Dental Pulp Stem Cells

What is the minimum number of transcriptionally distinct states found in human dental pulp?

Six

What genes are shown to be enriched in each cluster?

Top 198 genes

What is the name of the protein expressed in the growing apical papilla of human molar?

SFRP2 and SMOC2

What type of staining is used to differentiate Dental Stem Cells?

Alizarin red staining Signup and view all the answers

What is the name of the journal where the research was published?

Journal of Dental Research Signup and view all the answers

What type of tissue did the DPSCs generate in vivo?

Dentin/pulp-like complexes Signup and view all the answers

What is the possible reason for DPSCs' broader capacity for differentiation?

Their origin as neural crest derived cells Signup and view all the answers

What is the function of pericyte-derived cells during tooth growth and in response to damage?

To differentiate into odontoblasts Signup and view all the answers

What was used to show the differentiation of pericytes into odontoblasts?

Genetic lineage tracing Signup and view all the answers

What is the characteristic of MSCs in a single tissue according to the study?

They have a dual origin Signup and view all the answers

What is suggested about the pericyte contribution to MSC-derived mesenchymal cells?

It is variable and possibly dependent on the extent of vascularity Signup and view all the answers

What is the primary focus of the discussed strategies in dental tissue regeneration?

Stimulating repair responses in dental tissues Signup and view all the answers

What is the response of pulp tissue in the early stage of injury?

Up-regulation of the secretory activity of the odontoblasts Signup and view all the answers

What is the result of the odontoblasts' up-regulation in the early stage of injury?

Focal deposition of reactionary dentin Signup and view all the answers

What is the primary goal of recruiting cells to become odontoblasts?

To repair and replace damaged dental tissues Signup and view all the answers

What is the characteristic of the dentin formed by the existing primary odontoblasts?

Regular tubular structure and tubular continuity Signup and view all the answers

What is the consequence of intense injury or disease progression in dental pulp?

Local death of the odontoblasts and inflammatory process intensify Signup and view all the answers

What was observed after 2 weeks of implantation in SCID mouse kidney?

Tooth like mineralized structures Signup and view all the answers

At what stage does human tooth development begin?

Carnegie stage 19 Signup and view all the answers

What were HGEP cells grown on to form clusters?

Low binding surface Signup and view all the answers

What was used for recombination with MM (E14.5)?

Human adult gingival epithelial cells Signup and view all the answers

What was analyzed after 6 weeks of implantation?

MicroCT scan Signup and view all the answers

What marks odontoblasts in the DSPP immuno-staining?

Ob Signup and view all the answers

What is the primary role of Wnt signaling in the healing process?

Controlling inflammation and programmed cell death Signup and view all the answers

What is the potential application of promoting Wnt/βCat signaling in tissue repair?

Enhancing natural repair by overstimulating this pathway Signup and view all the answers

What is the purpose of hybrid scaffolds in periodontal cell and gene delivery?

To deliver genes and cells to the wound site Signup and view all the answers

What is the main goal of organ engineering in the context of tooth repair?

To create a bio-tooth Signup and view all the answers

What is the significance of whole tooth generation as a model?

It allows for the study of tooth development Signup and view all the answers

What is the significance of the combination of epithelium and mesenchyme in tooth development?

It enables the formation of a functional tooth Signup and view all the answers