CYP1A1 and CYP1A2 Isoforms Quiz

Which human CYP1A subfamily member is primarily responsible for the activation of the carcinogen aflatoxin B1?

What is the function of the CYP1A subfamily in the metabolism of environmental carcinogens?

Where is CYP1A1 primarily expressed?

Which compound is NOT metabolized by CYP1A2?

What is another name for CYP1A1?

Which CYP2 isoform represents only approximately 4% of total hepatic P450 isoforms?

Which cytochrome P450 isoform is expressed primarily in extrahepatic tissues such as kidney, adrenal, brain, uterus, breast, ovary, and intestine?

Which cytochrome P450 isoform metabolizes approximately 15% of clinically relevant drugs and is involved in metabolizing endogenous compounds such as steroids, melatonin, retinoids, and arachidonic acid?

Which cytochrome P450 isoform is responsible for at least 30 different drug oxidations, representing approximately 21% of clinically important drugs?

Which cytochrome P450 isoform is expressed highest in nasal epithelium followed by lung and trachea with high interindividual variability?

Which cytochrome P450 isoform represents less than 1% of the total hepatic P450 isoforms and has a low level of expression in the liver?

Which cytochrome P450 isoform metabolizes arachidonic acid, lauric acid, 17beta-estradiol, estrone, ethinyl estradiol, and testosterone among others?