10 Questions
Which cell type does CMV establish latency in?
Hematopoietic progenitor cells
What is one mechanism by which CMV prevents antigen presentation to T cells?
Inhibiting MHC I molecule expression
In which body fluids can CMV be shed?
Breast milk
What is a common symptom of CMV mononucleosis?
Splenomegaly
How is CMV transmitted in patients attending sexually transmitted disease clinics?
Sexually transmitted
What is the mechanism by which CMV prevents antigen presentation to natural killer (NK) cells?
Preventing expression of MHC I molecules
In CMV mononucleosis, why is heterophile antibody not present, unlike in EBV infection?
CMV infects and activates B cells
What is a characteristic feature of CMV infection in transplant recipients during periods of intense immunosuppression?
Pulmonary infection with interstitial mononuclear infiltrate
How does CMV establish latency in the body?
In hematopoietic progenitor cells in bone marrow
Which organ is primarily affected in CMV infection in solid-organ transplant recipients?
Lung
Test your knowledge on the characteristics of Cytomegalovirus (CMV) including its membership in the Betaherpesvirinae subfamily, ability to carry specific mRNAs into host cells, latency in monocytes, and permissive cells for replication.
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