetite and subsequent weight gain
  • Urinary retention and lowered libido
  • Photosensitivity and elevated blood sugar levels
  • Gynecomastia and blood dyscrasias

Nursing Responsibilities

• Monitor blood pressure and pulse regularly
• Review the patient's cardiovascular history
• Conduct ECG readings and track weight, BMI, and cholesterol levels

Drug Action

• Desipramine enhances the effects of serotonin and norepinephrine in the brain, aiding in mood regulation.

Contraindications

• Should not be used in patients with:
  • Angle-closure glaucoma
  • Heart failure (HF)
  • History of increased QT interval on ECG

Cautions

• Use with caution in patients with cardiovascular disease, prostatic enlargement, or a history of seizures.
• Increased risk of suicidality; weigh benefits against risks in pregnant patients.

Drug Interactions

• Dose adjustments might be necessary when combined with:
  • Other antidepressants, phenothiazines, carbamazepine, and class 1C antiarrhythmics.
• Enzyme inhibitors can elevate drug levels.
• Concurrent use with MAOIs may lead to lower blood pressure, increased heart rate, or fatal reactions.
• SSRIs could cause toxicity.
• Clonidine may cause a hypertensive crisis.
• Phenytoin can enhance desipramine levels.
• May reduce the absorption of levodopa when used together.
• Increased central nervous system depression when used with other depressants inclines a need for careful monitoring.

Test your knowledge on Desipramine (Norpramin) with these flashcards. This quiz covers key points such as drug classification, indications, and side effects. Perfect for medical students and professionals looking to sharpen their understanding of this antidepressant.