Cytoskeleton: Microtubules Composition and Dynamics
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Questions and Answers

What is the size of microtubules (MT) in diameter?

  • 36 nm
  • 48 nm
  • 12 nm
  • 24 nm (correct)
  • Which end of a microtubule (MT) exhibits faster assembly and disassembly?

  • The (-) end
  • The middle section
  • Both ends show the same speed
  • The (+) end (correct)
  • What is the composition of tubulin subunits in microtubules?

  • Polymers of single tubulin type
  • Heterotrimers of α, β, and γ tubulin monomers
  • Heterodimers of α and β tubulin monomers (correct)
  • Homodimers of α tubulin monomers
  • Which agent binds to tubulin and stabilizes microtubules (MTs)?

    <p>Taxol</p> Signup and view all the answers

    What is the main role of MAP1, MAP2, and Tau in relation to microtubules?

    <p>Crosslink microtubules to intermediate filaments</p> Signup and view all the answers

    Which structure is primarily composed of stable, long-lived microtubules?

    <p>Cilia and flagella</p> Signup and view all the answers

    What is the function of actin filaments in cellular motility?

    <p>Supporting stress fibers</p> Signup and view all the answers

    How does treadmilling occur in actin filaments?

    <p>Subunits are released at the (-) end and reassemble at the (+) end</p> Signup and view all the answers

    What is the function of thymosin β4 in relation to actin assembly?

    <p>Inhibition of actin assembly</p> Signup and view all the answers

    Which protein is involved in the regulation of actin polymerization, length, and stability?

    <p>Gelsolin</p> Signup and view all the answers

    Which agent leads to depolymerization of actin filaments?

    <p>Cytochalasin D</p> Signup and view all the answers

    What is the size range of actin filaments in diameter?

    <p>7-9 nm</p> Signup and view all the answers

    Which protein is responsible for (-) end-directed movement along microtubules?

    <p>Dynein</p> Signup and view all the answers

    What is the primary function of microtubules in intracellular transport?

    <p>Function as tracks for vesicles, proteins, and organelles</p> Signup and view all the answers

    Which disease is characterized by the hyperphosphorylation of tau protein?

    <p>Alzheimer's disease</p> Signup and view all the answers

    What is the role of dynein arms in cilia and flagella bending?

    <p>Produce a bending force by sliding between microtubule pairs</p> Signup and view all the answers

    What structure is responsible for the movement of cilia and flagella?

    <p>Radial spokes and central pair MTs</p> Signup and view all the answers

    Which protein complex links dynein to vesicles and microtubules?

    <p><strong>Dynactin complex</strong></p> Signup and view all the answers

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