Dental Pulp Stem Cells
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Questions and Answers

What is the minimum number of transcriptionally distinct states found in human dental pulp?

  • Five
  • Seven
  • Six (correct)
  • Eight
  • What genes are shown to be enriched in each cluster?

  • Top 500 genes
  • Top 10 genes
  • Top 198 genes (correct)
  • Top 50 genes
  • What is the name of the protein expressed in the growing apical papilla of human molar?

  • SFRP1 and SMOC1
  • SFRP4 and SMOC4
  • SFRP2 and SMOC2 (correct)
  • SFRP3 and SMOC3
  • What type of staining is used to differentiate Dental Stem Cells?

    <p>Alizarin red staining</p> Signup and view all the answers

    What is the name of the journal where the research was published?

    <p>Journal of Dental Research</p> Signup and view all the answers

    What type of tissue did the DPSCs generate in vivo?

    <p>Dentin/pulp-like complexes</p> Signup and view all the answers

    What is the possible reason for DPSCs' broader capacity for differentiation?

    <p>Their origin as neural crest derived cells</p> Signup and view all the answers

    What is the function of pericyte-derived cells during tooth growth and in response to damage?

    <p>To differentiate into odontoblasts</p> Signup and view all the answers

    What was used to show the differentiation of pericytes into odontoblasts?

    <p>Genetic lineage tracing</p> Signup and view all the answers

    What is the characteristic of MSCs in a single tissue according to the study?

    <p>They have a dual origin</p> Signup and view all the answers

    What is suggested about the pericyte contribution to MSC-derived mesenchymal cells?

    <p>It is variable and possibly dependent on the extent of vascularity</p> Signup and view all the answers

    What is the primary focus of the discussed strategies in dental tissue regeneration?

    <p>Stimulating repair responses in dental tissues</p> Signup and view all the answers

    What is the response of pulp tissue in the early stage of injury?

    <p>Up-regulation of the secretory activity of the odontoblasts</p> Signup and view all the answers

    What is the result of the odontoblasts' up-regulation in the early stage of injury?

    <p>Focal deposition of reactionary dentin</p> Signup and view all the answers

    What is the primary goal of recruiting cells to become odontoblasts?

    <p>To repair and replace damaged dental tissues</p> Signup and view all the answers

    What is the characteristic of the dentin formed by the existing primary odontoblasts?

    <p>Regular tubular structure and tubular continuity</p> Signup and view all the answers

    What is the consequence of intense injury or disease progression in dental pulp?

    <p>Local death of the odontoblasts and inflammatory process intensify</p> Signup and view all the answers

    What was observed after 2 weeks of implantation in SCID mouse kidney?

    <p>Tooth like mineralized structures</p> Signup and view all the answers

    At what stage does human tooth development begin?

    <p>Carnegie stage 19</p> Signup and view all the answers

    What were HGEP cells grown on to form clusters?

    <p>Low binding surface</p> Signup and view all the answers

    What was used for recombination with MM (E14.5)?

    <p>Human adult gingival epithelial cells</p> Signup and view all the answers

    What was analyzed after 6 weeks of implantation?

    <p>MicroCT scan</p> Signup and view all the answers

    What marks odontoblasts in the DSPP immuno-staining?

    <p>Ob</p> Signup and view all the answers

    What is the primary role of Wnt signaling in the healing process?

    <p>Controlling inflammation and programmed cell death</p> Signup and view all the answers

    What is the potential application of promoting Wnt/βCat signaling in tissue repair?

    <p>Enhancing natural repair by overstimulating this pathway</p> Signup and view all the answers

    What is the purpose of hybrid scaffolds in periodontal cell and gene delivery?

    <p>To deliver genes and cells to the wound site</p> Signup and view all the answers

    What is the main goal of organ engineering in the context of tooth repair?

    <p>To create a bio-tooth</p> Signup and view all the answers

    What is the significance of whole tooth generation as a model?

    <p>It allows for the study of tooth development</p> Signup and view all the answers

    What is the significance of the combination of epithelium and mesenchyme in tooth development?

    <p>It enables the formation of a functional tooth</p> Signup and view all the answers

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