15 Questions
What is the primary role of Cytotoxic T Cells?
Recognizing and attacking virally infected cells and tumor cells
Where do Cytotoxic T Cells mature before being released into the blood?
Thymus
What do Cytotoxic T Cells bind with on the surface of their own nucleated cells, except for macrophages?
Major Histocompatibility Complex-I (MHC-I)
Which type of co-receptor do Cytotoxic T Cells develop along with their T Cell Receptor (TCR) during maturation?
CD8
What type of chemical signals are required for the activation of Cytotoxic T Cells?
From dendritic and T helper cells
What do Cytotoxic T Cells release to cause lysis of the infected target cell?
Perforin proteins and granzyme
What type of immune cells do Cytotoxic T Cells belong to?
Lymphocyte
Which co-receptor do Cytotoxic T Cells develop during their maturation process?
CD8
Where are Cytotoxic T Cells produced?
Thymus
What do Cytotoxic T Cells release when encountering virally infected cells?
Tumor Necrosis Factor - alpha (TF-a)
What do Cytotoxic T Cells bind with on the surface of their own nucleated cells, except for macrophages?
Major Histocompatibility Complex-I (MHC-I)
Which of these chemical signals are required for the activation of Cytotoxic T Cells?
Interferon-gamma (IFN-y)
What is the primary role of Cytotoxic T Cells?
Recognize virally infected cells and tumor cells
Which proteins do Cytotoxic T Cells release to cause lysis of the infected target cell?
Perforin and Granzyme
Where do Cytotoxic T Cells mature before being released into the blood?
Thymus
Study Notes
Cytotoxic T Cells
- Primary role: to recognize and eliminate infected cells or tumor cells by inducing apoptosis (programmed cell death)
- Maturation: thymus, before being released into the blood
- Self-binding: bind with MHC I (Major Histocompatibility Complex I) on the surface of their own nucleated cells, except for macrophages
- Co-receptor development: CD8 (Cluster of Differentiation 8) along with their T Cell Receptor (TCR) during maturation
- Activation signals: require IL-2 (Interleukin 2) and other cytokines for activation
- Lysis mechanism: release cytotoxins, such as perforin and granzymes, to cause lysis of the infected target cell
- Immune cell classification: belong to the T cell type of immune cells
- Co-receptor development: CD8 during maturation process
- Production site: thymus
- Response to viral infection: release cytotoxins when encountering virally infected cells
- Self-binding: bind with MHC I on the surface of their own nucleated cells, except for macrophages
- Activation signals: require IL-2 and other cytokines for activation
- Primary role: to recognize and eliminate infected cells or tumor cells by inducing apoptosis
- Lysis mechanism: release perforin and granzymes to cause lysis of the infected target cell
Test your knowledge about Cytotoxic T Cells, a group of immune cells that recognize virally infected cells and tumor cells. Learn about their development, maturation process, and functions in the immune system.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
