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Cytoskeleton: Microtubules Composition and Dynamics

18 Questions

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Cytoskeleton: Microtubules Composition and Dynamics

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Questions and Answers

What is the size of microtubules (MT) in diameter?

36 nm

48 nm

12 nm

24 nm (correct)

Which end of a microtubule (MT) exhibits faster assembly and disassembly?

The (-) end

The middle section

Both ends show the same speed

The (+) end (correct)

What is the composition of tubulin subunits in microtubules?

Polymers of single tubulin type

Heterotrimers of α, β, and γ tubulin monomers

Heterodimers of α and β tubulin monomers (correct)

Homodimers of α tubulin monomers

Which agent binds to tubulin and stabilizes microtubules (MTs)?

Taxol Signup and view all the answers

What is the main role of MAP1, MAP2, and Tau in relation to microtubules?

Crosslink microtubules to intermediate filaments Signup and view all the answers

Which structure is primarily composed of stable, long-lived microtubules?

Cilia and flagella Signup and view all the answers

What is the function of actin filaments in cellular motility?

Supporting stress fibers Signup and view all the answers

How does treadmilling occur in actin filaments?

Subunits are released at the (-) end and reassemble at the (+) end Signup and view all the answers

What is the function of thymosin β4 in relation to actin assembly?

Inhibition of actin assembly Signup and view all the answers

Which protein is involved in the regulation of actin polymerization, length, and stability?

Gelsolin Signup and view all the answers

Which agent leads to depolymerization of actin filaments?

Cytochalasin D Signup and view all the answers

What is the size range of actin filaments in diameter?

7-9 nm Signup and view all the answers

Which protein is responsible for (-) end-directed movement along microtubules?

Dynein Signup and view all the answers

What is the primary function of microtubules in intracellular transport?

Function as tracks for vesicles, proteins, and organelles Signup and view all the answers

Which disease is characterized by the hyperphosphorylation of tau protein?

Alzheimer's disease Signup and view all the answers

What is the role of dynein arms in cilia and flagella bending?

Produce a bending force by sliding between microtubule pairs Signup and view all the answers

What structure is responsible for the movement of cilia and flagella?

Radial spokes and central pair MTs Signup and view all the answers

Which protein complex links dynein to vesicles and microtubules?

Dynactin complex Signup and view all the answers