7 Questions
What is the primary mechanism by which dantrolene reduces muscle contraction?
By inhibiting the ryanodine receptor
Which of the following is a contraindication for the use of dantrolene?
Active hepatic disease
What is the primary indication for the use of intravenous dantrolene?
Malignant hyperthermia
Which of the following is a potential side effect of dantrolene?
Drowsiness
What is the primary concern when using dantrolene in patients with impaired renal function?
Risk of accumulation and toxicity
What is the category of dantrolene in pregnancy and lactation?
Category C
Which of the following medications may interact with dantrolene?
MAOIs and SSRIs
Study Notes
Dantrolene
What is Dantrolene?
- A medication used to treat malignant hyperthermia, a life-threatening medical emergency
- Also used to treat muscle spasms, spasticity, and other muscle disorders
Mechanism of Action
- Works by reducing the release of calcium from the sarcoplasmic reticulum, which leads to muscle relaxation
- Inhibits the ryanodine receptor, a key player in muscle contraction
Indications
- Malignant hyperthermia
- Muscle spasms
- Spasticity
- Neuroleptic malignant syndrome
- Heat stroke
Administration
- Available in oral and intravenous forms
- Oral form used for chronic treatment of muscle spasms and spasticity
- IV form used for malignant hyperthermia and other acute conditions
Side Effects
- Drowsiness
- Dizziness
- Diarrhea
- Fatigue
- Muscle weakness
Contraindications
- Active hepatic disease
- Impaired pulmonary function
- Cardiac disease
- Pregnancy and lactation (category C)
Special Considerations
- Can cause hepatotoxicity, monitor liver function regularly
- May interact with other medications, such as MAOIs and SSRIs
- Use with caution in patients with impaired renal function
Dantrolene
- A medication used to treat malignant hyperthermia and muscle disorders
Mechanism of Action
- Reduces release of calcium from sarcoplasmic reticulum, leading to muscle relaxation
- Inhibits ryanodine receptor, a key player in muscle contraction
Indications
- Malignant hyperthermia
- Muscle spasms
- Spasticity
- Neuroleptic malignant syndrome
- Heat stroke
Administration
- Available in oral and intravenous forms
- Oral form used for chronic treatment of muscle spasms and spasticity
- IV form used for malignant hyperthermia and other acute conditions
Side Effects
- Drowsiness
- Dizziness
- Diarrhea
- Fatigue
- Muscle weakness
Contraindications
- Active hepatic disease
- Impaired pulmonary function
- Cardiac disease
- Pregnancy and lactation (category C)
Special Considerations
- Can cause hepatotoxicity, monitor liver function regularly
- May interact with MAOIs and SSRIs
- Use with caution in patients with impaired renal function
Learn about Dantrolene, a medication used to treat malignant hyperthermia, muscle spasms, and other muscle disorders. Understand its mechanism of action and indications.
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