Dental Pulp Stem Cells

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Questions and Answers

What is the minimum number of transcriptionally distinct states found in human dental pulp?

  • Five
  • Seven
  • Six (correct)
  • Eight

What genes are shown to be enriched in each cluster?

  • Top 500 genes
  • Top 10 genes
  • Top 198 genes (correct)
  • Top 50 genes

What is the name of the protein expressed in the growing apical papilla of human molar?

  • SFRP1 and SMOC1
  • SFRP4 and SMOC4
  • SFRP2 and SMOC2 (correct)
  • SFRP3 and SMOC3

What type of staining is used to differentiate Dental Stem Cells?

<p>Alizarin red staining (B)</p> Signup and view all the answers

What is the name of the journal where the research was published?

<p>Journal of Dental Research (A)</p> Signup and view all the answers

What type of tissue did the DPSCs generate in vivo?

<p>Dentin/pulp-like complexes (D)</p> Signup and view all the answers

What is the possible reason for DPSCs' broader capacity for differentiation?

<p>Their origin as neural crest derived cells (B)</p> Signup and view all the answers

What is the function of pericyte-derived cells during tooth growth and in response to damage?

<p>To differentiate into odontoblasts (B)</p> Signup and view all the answers

What was used to show the differentiation of pericytes into odontoblasts?

<p>Genetic lineage tracing (A)</p> Signup and view all the answers

What is the characteristic of MSCs in a single tissue according to the study?

<p>They have a dual origin (D)</p> Signup and view all the answers

What is suggested about the pericyte contribution to MSC-derived mesenchymal cells?

<p>It is variable and possibly dependent on the extent of vascularity (D)</p> Signup and view all the answers

What is the primary focus of the discussed strategies in dental tissue regeneration?

<p>Stimulating repair responses in dental tissues (C)</p> Signup and view all the answers

What is the response of pulp tissue in the early stage of injury?

<p>Up-regulation of the secretory activity of the odontoblasts (B)</p> Signup and view all the answers

What is the result of the odontoblasts' up-regulation in the early stage of injury?

<p>Focal deposition of reactionary dentin (A)</p> Signup and view all the answers

What is the primary goal of recruiting cells to become odontoblasts?

<p>To repair and replace damaged dental tissues (A)</p> Signup and view all the answers

What is the characteristic of the dentin formed by the existing primary odontoblasts?

<p>Regular tubular structure and tubular continuity (A)</p> Signup and view all the answers

What is the consequence of intense injury or disease progression in dental pulp?

<p>Local death of the odontoblasts and inflammatory process intensify (A)</p> Signup and view all the answers

What was observed after 2 weeks of implantation in SCID mouse kidney?

<p>Tooth like mineralized structures (C)</p> Signup and view all the answers

At what stage does human tooth development begin?

<p>Carnegie stage 19 (D)</p> Signup and view all the answers

What were HGEP cells grown on to form clusters?

<p>Low binding surface (D)</p> Signup and view all the answers

What was used for recombination with MM (E14.5)?

<p>Human adult gingival epithelial cells (D)</p> Signup and view all the answers

What was analyzed after 6 weeks of implantation?

<p>MicroCT scan (C)</p> Signup and view all the answers

What marks odontoblasts in the DSPP immuno-staining?

<p>Ob (C)</p> Signup and view all the answers

What is the primary role of Wnt signaling in the healing process?

<p>Controlling inflammation and programmed cell death (D)</p> Signup and view all the answers

What is the potential application of promoting Wnt/βCat signaling in tissue repair?

<p>Enhancing natural repair by overstimulating this pathway (B)</p> Signup and view all the answers

What is the purpose of hybrid scaffolds in periodontal cell and gene delivery?

<p>To deliver genes and cells to the wound site (B)</p> Signup and view all the answers

What is the main goal of organ engineering in the context of tooth repair?

<p>To create a bio-tooth (C)</p> Signup and view all the answers

What is the significance of whole tooth generation as a model?

<p>It allows for the study of tooth development (A)</p> Signup and view all the answers

What is the significance of the combination of epithelium and mesenchyme in tooth development?

<p>It enables the formation of a functional tooth (D)</p> Signup and view all the answers

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