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Questions and Answers
Which of the following cytokines is produced by macrophages and stimulates the production of C-Reactive Protein?
Which of the following cytokines is produced by macrophages and stimulates the production of C-Reactive Protein?
- IL-1
- TNF (correct)
- IL-8
- IL-6
What is the role of C-Reactive Protein in the body?
What is the role of C-Reactive Protein in the body?
- To bind to phosphocholine receptor on bacteria and assist in complement binding to the cell surface (correct)
- To stimulate the production of IL-6 by macrophages
- To inhibit elastase produced by granules in neutrophil
- To attract immune cells to the site of infection
Which of the following acute phase proteins has a 50,000-fold increase in response to increased production of IL-6 by macrophages?
Which of the following acute phase proteins has a 50,000-fold increase in response to increased production of IL-6 by macrophages?
- C-Reactive Protein (correct)
- Serum Amyloid A
- Alpha-1 antitrypsin
- Tumour Necrosis Factor
What is the primary function of alpha-1 antitrypsin?
What is the primary function of alpha-1 antitrypsin?
Which of the following is NOT a cytokine that stimulates the acute phase response?
Which of the following is NOT a cytokine that stimulates the acute phase response?
Which cell type produces Serum Amyloid A in response to infection?
Which cell type produces Serum Amyloid A in response to infection?
What is the primary function of acute phase proteins during inflammation?
What is the primary function of acute phase proteins during inflammation?
Which cells are responsible for the production of acute phase proteins in the body?
Which cells are responsible for the production of acute phase proteins in the body?
What is the main role of the acute phase response in the body's defence mechanism?
What is the main role of the acute phase response in the body's defence mechanism?
Which type of proteins are involved in activating the complement cascade and stimulating chemotaxis of phagocytes during inflammation?
Which type of proteins are involved in activating the complement cascade and stimulating chemotaxis of phagocytes during inflammation?
What is the significance of measuring acute phase proteins in a laboratory setting?
What is the significance of measuring acute phase proteins in a laboratory setting?
Which molecules are primarily responsible for mediating the acute phase response and changes in acute phase protein concentrations?
Which molecules are primarily responsible for mediating the acute phase response and changes in acute phase protein concentrations?
What is the main role of ceruloplasmin in inhibiting bacterial uptake of iron?
What is the main role of ceruloplasmin in inhibiting bacterial uptake of iron?
Which protein, when at low levels, is believed to inhibit bacterial growth due to reduced molecular transport?
Which protein, when at low levels, is believed to inhibit bacterial growth due to reduced molecular transport?
What is the function of Haptoglobin in restricting bacterial utilization of iron?
What is the function of Haptoglobin in restricting bacterial utilization of iron?
In the context of the acute phase response, what biomarker would be preferred for short-term (<24 hours) monitoring of inflammation?
In the context of the acute phase response, what biomarker would be preferred for short-term (<24 hours) monitoring of inflammation?
Why has Plasma Viscosity (PV) been used as a replacement for Erythrocyte Sedimentation Rate (ESR) in some laboratories?
Why has Plasma Viscosity (PV) been used as a replacement for Erythrocyte Sedimentation Rate (ESR) in some laboratories?
What is the significance of high ESR values (>100 mm/hr) in terms of predicting disease?
What is the significance of high ESR values (>100 mm/hr) in terms of predicting disease?
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