Podcast
Play an AI-generated podcast conversation about this lesson
Questions and Answers
What is the primary mechanism by which dantrolene reduces muscle contraction?
What is the primary mechanism by which dantrolene reduces muscle contraction?
- By increasing the release of calcium from the sarcoplasmic reticulum
- By stimulating the release of GABA from the spinal cord
- By activating the release of acetylcholine from the motor neuron
- By inhibiting the ryanodine receptor (correct)
Which of the following is a contraindication for the use of dantrolene?
Which of the following is a contraindication for the use of dantrolene?
- Active hepatic disease (correct)
- Diabetes mellitus
- Pregnancy and lactation (category B)
- Hypertension
What is the primary indication for the use of intravenous dantrolene?
What is the primary indication for the use of intravenous dantrolene?
- Neuroleptic malignant syndrome
- Muscle spasms
- Spasticity
- Malignant hyperthermia (correct)
Which of the following is a potential side effect of dantrolene?
Which of the following is a potential side effect of dantrolene?
Signup and view all the answers
What is the primary concern when using dantrolene in patients with impaired renal function?
What is the primary concern when using dantrolene in patients with impaired renal function?
Signup and view all the answers
What is the category of dantrolene in pregnancy and lactation?
What is the category of dantrolene in pregnancy and lactation?
Signup and view all the answers
Which of the following medications may interact with dantrolene?
Which of the following medications may interact with dantrolene?
Signup and view all the answers
Flashcards are hidden until you start studying
Study Notes
Dantrolene
What is Dantrolene?
- A medication used to treat malignant hyperthermia, a life-threatening medical emergency
- Also used to treat muscle spasms, spasticity, and other muscle disorders
Mechanism of Action
- Works by reducing the release of calcium from the sarcoplasmic reticulum, which leads to muscle relaxation
- Inhibits the ryanodine receptor, a key player in muscle contraction
Indications
- Malignant hyperthermia
- Muscle spasms
- Spasticity
- Neuroleptic malignant syndrome
- Heat stroke
Administration
- Available in oral and intravenous forms
- Oral form used for chronic treatment of muscle spasms and spasticity
- IV form used for malignant hyperthermia and other acute conditions
Side Effects
- Drowsiness
- Dizziness
- Diarrhea
- Fatigue
- Muscle weakness
Contraindications
- Active hepatic disease
- Impaired pulmonary function
- Cardiac disease
- Pregnancy and lactation (category C)
Special Considerations
- Can cause hepatotoxicity, monitor liver function regularly
- May interact with other medications, such as MAOIs and SSRIs
- Use with caution in patients with impaired renal function
Dantrolene
- A medication used to treat malignant hyperthermia and muscle disorders
Mechanism of Action
- Reduces release of calcium from sarcoplasmic reticulum, leading to muscle relaxation
- Inhibits ryanodine receptor, a key player in muscle contraction
Indications
- Malignant hyperthermia
- Muscle spasms
- Spasticity
- Neuroleptic malignant syndrome
- Heat stroke
Administration
- Available in oral and intravenous forms
- Oral form used for chronic treatment of muscle spasms and spasticity
- IV form used for malignant hyperthermia and other acute conditions
Side Effects
- Drowsiness
- Dizziness
- Diarrhea
- Fatigue
- Muscle weakness
Contraindications
- Active hepatic disease
- Impaired pulmonary function
- Cardiac disease
- Pregnancy and lactation (category C)
Special Considerations
- Can cause hepatotoxicity, monitor liver function regularly
- May interact with MAOIs and SSRIs
- Use with caution in patients with impaired renal function
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
