Dermatological Toxicities in Chemotherapy
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Questions and Answers

What is the main focus of extravasations management?

  • Administering drugs slowly
  • Applying cold compresses
  • Preventing extravasation (correct)
  • Treating local irritation and inflammation

Which of the following drugs can cause severe burning sensation and progress into necrosis if extravasated?

  • Etoposide
  • Oxaliplatin
  • Cisplatin
  • Paclitaxel (correct)

What should be verified by personnel after injecting 1-2 ml of drug to prevent extravasation?

  • Increase the drug dosage
  • Check for allergic reactions
  • Verify needle stability & blood flow return (correct)
  • Verify the drug expiration date

Which drug can be given as an IV infusion if extravasation occurs to reduce skin ulcers?

<p>Dexrazoxane (C)</p> Signup and view all the answers

Which type of drugs cause local irritation, pain, and inflammation if extravasated?

<p>Cisplatin (B)</p> Signup and view all the answers

What is the role of Dimethylsulfoxide (DMSO) in treating extravasation?

<p>Act as a free radical scavenger to reduce skin ulcers (A)</p> Signup and view all the answers

What is recommended for males to address the late complication of fertility and teratogenicity after alkylating agent chemotherapy?

<p>Sperm or gamete cryopreservation (A)</p> Signup and view all the answers

Which late complication can result in a patient developing tumors years after chemotherapy or radiotherapy?

<p>Second Malignancies (C)</p> Signup and view all the answers

Which medication can lead to the late complication of acute myeloid leukemia among others?

<p>Melphalan (B)</p> Signup and view all the answers

Which chemotherapy agent is associated with the development of Raynaud's Syndrome as a late complication?

<p>Ifosfamide (D)</p> Signup and view all the answers

What late complication can occur after the use of temsirolimus?

<p>Metabolic Syndrome (A)</p> Signup and view all the answers

What is the usual timeframe for hair loss to begin after one chemotherapy treatment?

<p>7 to 10 days (D)</p> Signup and view all the answers

Which chemotherapeutic agent is NOT mentioned as a cause of alopecia?

<p>Paclitaxel (D)</p> Signup and view all the answers

What type of hypersensitivity reactions occur with all chemotherapy agents except nitrosureas and dactinomycin?

<p>Type 1 (C)</p> Signup and view all the answers

Which medication should be used for prevention of hypersensitivity reactions due to the release of cremophor?

<p>Diphenhydramine (B)</p> Signup and view all the answers

When should dexamethasone be administered to prevent hypersensitivity reactions with docetaxel therapy?

<p>1 day before therapy (B)</p> Signup and view all the answers

What is extravasation in the context of chemotherapy?

<p>Accidental administration of IV medications into surrounding tissues (A)</p> Signup and view all the answers

What is the purpose of applying warm compresses in extravasation treatment?

<p>To increase drug distribution and absorption (D)</p> Signup and view all the answers

Which drug is commonly associated with Hyperpigmentation as a dermatologic toxicity?

<p>Cytarabine (A)</p> Signup and view all the answers

What is the purpose of using Thiosulfate in chemotherapy?

<p>To neutralize extravasations (A)</p> Signup and view all the answers

Which chemotherapy agent is associated with Palmar-Plantar Erythrodysesthesia (Hand-foot syndrome)?

<p>5-FU (C)</p> Signup and view all the answers

What is the main consequence of giving chemotherapy concurrently with radiation therapy?

<p>Increased risk of redness and inflammation (B)</p> Signup and view all the answers

Which side effect is associated with exposure to UV light while on 5-FU chemotherapy?

<p>Photosensitivity reactions (B)</p> Signup and view all the answers

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