Questions and Answers
What is the class of Danazol?
What is the mechanism of Danazol?
Suppresses the pituitary-ovarian axis and reduces FSH and LH production, leading to reduced estrogen levels and a temporary menopause.
Which of the following are indications for Danazol? (Select all that apply)
What is one contraindication for using Danazol?
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A side effect of Danazol is _____ .
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Which of the following medications interact with Danazol? (Select all that apply)
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What is the method of elimination for Danazol?
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What is the usual dose of Danazol for endometriosis?
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Study Notes
Danazol Overview
- An antiprogestogen used to manage various conditions related to hormonal imbalance.
Mechanism of Action
- Suppresses the pituitary-ovarian axis.
- Reduces production of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH).
- Leads to decreased estrogen levels and induces a temporary menopause-like state.
Indications for Use
- Effective treatment for endometriosis, managing symptoms and slowing disease progression.
- Utilized in fibrocystic breast disease to alleviate discomfort.
- Treats hereditary angioedema, preventing attacks and symptoms.
Contraindications
- Not suitable for pregnant individuals due to potential harm to the fetus.
- Contraindicated in patients with a history of venous thromboembolism (VTE).
- Avoid use in cases of undiagnosed genital bleeding or androgen-dependent tumors.
- Acute porphyria patients should not take danazol due to exacerbation risks.
Side Effects
- Significant side effects may include substantial weight gain.
- Skin issues like acne may arise.
- Psychological effects such as mood changes can occur.
- Development of masculine features, including increased hair growth and deepening of voice.
Drug Interactions
- Caution with antidiabetics, as danazol may affect glucose control.
- Interaction noted with carbamazepine and ciclosporin, necessitating adjustments in dosing.
- Statins may have altered effects; monitoring required.
- Tacrolimus and vitamin D analogues can also interact.
- Warfarin's efficacy may change; careful monitoring of coagulation levels is needed.
Elimination
- Excreted through both renal and fecal routes, indicating metabolism and elimination processes.
Usual Dosage
- For endometriosis treatment, the typical dosage is 100-200 mg orally twice daily for a maximum duration of 6 months.
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Description
Explore the role of Danazol in treating hormonal imbalances, including conditions like endometriosis and fibrocystic breast disease. This quiz covers its mechanism of action, indications, contraindications, and potential side effects. Test your knowledge on the therapeutic applications and safety considerations of this antiprogestogen.
