Dermatological Toxicities in Chemotherapy
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Questions and Answers

What is the main focus of extravasations management?

  • Administering drugs slowly
  • Applying cold compresses
  • Preventing extravasation (correct)
  • Treating local irritation and inflammation
  • Which of the following drugs can cause severe burning sensation and progress into necrosis if extravasated?

  • Etoposide
  • Oxaliplatin
  • Cisplatin
  • Paclitaxel (correct)
  • What should be verified by personnel after injecting 1-2 ml of drug to prevent extravasation?

  • Increase the drug dosage
  • Check for allergic reactions
  • Verify needle stability & blood flow return (correct)
  • Verify the drug expiration date
  • Which drug can be given as an IV infusion if extravasation occurs to reduce skin ulcers?

    <p>Dexrazoxane</p> Signup and view all the answers

    Which type of drugs cause local irritation, pain, and inflammation if extravasated?

    <p>Cisplatin</p> Signup and view all the answers

    What is the role of Dimethylsulfoxide (DMSO) in treating extravasation?

    <p>Act as a free radical scavenger to reduce skin ulcers</p> Signup and view all the answers

    What is recommended for males to address the late complication of fertility and teratogenicity after alkylating agent chemotherapy?

    <p>Sperm or gamete cryopreservation</p> Signup and view all the answers

    Which late complication can result in a patient developing tumors years after chemotherapy or radiotherapy?

    <p>Second Malignancies</p> Signup and view all the answers

    Which medication can lead to the late complication of acute myeloid leukemia among others?

    <p>Melphalan</p> Signup and view all the answers

    Which chemotherapy agent is associated with the development of Raynaud's Syndrome as a late complication?

    <p>Ifosfamide</p> Signup and view all the answers

    What late complication can occur after the use of temsirolimus?

    <p>Metabolic Syndrome</p> Signup and view all the answers

    What is the usual timeframe for hair loss to begin after one chemotherapy treatment?

    <p>7 to 10 days</p> Signup and view all the answers

    Which chemotherapeutic agent is NOT mentioned as a cause of alopecia?

    <p>Paclitaxel</p> Signup and view all the answers

    What type of hypersensitivity reactions occur with all chemotherapy agents except nitrosureas and dactinomycin?

    <p>Type 1</p> Signup and view all the answers

    Which medication should be used for prevention of hypersensitivity reactions due to the release of cremophor?

    <p>Diphenhydramine</p> Signup and view all the answers

    When should dexamethasone be administered to prevent hypersensitivity reactions with docetaxel therapy?

    <p>1 day before therapy</p> Signup and view all the answers

    What is extravasation in the context of chemotherapy?

    <p>Accidental administration of IV medications into surrounding tissues</p> Signup and view all the answers

    What is the purpose of applying warm compresses in extravasation treatment?

    <p>To increase drug distribution and absorption</p> Signup and view all the answers

    Which drug is commonly associated with Hyperpigmentation as a dermatologic toxicity?

    <p>Cytarabine</p> Signup and view all the answers

    What is the purpose of using Thiosulfate in chemotherapy?

    <p>To neutralize extravasations</p> Signup and view all the answers

    Which chemotherapy agent is associated with Palmar-Plantar Erythrodysesthesia (Hand-foot syndrome)?

    <p>5-FU</p> Signup and view all the answers

    What is the main consequence of giving chemotherapy concurrently with radiation therapy?

    <p>Increased risk of redness and inflammation</p> Signup and view all the answers

    Which side effect is associated with exposure to UV light while on 5-FU chemotherapy?

    <p>Photosensitivity reactions</p> Signup and view all the answers

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