WK 1: Cytoskeleton and Cell Movement

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What is the fundamental basis for cell movement and intracellular transport?

Intermediate filaments

Microfilaments

Microtubules

Cytoskeleton (correct)

Which of the following diseases is NOT a result of mutations or 'poisoning' of the cytoskeleton?

Diabetes (correct)

Neurodegeneration

Myopathies

Cancer

What is the significance of the actin cytoskeleton in skeletal muscle function?

It enables cellular motion

It provides support and maintains cell shape

It is the basis of skeletal muscle function (correct)

It protects the cell

Which of the following drugs is a significant target of the cytoskeleton?

Vincristine Signup and view all the answers

What is the diameter of microtubules?

25 nm Signup and view all the answers

What is the primary function of microtubules in the context of cell movement?

Powering the beating motion of cilia and flagella Signup and view all the answers

Which of the following diseases is NOT a result of a mutation or poisoning of the cytoskeleton?

Gout Signup and view all the answers

Which drug targets microtubules and is used to treat ovarian cancer?

Taxol Signup and view all the answers

What is the name of the protein that forms a stabilizing protein for microtubules and is involved in neurodegeneration?

Tau Signup and view all the answers

What is the name of the syndrome that is a result of a mutation in the cilia and flagella?

Kartagener Syndrome Signup and view all the answers

What is the primary function of myosin II in cell crawling?

Contracting and pulling the cell in the direction of actin filaments Signup and view all the answers

What is a negative consequence of microfilament dysregulation in cancer?

Metastasis Signup and view all the answers

What is a characteristic of intermediate filaments?

Extension from the perinucleus to the cell periphery Signup and view all the answers

Which of the following is an example of a disease resulting from intermediate filament dysfunction?

Skin disorders Signup and view all the answers

Which of the following drugs is a significant target for microtubule dysregulation?

All of the above Signup and view all the answers

What is the direction of movement of dynein motor proteins along microtubules?

Towards the negative pole (-) Signup and view all the answers

What is the role of Microtubule Associated Proteins (MAPs) in microtubules?

To stabilize microtubules through protein interactions Signup and view all the answers

What is the characteristic of microtubules in terms of their dynamic instability?

They undergo alternating periods of polymerization and depolymerization Signup and view all the answers

What is the main function of kinesin motor proteins in microtubules?

To move vesicles away from the cell body Signup and view all the answers

What is the internal diameter of microtubules?

14 nm Signup and view all the answers

What is the primary function of capping proteins in microfilaments?

To prevent further polymerisation Signup and view all the answers

What is the energy source used by myosin to move along microfilaments?

ATP hydrolysis Signup and view all the answers

What is the result of actin-ATP polymerisation?

Formation of F-actin Signup and view all the answers

What is the function of gelsolin in microfilaments?

To sever microfilaments Signup and view all the answers

What is a key function of microfilaments in cells?

Maintenance of cell shape Signup and view all the answers