Ch2pp35-37
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Questions and Answers

What is the main function of dendritic cells?

  • Initiating inflammation and stimulating adaptive immune responses (correct)
  • Killing bacteria with proteolytic enzymes
  • Producing histamine and vasoactive amines
  • Activating mast cells in the skin and mucosal tissues

    • Where are mast cells found?

  • Digestive system and respiratory system
  • Skin, mucosal tissues, and most connective tissues (correct)
  • Bone marrow and blood vessels
  • Lymph nodes and spleen

    • What activates mast cells as part of innate immunity?

  • Lymphocytes interacting with mast cells
  • Microbial products binding to TLRs (correct)
  • Proteolytic enzymes releasing histamine
  • Antibody-dependent mechanism

    • What do mast cell granules contain?

    <p>Vasoactive amines, proteolytic enzymes, lipid mediators, and cytokines</p> Signup and view all the answers

    What is the role of mast cell products?

    <p>Defense against helminths and other pathogens, protection against snake and insect venoms, and responsible for allergic disease symptoms</p> Signup and view all the answers

    What is the origin of tissue-resident macrophages in fetal life?

    <p>Yolk sac and liver</p> Signup and view all the answers

    What do Innate Lymphoid Cells (ILCs) produce?

    <p>Cytokines similar to those secreted by helper T lymphocytes</p> Signup and view all the answers

    What stimulates the responses of ILCs?

    <p>Cytokines produced by damaged epithelial and other cells at sites of infection</p> Signup and view all the answers

    How are macrophages activated in innate immune responses?

    <p>Microbial products binding to TLRs and cytokines like interferon-γ (IFN-γ)</p> Signup and view all the answers

    What promotes the phagocytosis of complement-coated microbes by macrophages?

    <p>Cell surface complement receptors</p> Signup and view all the answers

    Where are ILCs always present?

    <p>Tissues</p> Signup and view all the answers

    What is the contribution of ILCs to host defense or immunologic diseases?

    <p>Unclear, especially in humans</p> Signup and view all the answers

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