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Questions and Answers
What is the primary role of Cytotoxic T Cells?
What is the primary role of Cytotoxic T Cells?
- Aiding in blood clotting processes
- Recognizing and attacking virally infected cells and tumor cells (correct)
- Regulating inflammation in the body
- Producing antibodies to neutralize pathogens
Where do Cytotoxic T Cells mature before being released into the blood?
Where do Cytotoxic T Cells mature before being released into the blood?
- Spleen
- Bone marrow
- Lymph nodes
- Thymus (correct)
What do Cytotoxic T Cells bind with on the surface of their own nucleated cells, except for macrophages?
What do Cytotoxic T Cells bind with on the surface of their own nucleated cells, except for macrophages?
- Major Histocompatibility Complex-II (MHC-II)
- Major Histocompatibility Complex-I (MHC-I) (correct)
- Interferon-gamma (IFN-y)
- Tumor Necrosis Factor - alpha (TF-a)
Which type of co-receptor do Cytotoxic T Cells develop along with their T Cell Receptor (TCR) during maturation?
Which type of co-receptor do Cytotoxic T Cells develop along with their T Cell Receptor (TCR) during maturation?
What type of chemical signals are required for the activation of Cytotoxic T Cells?
What type of chemical signals are required for the activation of Cytotoxic T Cells?
What do Cytotoxic T Cells release to cause lysis of the infected target cell?
What do Cytotoxic T Cells release to cause lysis of the infected target cell?
What type of immune cells do Cytotoxic T Cells belong to?
What type of immune cells do Cytotoxic T Cells belong to?
Which co-receptor do Cytotoxic T Cells develop during their maturation process?
Which co-receptor do Cytotoxic T Cells develop during their maturation process?
Where are Cytotoxic T Cells produced?
Where are Cytotoxic T Cells produced?
What do Cytotoxic T Cells release when encountering virally infected cells?
What do Cytotoxic T Cells release when encountering virally infected cells?
What do Cytotoxic T Cells bind with on the surface of their own nucleated cells, except for macrophages?
What do Cytotoxic T Cells bind with on the surface of their own nucleated cells, except for macrophages?
Which of these chemical signals are required for the activation of Cytotoxic T Cells?
Which of these chemical signals are required for the activation of Cytotoxic T Cells?
What is the primary role of Cytotoxic T Cells?
What is the primary role of Cytotoxic T Cells?
Which proteins do Cytotoxic T Cells release to cause lysis of the infected target cell?
Which proteins do Cytotoxic T Cells release to cause lysis of the infected target cell?
Where do Cytotoxic T Cells mature before being released into the blood?
Where do Cytotoxic T Cells mature before being released into the blood?
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Study Notes
Cytotoxic T Cells
- Primary role: to recognize and eliminate infected cells or tumor cells by inducing apoptosis (programmed cell death)
- Maturation: thymus, before being released into the blood
- Self-binding: bind with MHC I (Major Histocompatibility Complex I) on the surface of their own nucleated cells, except for macrophages
- Co-receptor development: CD8 (Cluster of Differentiation 8) along with their T Cell Receptor (TCR) during maturation
- Activation signals: require IL-2 (Interleukin 2) and other cytokines for activation
- Lysis mechanism: release cytotoxins, such as perforin and granzymes, to cause lysis of the infected target cell
- Immune cell classification: belong to the T cell type of immune cells
- Co-receptor development: CD8 during maturation process
- Production site: thymus
- Response to viral infection: release cytotoxins when encountering virally infected cells
- Self-binding: bind with MHC I on the surface of their own nucleated cells, except for macrophages
- Activation signals: require IL-2 and other cytokines for activation
- Primary role: to recognize and eliminate infected cells or tumor cells by inducing apoptosis
- Lysis mechanism: release perforin and granzymes to cause lysis of the infected target cell
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