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Questions and Answers
What is the primary factor determining the primary structure of a protein?
What is the primary factor determining the primary structure of a protein?
Which level of protein structure is stabilized by hydrogen bonds between backbone atoms, resulting in structures like alpha-helices and beta-pleated sheets?
Which level of protein structure is stabilized by hydrogen bonds between backbone atoms, resulting in structures like alpha-helices and beta-pleated sheets?
What type of interaction is NOT a main force that holds the tertiary structure of a protein together?
What type of interaction is NOT a main force that holds the tertiary structure of a protein together?
Which of the following best describes the quaternary structure of a protein?
Which of the following best describes the quaternary structure of a protein?
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What is the most likely consequence of protein denaturation?
What is the most likely consequence of protein denaturation?
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Which type of protein is NOT fixed to one spot in the body and is involved in transport or signaling?
Which type of protein is NOT fixed to one spot in the body and is involved in transport or signaling?
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What is the primary function of serum albumins in blood plasma?
What is the primary function of serum albumins in blood plasma?
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Unlike blood plasma proteins, where is hemoglobin primarily located?
Unlike blood plasma proteins, where is hemoglobin primarily located?
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How does insulin affect glucose uptake by cells?
How does insulin affect glucose uptake by cells?
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What is the function of somatropin in the human body?
What is the function of somatropin in the human body?
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Which structural feature is characteristic of collagen?
Which structural feature is characteristic of collagen?
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Where is elastin particularly important in the human body?
Where is elastin particularly important in the human body?
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What is a key characteristic of proteoglycans?
What is a key characteristic of proteoglycans?
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What is the main function of fibronectin?
What is the main function of fibronectin?
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What percentage of total dietary intake should proteins comprise?
What percentage of total dietary intake should proteins comprise?
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Which of the following is the most accurate description of homeostasis in living organisms?
Which of the following is the most accurate description of homeostasis in living organisms?
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Which statement best explains the relationship between catabolism and anabolism?
Which statement best explains the relationship between catabolism and anabolism?
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Why is carbon considered the basis of life on Earth?
Why is carbon considered the basis of life on Earth?
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How does the first law of thermodynamics apply to living organisms?
How does the first law of thermodynamics apply to living organisms?
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What role does ATP play in living organisms?
What role does ATP play in living organisms?
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What distinguishes a micronutrient from a macronutrient?
What distinguishes a micronutrient from a macronutrient?
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How does RNA differ structurally from DNA?
How does RNA differ structurally from DNA?
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Which type of hydrocarbon contains at least one carbon-carbon double bond?
Which type of hydrocarbon contains at least one carbon-carbon double bond?
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An atom has 6 electrons in its outermost shell. How many more electrons does it need to fill this shell and what type of bonds is it most likely to form?
An atom has 6 electrons in its outermost shell. How many more electrons does it need to fill this shell and what type of bonds is it most likely to form?
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Which of the following best describes the relative strength of intermolecular bonds compared to intramolecular bonds?
Which of the following best describes the relative strength of intermolecular bonds compared to intramolecular bonds?
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How does electronegativity influence the formation of polar covalent bonds?
How does electronegativity influence the formation of polar covalent bonds?
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Why do hydrophobic molecules tend to cluster together in an aqueous solution?
Why do hydrophobic molecules tend to cluster together in an aqueous solution?
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How does an acid affect the pH of water?
How does an acid affect the pH of water?
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What distinguishes spatial isomers from structural isomers?
What distinguishes spatial isomers from structural isomers?
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In the context of thermodynamics, what does a negative $\Delta$G (Gibbs free energy) indicate about a reaction?
In the context of thermodynamics, what does a negative $\Delta$G (Gibbs free energy) indicate about a reaction?
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Flashcards
Organization
Organization
Being composed of one or more cells, vital units of life.
Metabolism
Metabolism
The chemical processes necessary for maintaining life, including catabolism and anabolism.
Homeostasis
Homeostasis
Regulation of the internal environment to maintain stability, like temperature control.
Response to Stimuli
Response to Stimuli
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ATP
ATP
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Macronutrients
Macronutrients
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Micronutrients
Micronutrients
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Covalent Bonds
Covalent Bonds
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Ionic Bonds
Ionic Bonds
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Hydrogen Bonds
Hydrogen Bonds
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Entropy
Entropy
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Gibbs Free Energy
Gibbs Free Energy
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Exergonic Reactions
Exergonic Reactions
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Endergonic Reactions
Endergonic Reactions
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Nutrients
Nutrients
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Basal Metabolic Rate (BMR)
Basal Metabolic Rate (BMR)
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Thermic Effect of Food (TEF)
Thermic Effect of Food (TEF)
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Essential Amino Acids
Essential Amino Acids
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Dipeptide
Dipeptide
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Polypeptide
Polypeptide
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Quaternary Structure
Quaternary Structure
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Denaturation
Denaturation
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Dynamic Proteins
Dynamic Proteins
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Static Proteins
Static Proteins
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Hemoglobin
Hemoglobin
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Myoglobin
Myoglobin
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Insulin
Insulin
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Collagen
Collagen
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Actin
Actin
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Proteoglycans
Proteoglycans
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Study Notes
Conventional Definitions of Life
- Organization: Composed of one or more cells, the basic units of life.
- Reproduction: Ability to produce new organisms.
- Metabolism: Chemical processes necessary for life maintenance.
- Catabolism: Breaking down substances to release energy.
- Anabolism: Synthesizing substances using energy.
- Growth: Increased complexity from simpler to more complex forms.
- Homeostasis: Maintaining a constant internal environment.
- Examples: Sweating to reduce temperature, shivering to increase temperature.
- Response to Stimuli: Ability to react to a stimulus.
- Adaptation: Ability to respond over time to environmental changes.
Other Proposed Features of Life
- Carbon Containing: Carbon forms the foundation of life on Earth.
- Reliance on Water: Water is essential for all life forms.
- Genetic Information: Uses DNA and RNA to store the blueprint for an organism.
What is a Molecule?
- Molecule: Smallest particle of a substance retaining its properties.
- Atom: Smallest particle of an element retaining its chemical properties; a molecule may be composed of one or more atoms
Molecular Characteristics of Life
- Thermodynamics: Life obeys the laws of thermodynamics.
- ATP: Common energy currency of life.
- Biological Molecules: Structure depends on similar biological molecules (e.g., proteins, lipids, carbohydrates, nucleic acids).
What is a Nutrient?
- Nutrient: Substance with nutritional value for an organism.
- Micronutrients: Required in small amounts (vitamins, microminerals).
- Macronutrients: Required in large amounts (carbohydrates, proteins, lipids).
Vitamins
- Act as cofactors for enzymes, and are organic compounds loosely bound to the enzyme during chemical reactions.
Nucleic Acids
- Essential for maintaining, growing, and repairing DNA and RNA.
- RNA is a messenger that carries instructions from DNA.
- RNA uses uracil instead of thymine.
- RNA is single-stranded.
Hydrocarbon Nomenclature
- Hydrocarbons: Chemical compounds containing only hydrogen and carbon.
- Alkane: Carbon-carbon single bonds.
- Alkene: At least one carbon-carbon double bond.
- Alkyne: At least one carbon-carbon triple bond.
Methods of Drawing Hydrocarbons
- Structural: Straight lines represent bonds.
- Condensed: Combines hydrogen atoms with carbons for simpler representation.
- Skeletal: Intersections represent carbon atoms.
Naming Linear Hydrocarbons
- Use prefixes to name hydrocarbons according to the number of carbon atoms present.
Atomic Structure
- Atoms have a central nucleus with protons and neutrons, with electrons orbiting around the nucleus.
- The number of protons defines the element.
Bond Formation by Atoms
- Atoms form bonds to fill their outermost electron shell.
- Number of bonds formed depends on the number of electrons needed to fill or empty the outermost partially filled orbital
Number of Bonds Formed by Bioelements
List of elements and the number of bonds formed by each.
Chemical Bonds
- Types of Chemical Bonds -Intramolecular(covalent and ionic bonds) within a molecule. -Intermolecular (hydrogen bonds, Van der Waals forces, hydrophilic interactions) between molecules.
Relative Chemical Bond Strengths
- Intramolecular bonds require more energy to form but also release more energy when broken compared to intermolecular ones.
Covalent Bonds
- Sharing of electrons between atoms resulting in stable bonds.
Ionic Bonds
- Transfer of electrons between atoms resulting in oppositely charged ions that attract each other.
Hydrogen Bonds
- Attraction between hydrogen and another highly electronegative atom.
Van der Waals Forces
- Temporary electrostatic attraction between molecules.
Electronegativity and Polarity
- Electronegativity is the ability of an atom to attract electrons.
- Polarity arises from unequal sharing of electrons.
- Bond polarity is determined by the difference in electronegativity.
Polar Bonds vs Polar Molecules
- A polar bond is within a molecule.
- Polar molecules involve multiple polar bonds and the overall shape of the molecule.
Water Properties
- Water is a polar molecule.
- Oxygen has a partial negative charge, and hydrogen atoms have partial positive charges.
Importance of Polarity in Solubility
- Polar substances dissolve in polar solvents, and nonpolar substances dissolve in nonpolar solvents.
Acids and Bases
- Acids are proton donors.
- Bases are proton acceptors.
Isomers
- Isomers have the same molecular formula but different atomic arrangements.
Structural Isomers
- Different bonding arrangements between atoms.
Spatial Isomers
- Same bonding arrangement, but different spatial positioning of atoms.
Energy in Biochemistry
- Energy is transferred between molecules in chemical reactions.
- Change in enthalpy measures the heat change in reactions (delta H).
- Exergonic reactions release energy (delta H negative).
- Endergonic reactions require energy input (delta H positive).
Negative delta H - Exothermic
Loss of heat, energy released, Final product temp less than initial reactant temp
Positive delta H - Endothermic
Gain of heat , energy absorbed, Final product temp more than initial reactant temp
Negative Delta G - Spontaneous Reaction
- The reaction will proceed spontaneously.
Spontaneous Reactions:
Reactions occur naturally without external influence
What else determines if a reaction is possible?
Entropy and second law of thermodynamics factors.
Entropy
- Measure of disorder or randomness in a system.
- Higher entropy means more disorder.
- Reactions tend toward higher entropy.
Gibbs Free Energy
- Combines enthalpy and entropy changes.
Exergonic vs Endergonic Reactions
Exergonic reactions release energy; Endergonic reactions require energy.
Conditions Favouring Exergonic Reactions
- Reactions that lose heat and gain entropy are energetically favorable
DeltaG vs DeltaG°
- delta G is the actual free energy change under specific conditions.
- DeltaG° is under standard conditions (298k, 1atm, 1M concentration)
Energy in Food - Gross Energy
- Gross energy is the total energy in food.
- Energy is released by combustion or oxidation.
Useable Energy
Energy for organismic functions such as growth, maintenance, and reproduction
Energy Out
Expenditures over 24hrs, including Basal Metabolic Rate (BMR) and Thermic Effect of Food (TEF), and activity level.
3 factors affecting Obesity Epidemics
Intake of fast food, added sugar, and large portion sizes.
Amino Acids
Building blocks of protein, with 20 standard amino acids, some essential in the diet.
Protein Peptides
- Amino acids linked by peptide bonds into chains, from dipeptides to oligopeptides (short chains) to larger polypeptides that constitute proteins.
Protein Polymers
Polypeptides that are larger (more than 50 aa)
Biological Proteins
Proteins (hundreds to thousands of amino acids) function in various biological roles, in different, complex structures
Protein Structure Levels
Levels of protein structure include primary, secondary, tertiary, and quaternary structures
Structure of Proteins (Detail)
Describes polypeptide sequence order, interactions amongst amino acids for secondary structures (alpha helices, beta sheets), 3D folding for tertiary structures, and interactions of multiple polypeptide subunits in quaternary structures. Includes different forces holding structures together (hydrogen bonds, disulfide bonds etc)
Dynamic vs Static Proteins
- Dynamic proteins are not fixed in one spot in the body. Ex: transporter proteins, enzymes
- Static proteins are fixed to one location in the body. Ex: collagen, actin/myosin
Serum Albumins
- Water-soluble proteins (60% of plasma proteins).
- Maintain osmotic pressure.
Globulins
- Water-soluble proteins (40% of plasma proteins).
- Transport, binding, and eliminating foreign particles
Hemoglobin
- Protein in red blood cells.
- Transports oxygen.
Myoglobin
- Protein in muscle cells.
- Stores oxygen.
Insulin
- Hormone controlling blood glucose levels.
Thyroid Hormones (T3 and T4).
- Produced in thyroid gland.
- Regulate metabolism and growth.
Somatotropin
- Growth hormone produced in the pituitary gland.
- Stimulates growth and development
Collagen
- Structural protein in connective tissues.
- Abundant in mammals.
Elastin
- Flexible protein in connective tissues (skin, ligaments, blood vessels.
Proteoglycans
- Proteins with carbohydrate chains.
- Important components of connective tissues.
Fibronectin
Extracellular matrix protein.
Actin and Myosin
Proteins involved in muscle contraction
Dietary Protein
- Dietary protein intake: 10-35%.
- Essential AA synthesis by body: 10-12.
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Description
Explore the conventional definitions that characterize life, including organization, reproduction, metabolism, and homeostasis. Understand the role of carbon, water, and genetic information in living organisms, along with a brief introduction to molecules. Test your knowledge on the essential features that constitute life.