Dermatological Toxicities in Chemotherapy

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What is the main focus of extravasations management?

Administering drugs slowly

Applying cold compresses

Preventing extravasation (correct)

Treating local irritation and inflammation

Which of the following drugs can cause severe burning sensation and progress into necrosis if extravasated?

Etoposide

Oxaliplatin

Cisplatin

Paclitaxel (correct)

What should be verified by personnel after injecting 1-2 ml of drug to prevent extravasation?

Increase the drug dosage

Check for allergic reactions

Verify needle stability & blood flow return (correct)

Verify the drug expiration date

Which drug can be given as an IV infusion if extravasation occurs to reduce skin ulcers?

Dexrazoxane Signup and view all the answers

Which type of drugs cause local irritation, pain, and inflammation if extravasated?

Cisplatin Signup and view all the answers

What is the role of Dimethylsulfoxide (DMSO) in treating extravasation?

Act as a free radical scavenger to reduce skin ulcers Signup and view all the answers

What is recommended for males to address the late complication of fertility and teratogenicity after alkylating agent chemotherapy?

Sperm or gamete cryopreservation Signup and view all the answers

Which late complication can result in a patient developing tumors years after chemotherapy or radiotherapy?

Second Malignancies Signup and view all the answers

Which medication can lead to the late complication of acute myeloid leukemia among others?

Melphalan Signup and view all the answers

Which chemotherapy agent is associated with the development of Raynaud's Syndrome as a late complication?

Ifosfamide Signup and view all the answers

What late complication can occur after the use of temsirolimus?

Metabolic Syndrome Signup and view all the answers

What is the usual timeframe for hair loss to begin after one chemotherapy treatment?

7 to 10 days Signup and view all the answers

Which chemotherapeutic agent is NOT mentioned as a cause of alopecia?

Paclitaxel Signup and view all the answers

What type of hypersensitivity reactions occur with all chemotherapy agents except nitrosureas and dactinomycin?

Type 1 Signup and view all the answers

Which medication should be used for prevention of hypersensitivity reactions due to the release of cremophor?

Diphenhydramine Signup and view all the answers

When should dexamethasone be administered to prevent hypersensitivity reactions with docetaxel therapy?

1 day before therapy Signup and view all the answers

What is extravasation in the context of chemotherapy?

Accidental administration of IV medications into surrounding tissues Signup and view all the answers

What is the purpose of applying warm compresses in extravasation treatment?

To increase drug distribution and absorption Signup and view all the answers

Which drug is commonly associated with Hyperpigmentation as a dermatologic toxicity?

Cytarabine Signup and view all the answers

What is the purpose of using Thiosulfate in chemotherapy?

To neutralize extravasations Signup and view all the answers

Which chemotherapy agent is associated with Palmar-Plantar Erythrodysesthesia (Hand-foot syndrome)?

5-FU Signup and view all the answers

What is the main consequence of giving chemotherapy concurrently with radiation therapy?

Increased risk of redness and inflammation Signup and view all the answers

Which side effect is associated with exposure to UV light while on 5-FU chemotherapy?

Photosensitivity reactions Signup and view all the answers