18 Questions
What is the size of microtubules (MT) in diameter?
24 nm
Which end of a microtubule (MT) exhibits faster assembly and disassembly?
The (+) end
What is the composition of tubulin subunits in microtubules?
Heterodimers of α and β tubulin monomers
Which agent binds to tubulin and stabilizes microtubules (MTs)?
Taxol
What is the main role of MAP1, MAP2, and Tau in relation to microtubules?
Crosslink microtubules to intermediate filaments
Which structure is primarily composed of stable, long-lived microtubules?
Cilia and flagella
What is the function of actin filaments in cellular motility?
Supporting stress fibers
How does treadmilling occur in actin filaments?
Subunits are released at the (-) end and reassemble at the (+) end
What is the function of thymosin β4 in relation to actin assembly?
Inhibition of actin assembly
Which protein is involved in the regulation of actin polymerization, length, and stability?
Gelsolin
Which agent leads to depolymerization of actin filaments?
Cytochalasin D
What is the size range of actin filaments in diameter?
7-9 nm
Which protein is responsible for (-) end-directed movement along microtubules?
Dynein
What is the primary function of microtubules in intracellular transport?
Function as tracks for vesicles, proteins, and organelles
Which disease is characterized by the hyperphosphorylation of tau protein?
Alzheimer's disease
What is the role of dynein arms in cilia and flagella bending?
Produce a bending force by sliding between microtubule pairs
What structure is responsible for the movement of cilia and flagella?
Radial spokes and central pair MTs
Which protein complex links dynein to vesicles and microtubules?
Dynactin complex
Explore the composition and dynamics of microtubules in the cytoskeleton, including their size, heterodimer structure of α and β tubulin monomers, GTP binding, and involvement in cell shape, motility, and various cellular functions.
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